Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived neurotrophic factor

doi:10.5498/wjp.v15.i2.99573

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 2

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (281)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-4) series.

Item

Count

PDF

HTML

112

Figures (1-1)

Tables (1-4)

Sum=222

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=41

Feb 19, 2025 (publication date) through Feb 3, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Psychiatry

ISSN

2220-3206

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Trials Study

World J Psychiatry. Feb 19, 2025; 15(2): 99573
Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.99573

Table 1 Comparison of negative emotions (mean ± SD, score)

Group	n	Somatization		Body weight change		Cognitive disorder		Diurnal fluctuation diurnal variation		Sluggish		Sleep disorder		Feeling of despair
Group	n	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After
Control	250	14.18 ± 2.46	11.39 ± 2.24^a	1.29 ± 0.35	0.84 ± 0.28^a	17.57 ± 2.42	13.15 ± 2.21^a	1.32 ± 0.27	0.71 ± 0.16^a	10.12 ± 2.27	7.37 ± 2.19^a	4.25 ± 0.82	2.03 ± 0.74^a	8.15 ± 2.09	5.13 ± 1.27^a
Observation	250	14.23 ± 2.30	10.87 ± 2.13^a	1.31 ± 0.28	0.79 ± 0.12^a	17.49 ± 2.36	12.61 ± 2.15^a	1.29 ± 0.31	0.68 ± 0.09^a	10.25 ± 2.30	6.89 ± 2.06^a	4.33 ± 0.76	1.87 ± 0.50^a	8.28 ± 2.14	4.85 ± 1.06^a
t		0.235	2.660	0.706	2.595	0.374	2.769	1.154	2.584	0.636	2.524	1.131	2.833	0.687	2.676
P value		0.815	0.008	0.481	0.010	0.708	0.006	0.249	0.010	0.525	0.012	0.258	0.005	0.492	0.008

^aP < 0.05 vs specific values before intervention in the same group.

Table 2 Comparison of serum inflammatory factors between the two groups (mean ± SD, ng/L)

Group	n	TNF-α		IL-1β		IL-6
Group	n	Before	After	Before	After	Before	After
Control	250	65.72 ± 5.48	54.89 ± 5.31^a	25.74 ± 3.26	21.56 ± 3.12^a	51.14 ± 5.39	47.13 ± 5.22^a
Observation	250	65.59 ± 5.37	53.62 ± 5.15^a	25.69 ± 3.30	20.84 ± 3.05^a	51.26 ± 5.40	45.84 ± 5.13^a
t		0.268	2.715	0.170	2.609	0.249	2.787
P value		0.789	0.007	0.865	0.009	0.840	0.006

^aP < 0.05 vs specific values against the same group before the intervention.

TNF-α: Tumor necrosis factor α; IL: Interleukin.

Table 3 Comparison of miR-155 expression levels between the two groups (mean ± SD)

Group	n	miR-155
Group	n	Before	After	t	P value
Control	250	5.89 ± 0.52	4.02 ± 0.35	47.171	< 0.001
Observation	250	5.91 ± 0.48	3.95 ± 0.21	59.150	< 0.001
t		0.447	2.712
P value		0.655	0.007

Table 4 Comparison of BDNF levels in the two groups (mean ± SD, ng/mL)

Group	n	Before	After	t	P value
Control	250	15.46 ± 1.03	20.80 ± 1.24	52.378	< 0.001
Observation	250	15.54 ± 1.10	21.09 ± 1.30	51.530	< 0.001
t		0.839	2.552
P value		0.402	0.011

Citation: Zhang Q, Zhao Y, Cheng GY. Effect of negative mood, serum inflammatory factors, miR-155, and brain-derived neurotrophic factor. World J Psychiatry 2025; 15(2): 99573
URL: https://www.wjgnet.com/2220-3206/full/v15/i2/99573.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i2.99573