Hao XQ, Yang XD, Qi Y. Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy. World J Psychiatry 2024; 14(7): 1017-1026 [PMID: 39050208 DOI: 10.5498/wjp.v14.i7.1017]
Corresponding Author of This Article
Yue Qi, MM, Department of Hematology, The Fourth Hospital of Hebei Medical University, No. 169 Tianshan Street, East Development Zone, Shijiazhuang 050011, Hebei Province, China. qi15931696485@163.com
Research Domain of This Article
Hematology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Jul 19, 2024; 14(7): 1017-1026 Published online Jul 19, 2024. doi: 10.5498/wjp.v14.i7.1017
Table 1 Demographic and clinical characteristics of study-eligible patients
Characteristics
Eligible, n = 62
Sex
Male
29
Female
33
Age in years
≤ 65
49
> 65
13
Education
High school or less
23
College
20
Bachelor’s degree
15
Graduate degree
4
ECOG performance status
< 2
8
≥ 2
7
BMI in kg/m2, median (IQR)
25.4 (22.2-28.7)
High serum LDH
9
High serum β2m
11
Table 2 Psychological symptom scores in patients with diffuse large B-cell lymphoma during chemotherapy
Item
Eligible, n = 62
Score
Restless sleep
58 (93.55)
4.51 ± 1.38
Sadness
57 (91.94)
4.77 ± 1.40
Forgetfulness
50 (80.65)
3.48 ± 1.12
Distress
58 (93.55)
4.53 ± 1.37
Numbness
30 (48.39)
3.47 ± 1.08
Table 3 Pittsburgh Sleep Quality Index and Five-Facet Mindfulness Questionnaire-Short Form of patients with diffuse large B-cell lymphoma during chemotherapy
Assessment measure
Scores
PSQI
10.49 ± 1.28
FFMQ-SF
49.85 ± 10.67
Table 4 Cancer-related fatigue status of patients with diffuse large B-cell lymphoma, n = 62
Dimension
Average score
Mild fatigue, n (%)
Moderate fatigue, n (%)
Severe fatigue, n (%)
Behavior fatigue
6.57 ± 2.43
18 (29.03)
35 (56.45)
9 (14.52)
Emotional fatigue
5.25 ± 2.14
15 (24.19)
29 (46.78)
34 (29.03)
Perceived fatigue
6.39 ± 2.36
20 (32.26)
32 (51.61)
10 (16.13)
Cognitive fatigue
5.37 ± 2.48
25 (40.32)
21 (33.87)
16 (25.81)
Total CRF score
5.74 ± 2.51
24 (38.71)
26 (41.94)
12 (19.35)
Table 5 Univariate analysis of cancer-related fatigue in patients with diffuse large B-cell lymphoma
Influencing factors
Eligible, n = 62
Average PFS score
P value
Sex
0.543
Male
29
5.44 ± 2.32
Female
33
5.74 ± 2.20
Age in years
0.095
≤ 65
49
4.59 ± 1.25
> 65
13
5.15 ± 2.42
Marital status
0.206
Married
21
5.57 ± 2.34
Unmarried
40
5.95 ± 2.53
Others
1
6.54 ± 2.32
Education
0.390
High school or less
23
4.39 ± 1.60
College
20
4.37 ± 1.38
Bachelor’s degree
15
5.07 ± 2.21
Graduate degree
4
5.93 ± 2.52
Self-efficacy level
26
0.031
High
26
4.66 ± 1.71
Medium
9
5.56 ± 2.30
Low
5.90 ± 2.51
Anxiety and depression degree
0.033
Mild
20
4.72 ± 1.32
Moderate
29
5.50 ± 2.53
Severe
13
5.97 ± 2.85
Tumor staging
0.001
Stage I
25
4.34 ± 1.55
Stage II
14
5.64 ± 2.19
Stage III
13
5.82 ± 2.44
Stage IV
10
6.78 ± 3.13
Chemotherapy cycle
0.006
First cycle
23
4.09 ± 1.13
Second cycle
19
4.52 ± 1.40
Third cycle
11
5.72 ± 2.37
Fourth cycle
9
6.46 ± 3.50
Pain degree
0.004
Mild
15
4.54 ± 1.75
Moderate
37
5.48 ± 2.44
Severe
10
6.31 ± 3.47
Table 6 Cancer-related fatigue-related symptoms during chemotherapy in the study patients
Items
Eligible, n = 62
Score
Fatigue
59 (95.16)
4.48 ± 1.47
Pain
51 (82.26)
4.42 ± 1.48
Dry mouth
55 (88.71)
4.35 ± 1.32
Lethargy
54 (87.10)
4.08 ± 1.34
Shortness of breath
28 (45.16)
3.52 ± 1.16
Table 7 Perceptual control scores in patients with diffuse large B-cell lymphoma during chemotherapy
Items
Score
Cancer experience
Personal experience
13.71 ± 1.98
Social experience
24.01 ± 3.02
Emotional experience
21.51 ± 3.12
Cancer efficacy
Personal efficacy
15.71 ± 4.66
Collective efficacy
18.28 ± 4.72
Medical care efficacy
11.63 ± 2.03
Table 8 Factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy
Factor
Regression coefficient
Wald χ2 value
P value
OR
Tumor staging
0.459
5.440
0.015
1.583
Chemotherapy cycle
0.233
4.629
0.003
1.339
Self-efficacy level
0.559
8.429
0.004
1.274
Anxiety and depression level
0.460
8.340
0.001
1.674
Citation: Hao XQ, Yang XD, Qi Y. Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy. World J Psychiatry 2024; 14(7): 1017-1026