Retrospective Study
Copyright ©The Author(s) 2024.
World J Psychiatry. Jul 19, 2024; 14(7): 1034-1042
Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1034
Table 1 Comparison of demographic data between the two groups, n (%)/mean ± SD
Item
Experimental group (n = 32)
Control group (n = 28)
t/χ2/Z
P value
Age (yr)59.45 ± 3.9459.87 ± 4.400.3900.697
Gender0.7650.381
    Man17 (53.13)18 (64.29)
    Woman15 (46.87)10 (35.71)
BMI (kg/m²)24.88 ± 3.6224.01 ± 3.270.9710.335
Smoking history13 (40.63)12 (42.85)0.0300.861
Drinking history5 (15.62)6 (21.42)0.3350.561
Side of lesion2.1160.145
    Left side17 (53.13)20 (71.43)
    Right side15 (46.87)8 (28.57)
Education background1.5580.119
    Junior high school and below24 (75.00)16 (57.14)
    Senior high school6 (18.75)7 (25.00)
    College and above2 (6.25)5 (17.86)
History of hypertension23 (71.87)19 (67.85)0.1140.734
History of coronary heart disease4 (12.50)3 (10.71)0.0350.850
History of atrial fibrillation5 (15.62)2 (7.14)0.3810.536
Table 2 Changes in Mini-Mental State Examination and Trail Making Test scores, mean ± SD
Item
Time (wk)
Experimental group (n = 32)
Control group (n = 28)
Inter-group comparison (F/P value)
Time comparison (F/P value)
Inter-group time interactive comparison (F/P value)
MMSE score018.45 ± 3.5218.84 ± 4.749.451/0.00237.030/< 0.0014.395/0.013
621.69 ± 3.24a,b19.32 ± 3.05b
1225.26 ± 2.38a,b22.12 ± 2.19b
TMT-A score082.35 ± 12.8481.66 ± 14.579.016/0.003193.200/< 0.0013.664/0.027
661.58 ± 10.25a,b71.34 ± 11.46b
1241.59 ± 5.32a,b46.75 ± 5.87b
TMT-B score0162.18 ± 45.25163.36 ± 42.165.332/0.02257.420/< 0.0011.151/0.318
6123.73 ± 23.11a,b141.39 ± 22.96b
1296.76 ± 16.33a,b109.42 ± 19.86b
Table 3 Changes in the latency and amplitude of P300, mean ± SD
GroupLatency (ms)
Amplitude (μv)
0 wk
6 wk
12 wk
0 wk
6 wk
12 wk
Experimental group (n = 32)452.38 ± 40.52402.31 ± 21.14a,b365 ± 15.13a,b4.53 ± 2.146.18 ± 1.74a,b6.89 ± 1.45a,b
Control group (n = 28)467.84 ± 43.99437.79 ± 22.57b384.23 ± 16.46b4.41 ± 2.085.22 ± 1.93b6.02 ± 1.66b
Inter-group comparison (F/P value)30.340/< 0.0015.556/0.019
Time comparison (F/P value)136.700/< 0.00117.600/< 0.001
Inter-group time interactive comparison (F/P value)2.179/0.1160.932/0.395
Table 4 Changes in growth factors, mean ± SD
Item
Time (wk)
Experimental group (n = 32)
Control group (n = 28)
Inter-group comparison (F/P value)
Time comparison (F/P value)
Inter-group time interactive comparison (F/P value)
BNDF (ng/mL)04.85 ± 0.794.92 ± 0.8319.330/< 0.001146.100/< 0.0019.113/< 0.001
66.63 ± 1.05a,b6.07 ± 0.86b
128.77 ± 1.25a,b7.28 ± 1.14b
TGF-β1 (ng/L)015.42 ± 2.5415.68 ± 2.9919.080/< 0.00192.220/< 0.0018.759/< 0.001
620.44 ± 3.12a,b18.56 ± 3.08b
1225.71 ± 3.52a,b21.13 ± 3.66b
GDNF (pg/mL)0288.61 ± 25.26282.74 ± 24.1840.080/< 0.001157.200/< 0.0016.016/0.003
6346.59 ± 25.84a,b312.72 ± 26.38b
12392.27 ± 29.96a,b355.06 ± 30.47b