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Retrospective Study
©Author(s) (or their employer(s)) 2026.
World J Psychiatry. Mar 19, 2026; 16(3): 114348
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114348
Table 1 Basic demographic characteristics of thyroid cancer patients, n (%)
Characteristic
Total (n = 180)
Male (n = 48)
Female (n = 132)
χ²/t value
P value
Age group2.1840.336
Young group (18-44 years)66 (36.7)15 (31.3)51 (38.6)
Middle-aged group (45-59 years)77 (42.8)22 (45.8)55 (41.7)
Elderly group (≥ 60 years)37 (20.6)11 (22.9)26 (19.7)
Marital status1.7560.416
Married148 (82.2)41 (85.4)107 (81.1)
Unmarried24 (13.3)5 (10.4)19 (14.4)
Divorced/widowed8 (4.4)2 (4.2)6 (4.5)
Education level4.8920.180
High school and below69 (38.3)21 (43.8)48 (36.4)
College diploma61 (33.9)14 (29.2)47 (35.6)
Bachelor's degree and above50 (27.8)13 (27.1)37 (28.0)
Occupation6.1240.147
Mental workers86 (47.8)19 (39.6)67 (50.8)
Manual workers53 (29.4)18 (37.5)35 (26.5)
Retired/unemployed41 (22.8)11 (22.9)30 (22.7)
Residence0.1420.706
Urban65 (36.1)18 (37.5)47 (35.6)
Rural115 (63.9)30 (62.5)85 (64.4)
Table 2 Disease-related characteristics of thyroid cancer patients, n (%)
Characteristic
Total (n = 180)
Male (n = 48)
Female (n = 132)
χ² value
P value
Pathological type2.0450.563
Papillary carcinoma161 (89.4)41 (85.4)120 (90.9)
Follicular carcinoma13 (7.2)5 (10.4)8 (6.1)
Medullary carcinoma4 (2.2)1 (2.1)3 (2.3)
Others2 (1.1)1 (2.1)1 (0.8)
TNM staging3.8920.273
Stage I87 (48.3)20 (41.7)67 (50.8)
Stage II55 (30.6)15 (31.3)40 (30.3)
Stage III27 (15.0)10 (20.8)17 (12.9)
Stage IV11 (6.1)3 (6.3)8 (6.1)
Tumor size1.7820.410
≤ 1 cm46 (25.6)10 (20.8)36 (27.3)
1.1-2 cm69 (38.3)18 (37.5)51 (38.6)
> 2 cm65 (36.1)20 (41.7)45 (34.1)
Lymph node metastasis0.2980.585
Yes86 (47.8)24 (50.0)62 (47.0)
No94 (52.2)24 (50.0)70 (53.0)
Treatment modality3.0840.214
Surgery138 (76.7)34 (70.8)104 (78.8)
Surgery + iodine-131 therapy34 (18.9)12 (25.0)22 (16.7)
Comprehensive treatment8 (4.4)2 (4.2)6 (4.5)
Comorbidities
Hypertension42 (23.3)13 (27.1)29 (22.0)0.5420.462
Diabetes17 (9.4)6 (12.5)11 (8.3)0.6950.404
Cardiovascular disease21 (11.7)8 (16.7)13 (9.8)1.5840.208
Family history of malignancy30 (16.7)9 (18.8)21 (15.9)0.2150.643
Previous surgical history45 (25.0)13 (27.1)32 (24.2)0.1650.685
Table 3 Comparison of psychological health status between male and female thyroid cancer patients, mean ± SD
Assessment index
Male (n = 48)
Female (n = 132)
t value
P value
Effect size (Cohen's d)
Self-Rating Anxiety Scale anxiety score
Total score42.6 ± 8.447.5 ± 9.3-3.1420.0020.56
Cognitive dimension9.1 ± 2.310.9 ± 2.6-4.012< 0.0010.74
Affective dimension8.0 ± 2.09.4 ± 2.4-3.2840.0010.63
Somatic dimension10.4 ± 2.711.5 ± 3.0-2.0890.0380.38
Behavioral dimension4.9 ± 1.55.9 ± 1.8-3.1470.0020.61
Self-Rating Depression Scale depression score
Total score45.0 ± 8.949.8 ± 10.1-2.8540.0050.51
