©Author(s) (or their employer(s)) 2026.
World J Psychiatry. Mar 19, 2026; 16(3): 114348
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114348
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114348
Table 1 Basic demographic characteristics of thyroid cancer patients, n (%)
| Characteristic | Total (n = 180) | Male (n = 48) | Female (n = 132) | χ²/t value | P value |
| Age group | 2.184 | 0.336 | |||
| Young group (18-44 years) | 66 (36.7) | 15 (31.3) | 51 (38.6) | ||
| Middle-aged group (45-59 years) | 77 (42.8) | 22 (45.8) | 55 (41.7) | ||
| Elderly group (≥ 60 years) | 37 (20.6) | 11 (22.9) | 26 (19.7) | ||
| Marital status | 1.756 | 0.416 | |||
| Married | 148 (82.2) | 41 (85.4) | 107 (81.1) | ||
| Unmarried | 24 (13.3) | 5 (10.4) | 19 (14.4) | ||
| Divorced/widowed | 8 (4.4) | 2 (4.2) | 6 (4.5) | ||
| Education level | 4.892 | 0.180 | |||
| High school and below | 69 (38.3) | 21 (43.8) | 48 (36.4) | ||
| College diploma | 61 (33.9) | 14 (29.2) | 47 (35.6) | ||
| Bachelor's degree and above | 50 (27.8) | 13 (27.1) | 37 (28.0) | ||
| Occupation | 6.124 | 0.147 | |||
| Mental workers | 86 (47.8) | 19 (39.6) | 67 (50.8) | ||
| Manual workers | 53 (29.4) | 18 (37.5) | 35 (26.5) | ||
| Retired/unemployed | 41 (22.8) | 11 (22.9) | 30 (22.7) | ||
| Residence | 0.142 | 0.706 | |||
| Urban | 65 (36.1) | 18 (37.5) | 47 (35.6) | ||
| Rural | 115 (63.9) | 30 (62.5) | 85 (64.4) |
Table 2 Disease-related characteristics of thyroid cancer patients, n (%)
| Characteristic | Total (n = 180) | Male (n = 48) | Female (n = 132) | χ² value | P value |
| Pathological type | 2.045 | 0.563 | |||
| Papillary carcinoma | 161 (89.4) | 41 (85.4) | 120 (90.9) | ||
| Follicular carcinoma | 13 (7.2) | 5 (10.4) | 8 (6.1) | ||
| Medullary carcinoma | 4 (2.2) | 1 (2.1) | 3 (2.3) | ||
| Others | 2 (1.1) | 1 (2.1) | 1 (0.8) | ||
| TNM staging | 3.892 | 0.273 | |||
| Stage I | 87 (48.3) | 20 (41.7) | 67 (50.8) | ||
| Stage II | 55 (30.6) | 15 (31.3) | 40 (30.3) | ||
| Stage III | 27 (15.0) | 10 (20.8) | 17 (12.9) | ||
| Stage IV | 11 (6.1) | 3 (6.3) | 8 (6.1) | ||
| Tumor size | 1.782 | 0.410 | |||
| ≤ 1 cm | 46 (25.6) | 10 (20.8) | 36 (27.3) | ||
| 1.1-2 cm | 69 (38.3) | 18 (37.5) | 51 (38.6) | ||
| > 2 cm | 65 (36.1) | 20 (41.7) | 45 (34.1) | ||
| Lymph node metastasis | 0.298 | 0.585 | |||
| Yes | 86 (47.8) | 24 (50.0) | 62 (47.0) | ||
| No | 94 (52.2) | 24 (50.0) | 70 (53.0) | ||
| Treatment modality | 3.084 | 0.214 | |||
| Surgery | 138 (76.7) | 34 (70.8) | 104 (78.8) | ||
| Surgery + iodine-131 therapy | 34 (18.9) | 12 (25.0) | 22 (16.7) | ||
| Comprehensive treatment | 8 (4.4) | 2 (4.2) | 6 (4.5) | ||
