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Opinion Review
Copyright: ©Author(s) 2026.
World J Psychiatry. Sep 19, 2026; 16(9): 115802
Published online Sep 19, 2026. doi: 10.5498/wjp.115802
Table 1 Synthesis of mental health outcomes among college students during coronavirus disease 2019 lockdowns (expanded)
Ref.
Country/region
Sample size
Key findings (prevalence/predictors)
Notable ER/coping factors examined
Zhao et al[4]China494Depression: 65.0%; anxiety: 69.4%; stress: 50.8%Compensatory spending (β = 0.13-0.19), binge eating (β = 0.14-0.19), recreational activities (β = -0.25 to -0.30) as key ER habits
Cao et al[2]China7143Anxiety: 24.9% (mild: 21.3%; moderate: 2.7%; severe: 0.9%)Family instability and economic concerns as major stressors
Liu et al[11]United States898Depression: 43.5%; anxiety: 45.4%COVID-19 exposure, financial stress, weak social support
Browning et al[13]United States1621Significant increases in depression/anxiety from pre-pandemic baselineLoneliness was the strongest predictor; coping through substance use was a risk factor
Li et al[14]China746217Approximately 35% experienced psychological distressPoor sleep quality and family relationships were major correlates
Pfefferbaum and North[15]ReviewN/ASummarized acute and chronic stress responses in youthHighlighted disruption of routines and uncertainty as key mediators
Aristovnik et al[16]62 countries31212 studentsHigh levels of anxiety (37.5%) and depression (33.6%)Academic stress, isolation, and concerns about academic future were top stressors
Table 2 Risk and protective factors for student mental health during lockdowns: A thematic synthesis
Factor category
Specific factors
Association with mental health
Proposed mechanism/ER framework
Ref.
Maladaptive ER/risk factorsCompensatory spendingPositive (β approximately 0.13-0.19)[1]Experiential avoidance; mood repair; financial stress feedback loopZhang and Ma[7]; Rajkumar[8]
Binge eating/emotional eatingPositive (β approximately 0.14-0.19)[1]Emotional dysregulation; avoidance; physiological guilt/shame cyclesCoakley et al[19]; Rodríguez-Rey et al[28]
Problematic internet/social media usePositiveAvoidance, social comparison, sleep disruptionMarciano et al[20]; Boursier et al[21]
RuminationStrong positivePerseverative cognitive focus on distress; amplifies negative affectCao et al[2]
Adaptive ER/protective factorsRecreational activities/hobbiesNegative (β approximately -0.25 to -0.30)[1]Behavioral activation; attentional deployment; flow/mastery experiencesQuan et al[18]; Heumann et al[35]
Physical activity/exerciseNegative (βapproximately -0.22)Behavioral activation; physiological stress buffering (e.g., endorphins)Stanton et al[10]
Mindfulness/acceptanceNegativeReduced experiential avoidance; decentering from negative thoughtsHong et al[26]; Conversano et al[27]
Cognitive reappraisalNegativeReinterpreting stressors; finding meaning; promoting psychological flexibilityGross[5]
Social support (virtual/in-person)Negative (β approximately -0.19)Social sharing; co-regulation; belongingnessYe et al[9]; Ooi et al[17]
Contextual and demographic moderatorsLower socioeconomic statusPositiveIncreased material hardship, less access to resources, higher baseline stressQuan et al[18]; Amerio et al[56]
High academic stressStrong positiveThreat to self-efficacy and future prospects; performance pressureSteare et al[38]; Sundarasen et al[54]
Poor sleep qualityStrong positiveBidirectional relationship; impairs prefrontal cortex function needed for ERCellini et al[55]; Alvaro et al[59]
Loneliness/lack of social integrationStrong positiveUnmet need for connection; lack of co-regulation opportunitiesBu et al[51]; Killgore et al[52]
Table 3 Theoretical frameworks for understanding emotion regulation and mental health during crisis
Theoretical framework
Core tenet
Application to pandemic findings
Ref.
Process model of emotion regulation (Gross)ER unfolds over time via situation selection, modification, attentional deployment, cognitive change, and response modulationLockdowns limited situation selection/modification, increasing burden on cognitive change (reappraisal) which many found difficult, leading to maladaptive response modulation (e.g., binge eating)Gross[5]
Transdiagnostic/RDoC approachShared underlying mechanisms (like ER deficits) cut across traditional diagnostic categoriesExplains high comorbidity (r approximately 0.85-0.96) of depression, anxiety, and stress; points to interventions targeting shared processes (e.g., intolerance of uncertainty)Woon et al[33]; Keshavan et al[34]
Allostatic load/chronic stress modelChronic stress leads to wear-and-tear on physiological systems (neuroendocrine, immune), impairing brain function and mental healthLockdowns were a chronic stressor; allostatic load links pandemic stress to long-term mental and physical health risksMcEwen[31]; Guidi et al[32]
Behavioral models (e.g., BA for depression)Depression is maintained by a cycle of avoidance, reduced activity, and loss of positive reinforcementLoss of campus activities and routines depleted positive reinforcement; protective factors like recreational activities worked via behavioral activationHeumann et al[35]
Social baseline theoryThe human brain expects proximity to social resources; distancing taxes our neural and metabolic resources for regulationSocial isolation forced individuals to “go it alone” neurologically, depleting resources for ER and increasing distressCoan and Sbarra[36]; Eisenberger[37]
Table 4 Proposed intervention framework based on review evidence
Intervention level
Target
Example strategies
Theoretical basis
Universal prevention (all students)Promote adaptive ER, reduce stigmaCurriculum-integrated psychoeducation on stress management and ER skills[5,26]. Campus-wide wellness campaigns promoting physical activity[10], sleep[55,59], hobbies[18]. Training faculty in psychological first aid and referral pathwaysMental health literacy; positive psychology; behavioral activation models[35]
Selected prevention (at-risk groups)Address specific risk factorsWorkshops for students with financial stress (financial literacy, budgeting)[7,8,18]. Skills groups for emotional eating[23,24] or problematic internet use[20,21]. Support groups for international students, low-income students[18,51]Cognitive-behavioral therapy; dialectical behavior therapy skills
Indicated intervention/treatment (symptomatic students)Treat clinical symptomsIncreased access to telehealth cognitive-behavioral therapy, acceptance and commitment therapy, or unified protocol[34]. Prescription and guidance for use of evidence-based mental health apps. Collaboration with campus health services for medication management if neededTransdiagnostic cognitive-behavioral therapy[33,34]; pharmacotherapy
Environmental/policyModify structural determinantsFlexible academic policies (deadline extensions, pass/fail options)[16,38,54]. Emergency funds and grants for students in financial need[18,56]. Ensuring affordable, reliable internet and suitable study spaces. Creating and subsidizing opportunities for safe social/recreational engagement[4,9,17,18]Socioecological model; public health approach


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