Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression

Table 1 Comparison of general data [n (%), mean ± SD]

Feature	Heavy group (n = 90)	Mild to moderate group (n = 210)	χ2/t value	P value
Gender (male/female)	48/42	109/101	0.052	0.820
Age (yr)	45.29 ± 4.56	46.37 ± 5.44	-1.773	0.078
BMI (kg/m2)	22.48 ± 2.17	22.19 ± 2.13	1.114	0.266
Abdominal distension (Yes/No)	51/39	102/108	1.652	0.199
Abdominal pain (Yes/No)	43/47	100/110	0.001	0.980
Belching (Yes/No)	40/50	107/103	1.068	0.301
Nausea (Yes/No)	38/52	98/112	0.502	0.479
Vomiting (Yes/No)	46/44	105/105
Sleep disorder (Yes/No)	47/43	85/125	3.528	0.060
Family history of depression (Yes/No)	45/45	48/162	21.699	< 0.001

BMI: Body mass index.

Table 2 Comparison of immune function indicators between the two groups (mean ± SD)

Index	Heavy group (n = 90)	Mild to moderate group (n = 210)	T value	P value
IgA (g/L)	1.86 ± 0.42	2.54 ± 0.63	-10.791	< 0.001
IgM (g/L)	2.97 ± 0.62	3.59 ± 0.65	-7.698	< 0.001
IgG (g/L)	15.37 ± 3.48	15.42 ± 3.52	-0.113	0.910
CD4+ (%)	32.16 ± 5.31	38.48 ± 5.49	-9.218	< 0.001
CD8+ (%)	29.37 ± 3.52	23.59 ± 3.13	6.800	< 0.001
CD4+/CD8+ ratio	1.24 ± 0.27	1.67 ± 0.36	-11.104	< 0.001

IgA: Immunoglobulin A; IgM: Immunoglobulin M; IgG: Immunoglobulin G.

Table 3 Comparison of gastrointestinal hormone indexes between the two groups (mean ± SD)

Group	n	GAS (pg/mL)	CCK (ng/L)	MTL (pg/mL)
Heavy group	90	43.52 ± 5.79	154.49 ± 11.68	256.28 ± 13.12
Mild to moderate group	210	52.44 ± 6.23	167.25 ± 13.54	258.18 ± 20.47
t value		-11.598	-7.781	-0.960
P value		< 0.001	< 0.001	0.338

GAS: Gastrin; CCK: Cholecystokinin; MTL: Motilin.

Table 4 The assignments of related indicators

Index	Code	Description of valuation
Family history of depression	X1	1 = Yes; 0 = No
IgA	X2	Enter actual value
IgM	X3	Enter actual value
CD4+	X4	Enter actual value
CD8+	X5	Enter actual value
CD4+/CD8+ ratio	X6	Enter actual value
GAS	X7	Enter actual value
CCK	X8	Enter actual value

IgA: Immunoglobulin A; IgM: Immunoglobulin M; GAS: Gastrin; CCK: Cholecystokinin.

Table 5 Multi-factor analysis

Index	β	SE	Wald χ2	P value	OR (95%CI)
Family history of depression	0.744	0.551	1.822	1.770	2.103 (0.714-6.193)
IgA	-2.703	0.600	20.313	< 0.001	0.067 (0.021-0.217)
IgM	-1.509	0.487	9.586	0.002	0.221 (0.085-0.575)
CD4+	0.151	0.218	0.482	0.488	1.163 (0.759-1.782)
CD8+	-0.286	0.290	0.969	0.325	0.751 (0.425-1.327)
CD4+/CD8+ ratio	-9.136	5.432	12.829	0.093	0.000 (0.000-4.525)
GAS	0.267	0.050	28.147	< 0.001	0.766 (0.694-0.845)
CCK	0.093	0.024	15.137	< 0.001	0.911 (0.869-0.955)
Constant	52.073	10.637	23.963	< 0.001	-

IgA: Immunoglobulin A; IgM: Immunoglobulin M; GAS: Gastrin; CCK: Cholecystokinin; OR: Odds ratio; CI: Confidence interval.