| Comorbidities | |||||
| Hypertension | 42 (23.3) | 13 (27.1) | 29 (22.0) | 0.542 | 0.462 |
| Diabetes | 17 (9.4) | 6 (12.5) | 11 (8.3) | 0.695 | 0.404 |
| Cardiovascular disease | 21 (11.7) | 8 (16.7) | 13 (9.8) | 1.584 | 0.208 |
| Family history of malignancy | 30 (16.7) | 9 (18.8) | 21 (15.9) | 0.215 | 0.643 |
| Previous surgical history | 45 (25.0) | 13 (27.1) | 32 (24.2) | 0.165 | 0.685 |
Table 3 Comparison of psychological health status between male and female thyroid cancer patients, mean ± SD
| Assessment index | Male (n = 48) | Female (n = 132) | t value | P value | Effect size (Cohen's d) |
| Self-Rating Anxiety Scale anxiety score | |||||
| Total score | 42.6 ± 8.4 | 47.5 ± 9.3 | -3.142 | 0.002 | 0.56 |
| Cognitive dimension | 9.1 ± 2.3 | 10.9 ± 2.6 | -4.012 | < 0.001 | 0.74 |
| Affective dimension | 8.0 ± 2.0 | 9.4 ± 2.4 | -3.284 | 0.001 | 0.63 |
| Somatic dimension | 10.4 ± 2.7 | 11.5 ± 3.0 | -2.089 | 0.038 | 0.38 |
| Behavioral dimension | 4.9 ± 1.5 | 5.9 ± 1.8 | -3.147 | 0.002 | 0.61 |
| Self-Rating Depression Scale depression score | |||||
| Total score | 45.0 ± 8.9 | 49.8 ± 10.1 | -2.854 | 0.005 | 0.51 |
| Affective symptoms | 10.7 ± 2.8 | 12.5 ± 3.1 | -3.285 | 0.001 | 0.61 |
| Cognitive symptoms | 8.8 ± 2.1 | 10.2 ± 2.5 | -3.184 | 0.002 | 0.60 |
| Somatic symptoms | 11.2 ± 2.9 | 12.2 ± 3.3 | -1.742 | 0.083 | 0.32 |
| Psychomotor symptoms | 5.1 ± 1.6 | 5.0 ± 1.7 | 0.324 | 0.746 | 0.06 |
| World Health Organization Quality of Life Scale Brief Version Quality of Life | |||||
| Overall quality of life | 3.5 ± 0.7 | 3.1 ± 0.8 | 2.846 | 0.005 | 0.53 |
| Overall health status | 3.3 ± 0.8 | 2.9 ± 0.8 | 2.682 | 0.008 | 0.50 |
| Physical health domain | 68.2 ± 12.1 | 64.5 ± 13.4 | 1.624 | 0.106 | 0.29 |
| Psychological health domain | 69.8 ± 11.5 | 63.7 ± 12.6 | 2.756 | 0.006 | 0.51 |
| Social relationships domain | 66.1 ± 12.9 | 63.4 ± 14.3 | 1.087 | 0.278 | 0.20 |
| Environment domain | 65.3 ± 11.8 | 63.1 ± 13.1 | 0.974 | 0.331 | 0.18 |
Table 4 Comparison of psychological health status among different age groups of thyroid cancer patients, mean ± SD
| Assessment index | Young group (n = 66) | Middle-aged group (n = 77) | Elderly group (n = 37) | F value | P value |
| Self-Rating Anxiety Scale anxiety score | |||||
| Total score | 49.4 ± 9.61 | 45.2 ± 8.52 | 41.1 ± 7.73 | 12.847 | < 0.001 |
| Cognitive dimension | 11.5 ± 2.71 | 10.3 ± 2.42 | 8.8 ± 2.03 | 13.524 | < 0.001 |
| Affective dimension | 9.9 ± 2.51 | 9.0 ± 2.22 | 7.5 ± 1.83 | 12.185 | < 0.001 |
| Somatic dimension | 12.2 ± 3.11 | 10.9 ± 2.82 | 9.3 ± 2.33 | 10.963 | < 0.001 |
