Huang ZY, Lyu ZP, Li HG, You HZ, Yang XN, Cha CH. Des-Arg(9) bradykinin as a causal metabolite for autism spectrum disorder. World J Psychiatry 2024; 14(1): 88-101 [PMID: 38327885 DOI: 10.5498/wjp.v14.i1.88]
Corresponding Author of This Article
Zhong-Yu Huang, MD, PhD, Assistant Professor, Research Fellow, Center for Medical Research on Innovation and Translation, Institute of Clinical Medicine, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, No. 1 Panfu Road, Yuexiu District, Guangzhou 510000, Guangdong Province, China. zy1717086@163.com
Research Domain of This Article
Mathematical & Computational Biology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 2 Nominally significant results of the inverse variance weighted method
ID
Metabolite
Outcome
SNP, n
β
SE
P value
M02137
Biliverdin
ASD
3
-0.255
0.122
0.038
M20675
1,5-Anhydroglucitol
ASD
5
-0.881
0.407
0.031
M32412
Butyrylcarnitine
ASD
12
-0.219
0.111
0.049
M32497
10-undecenoate (11:1n1)
ASD
3
0.546
0.258
0.034
M32847
X-11530
ASD
3
-0.302
0.125
0.016
M33137
X-11792
ASD
3
0.388
0.093
3.03 × 10-5
M33138
Oxidized bilirubin
ASD
3
-0.318
0.148
0.032
M34306
X-12696
ASD
4
-0.831
0.325
0.011
M34407
Isovalerylcarnitine
ASD
4
-0.976
0.393
0.013
M34420
Des-Arg(9) bradykinin
ASD
3
0.262
0.064
4.64 × 10-5
M36131
Alpha-glutamyltyrosine
ASD
3
-0.619
0.213
0.004
Table 3 Heterogeneity and pleiotropy tests of the 8 metabolites
Metabolite
Heterogeneity, MR Egger P value
Heterogeneity, IVW P value
Pleiotropy, P value
Biliverdin
0.392
0.415
0.496
1,5-anhydroglucitol
0.482
0.034
0.067
Butyrylcarnitine
0.174
0.007
0.016
10-Undecenoate (11:1n1)
0.844
0.689
0.556
Oxidized bilirubin
0.271
0.385
0.586
Isovalerylcarnitine
0.030
0.058
0.744
Des-Arg(9) bradykinin
0.663
0.906
0.949
Alpha-glutamyltyrosine
0.785
0.923
0.817
Table 4 Top 10 predicted targets of Des-Arg(9)-bradykinin in SwissTargetPrediction
Target
Common name
Target class
Probability
Bradykinin B1 receptor
BDKRB1
Family A G protein-coupled receptor
0.420
Neurotensin receptor 1
NTSR1
Family A G protein-coupled receptor
0.189
Thrombin
F2
Protease
0.169
HLA class I histocompatibility antigen A-3
HLA-A
Surface antigen
0.140
Mu opioid receptor
OPRM1
Family A G protein-coupled receptor
0.131
Delta opioid receptor
OPRD1
Family A G protein-coupled receptor
0.131
Kappa opioid receptor
OPRK1
Family A G protein-coupled receptor
0.122
Neurotensin receptor 2
NTSR2
Family A G protein-coupled receptor
0.122
HLA class II histocompatibility antigen DRB3-1
HLA-DRB3
Surface antigen
0.122
Cyclin-dependent kinase 2/cyclin A
CDK2, CCNA1, CCNA2
Other cytosolic protein
0.122
Citation: Huang ZY, Lyu ZP, Li HG, You HZ, Yang XN, Cha CH. Des-Arg(9) bradykinin as a causal metabolite for autism spectrum disorder. World J Psychiatry 2024; 14(1): 88-101