Affective symptoms10.7 ± 2.812.5 ± 3.1-3.2850.0010.61
Cognitive symptoms8.8 ± 2.110.2 ± 2.5-3.1840.0020.60
Somatic symptoms11.2 ± 2.912.2 ± 3.3-1.7420.0830.32
Psychomotor symptoms5.1 ± 1.65.0 ± 1.70.3240.7460.06
World Health Organization Quality of Life Scale Brief Version Quality of Life
Overall quality of life3.5 ± 0.73.1 ± 0.82.8460.0050.53
Overall health status3.3 ± 0.82.9 ± 0.82.6820.0080.50
Physical health domain68.2 ± 12.164.5 ± 13.41.6240.1060.29
Psychological health domain69.8 ± 11.563.7 ± 12.62.7560.0060.51
Social relationships domain66.1 ± 12.963.4 ± 14.31.0870.2780.20
Environment domain65.3 ± 11.863.1 ± 13.10.9740.3310.18
Table 4 Comparison of psychological health status among different age groups of thyroid cancer patients, mean ± SD
Assessment index
Young group (n = 66)
Middle-aged group (n = 77)
Elderly group (n = 37)
F value
P value
Self-Rating Anxiety Scale anxiety score
Total score49.4 ± 9.6145.2 ± 8.5241.1 ± 7.7312.847< 0.001
Cognitive dimension11.5 ± 2.7110.3 ± 2.428.8 ± 2.0313.524< 0.001
Affective dimension9.9 ± 2.519.0 ± 2.227.5 ± 1.8312.185< 0.001
Somatic dimension12.2 ± 3.1110.9 ± 2.829.3 ± 2.3310.963< 0.001
Behavioral dimension6.0 ± 1.915.3 ± 1.624.3 ± 1.339.847< 0.001
Self-Rating Depression Scale depression score
Total score52.1 ± 10.4147.4 ± 9.2242.9 ± 8.5311.652< 0.001
Affective symptoms13.4 ± 3.3111.6 ± 2.929.7 ± 2.5316.284< 0.001
Cognitive symptoms10.7 ± 2.619.5 ± 2.328.1 ± 1.9313.147< 0.001
Somatic symptoms12.9 ± 3.4111.7 ± 3.1210.0 ± 2.739.284< 0.001
Psychomotor symptoms5.1 ± 1.84.6 ± 1.54.9 ± 1.61.4850.229
World Health Organization Quality of Life Scale Brief Version Quality of Life
Overall quality of life2.8 ± 0.733.3 ± 0.823.7 ± 0.6110.847< 0.001
Overall health status2.6 ± 0.733.1 ± 0.823.5 ± 0.7110.285< 0.001
Physical health domain61.2 ± 13.5366.1 ± 12.6271.8 ± 11.2110.147< 0.001
Psychological health domain60.5 ± 12.4365.6 ± 12.1271.4 ± 11.5111.285< 0.001
Social relationships domain59.8 ± 14.5365.1 ± 13.2269.3 ± 12.016.7420.002
Environment domain59.5 ± 12.9363.7 ± 12.5268.4 ± 11.617.1840.001
Table 5 Comparison of anxiety and depression detection rates by gender and age groups, n (%)
Grouping
Anxiety detection
χ² value
P value
Depression detection
χ² value
P value
Gender6.8470.0097.5240.006
Male (n = 48)14 (29.2)12 (25.0)
Female (n = 132)60 (45.5)57 (43.2)
Age groups14.28510.00112.84710.002
Young group (n = 66)36 (54.5)33 (50.0)
Middle-aged group (n = 77)28 (36.4)26 (33.8)
Elderly group (n = 37)10 (27.0)10 (27.0)
Table 6 Multiple linear regression analysis of Self-Rating Anxiety Scale anxiety score influencing factors
Variable
Regression coefficient β
SE
Standardized coefficient β'
t value
P value
95%CI
Gender (female)3.7421.2850.2082.9120.0041.208-6.276
Age group (young group)4.1861.2470.2353.3560.0011.728-6.644
TNM staging (stages III and IV)3.0521.4120.1522.1620.0320.267-5.837
Education level (high school and below)2.7631.1640.1662.3740.0190.470-5.056