| Behavioral dimension | 6.0 ± 1.91 | 5.3 ± 1.62 | 4.3 ± 1.33 | 9.847 | < 0.001 |
| Self-Rating Depression Scale depression score | |||||
| Total score | 52.1 ± 10.41 | 47.4 ± 9.22 | 42.9 ± 8.53 | 11.652 | < 0.001 |
| Affective symptoms | 13.4 ± 3.31 | 11.6 ± 2.92 | 9.7 ± 2.53 | 16.284 | < 0.001 |
| Cognitive symptoms | 10.7 ± 2.61 | 9.5 ± 2.32 | 8.1 ± 1.93 | 13.147 | < 0.001 |
| Somatic symptoms | 12.9 ± 3.41 | 11.7 ± 3.12 | 10.0 ± 2.73 | 9.284 | < 0.001 |
| Psychomotor symptoms | 5.1 ± 1.8 | 4.6 ± 1.5 | 4.9 ± 1.6 | 1.485 | 0.229 |
| World Health Organization Quality of Life Scale Brief Version Quality of Life | |||||
| Overall quality of life | 2.8 ± 0.73 | 3.3 ± 0.82 | 3.7 ± 0.61 | 10.847 | < 0.001 |
| Overall health status | 2.6 ± 0.73 | 3.1 ± 0.82 | 3.5 ± 0.71 | 10.285 | < 0.001 |
| Physical health domain | 61.2 ± 13.53 | 66.1 ± 12.62 | 71.8 ± 11.21 | 10.147 | < 0.001 |
| Psychological health domain | 60.5 ± 12.43 | 65.6 ± 12.12 | 71.4 ± 11.51 | 11.285 | < 0.001 |
| Social relationships domain | 59.8 ± 14.53 | 65.1 ± 13.22 | 69.3 ± 12.01 | 6.742 | 0.002 |
| Environment domain | 59.5 ± 12.93 | 63.7 ± 12.52 | 68.4 ± 11.61 | 7.184 | 0.001 |
Table 5 Comparison of anxiety and depression detection rates by gender and age groups, n (%)
| Grouping | Anxiety detection | χ² value | P value | Depression detection | χ² value | P value |
| Gender | 6.847 | 0.009 | 7.524 | 0.006 | ||
| Male (n = 48) | 14 (29.2) | 12 (25.0) | ||||
| Female (n = 132) | 60 (45.5) | 57 (43.2) | ||||
| Age groups | 14.2851 | 0.001 | 12.8471 | 0.002 | ||
| Young group (n = 66) | 36 (54.5) | 33 (50.0) | ||||
| Middle-aged group (n = 77) | 28 (36.4) | 26 (33.8) | ||||
| Elderly group (n = 37) | 10 (27.0) | 10 (27.0) |
Table 6 Multiple linear regression analysis of Self-Rating Anxiety Scale anxiety score influencing factors
| Variable | Regression coefficient β | SE | Standardized coefficient β' | t value | P value | 95%CI |
| Gender (female) | 3.742 | 1.285 | 0.208 | 2.912 | 0.004 | 1.208-6.276 |
| Age group (young group) | 4.186 | 1.247 | 0.235 | 3.356 | 0.001 | 1.728-6.644 |
| TNM staging (stages III and IV) | 3.052 | 1.412 | 0.152 | 2.162 | 0.032 | 0.267-5.837 |
| Education level (high school and below) | 2.763 | 1.164 | 0.166 | 2.374 | 0.019 | 0.470-5.056 |
- Citation: Li W, Su YX, Wang C, Wang YL, Gao SX, Bao J, Zhu QW. Age-related and sex-related disparities in psychological distress among thyroid cancer patients: A retrospective study. World J Psychiatry 2026; 16(3): 114348
- URL: https://www.wjgnet.com/2220-3206/full/v16/i3/114348.htm
- DOI: https://dx.doi.org/10.5498/wjp.v16.i3.114348
