Clinical efficacy and effects on hypothalamic-pituitary-adrenal axis function of proscar combined with selective serotonin reuptake inhibitor in post-stroke depression

Table 1 Comparison of Hamilton Depression Scale scores between groups, mean ± SD

Group	Cases	Pre-treatment	Post-treatment	T value	P value
Control	46	23.08 ± 1.17	8.68 ± 1.26	56.805	0.001
Study	46	23.12 ± 1.09	6.73 ± 1.12	71.128	0.000
T value		0.169	7.845
P value		0.866	0.000

Table 2 Comparison of traditional Chinese medicine evidence points after treatment between groups, mean ± SD

Group	Cases	Pre-treatment	Post-treatment	T value	P value
Control	46	26.78 ± 2.24	10.26 ± 1.35	42.841	0.000
Study	46	27.01 ± 2.18	7.32 ± 1.27	52.932	0.000
T value		0.499	10.758
P value		0.619	0.000

Table 3 Comparison of serum serotonin and norepinephrine levels before and after treatment between groups, mean ± SD

Group	Cases	Serotonin (ng/L)		T value	P value	Norepinephrine (ng/L)		T value	P value
		Pre-treatment	Post-treatment			Pre-treatment	Post-treatment
Control	46	324.31 ± 30.84	582.18 ± 41.93	33.601	0.000	92.28 ± 10.34	195.23 ± 21.09	29.727	0.000
Study	46	324.08 ± 31.72	649.71 ± 52.33	36.091	0.000	92.41 ± 10.22	218.07 ± 23.19	33.630	0.000
T value		0.035	6.830			0.061	4.941
P value		0.972	0.001			0.952	0.001

Table 4 Comparison of serum cortisol and corticotropin-releasing hormone levels before and after treatment between groups, mean ± SD

Group	Cases	Cortisol (μg/dL)		T value	P value	Corticotropin-releasing hormone (pg/mL)		T value	P value
		Pre-treatment	Post-treatment			Pre-treatment	Post-treatment
Control	46	11.42 ± 1.44	8.23 ± 1.05	12.140	0.000	305.38 ± 21.42	257.66 ± 18.29	11.491	0.000
Study	46	11.51 ± 1.37	6.84 ± 1.12	17.899	0.001	306.03 ± 22.26	198.28 ± 14.49	27.514	0.000
T value		0.307	6.141			0.143	17.259
P value		0.759	0.001			0.887	0.001

Table 5 Comparison of serum adrenocorticotropic hormone levels before and after treatment between groups, mean ± SD

Group	Cases	Adrenocorticotropic hormone (pg/mL)		T value	P value
		Pre-treatment	Post-treatment
Control	46	33.89 ± 2.29	26.39 ± 2.16	16.159	0.000
Study	46	34.02 ± 2.55	23.75 ± 2.09	21.126	0.000
T value		0.257	5.957
P value		0.797	0.001

Table 6 Comparison of the total effective rate of clinical treatment between groups, n (%)

Group	Cases	Cured	Markedly effective	Effective	Ineffective	Total effective
Control	46	10 (21.74)	16 (34.78)	13 (28.26)	7 (15.22)	39 (84.78)
Study	46	7 (15.22)	11 (23.91)	12 (26.09)	16 (34.78)	30 (65.22)

Table 7 Comparison of the incidence of adverse effects of treatment between groups, n (%)

Group	Cases	Nausea	Diarrhea	Insomnia	Total incidence
Control	46	3 (6.52)	1 (2.17)	1 (2.17)	5 (10.86)
Study	46	3 (6.52)	0 (0)	1 (2.17)	4 (8.69)
χ2					0.137
P value					0.711