Major depressive disorder is correlated with the mitochondrial ND1 T3394C mutation in two Han Chinese families: Two case reports

Table 1 Summary of clinical molecular data for two probands carrying the ND1 T3394C mutation

Subject	Gender	Age at testing (yr)	Age at onset (yr)	First episode	History of suicide attempt	HDRS	Level of depression	mtDNA haplogroup
NB011-Ⅱ-4	F	62	50	N	N	21	Moderate	M9a3
NB054-Ⅲ-4	M	20	12	N	Y	39	Severe	M9a

HDRS: Hamilton depression rating scale.

Table 2 mtDNA mutations in two Chinese pedigrees with major depressive disorder

Gene	Positon	Replacement	Conservationa (H/B/M/X)	CRSb	NB011	NB054	Previously reportedc
D-loop	73	A-G		A	G	G	Y
	146	T-C		T	C	C	Y
	153	A-G		A	G	G	Y
	263	A-G		A	G	G	Y
	309	C-CCT		C		CCT	Y
	310	T-C		T	TC	C	Y
	489	T-C		T	C	C	Y
	16223	C-T		C	T	T	Y
	16234	C-T		C	T	T	Y
	16291	C-T		C	T		Y
	16316	A-G		A	G	G	Y
	16362	T-C		T	C	C	Y
12S rRNA	750	A-G	A/A/A/-	A	G	G	Y
	1041	A-G	A/T/T/T	A	G	G	Y
	1438	A-G	A/A/A/G	A	G	G	Y
16S rRNA	2706	A-G	A/G/A/A	A	G	G	Y
ND1	3394	T-C (Tyr30His)	Y/Y/Y/Y	T	C	C	Y
	4216	T-C (Tyr304His)	Y/H/H/H	T	C		Y
ND2	4491	G-A (Val8Ile)	V/I/I/V	G	A	A	Y
	4769	A-G		A	G	G	Y
CO1	7028	C-T		C	T	T	Y
	7142	T-C		T	C		Y
CO2	7861	T-C		T	C		Y
ATP6	8701	A-G (Thr59Ala)	T/S/L/Q	A	G	G	Y
	8728	TG-T (Trp68Gly)	W/W/W/W	TG		T	N
	8860	A-G (Thr112Ala)	T/A/A/T	A	G	G	Y
	9136	A-G (Ile204Val)	I/F/F/I	A		G	N
CO3	9242	A-G		A	G		Y
	9540	T-C		T	C	C	Y
ND3	10398	A-G (Thr114Ala)	T/T/T/A	A	G	G	Y
	10400	C-T		C	T	T	Y
ND4	10873	T-C		T	C	C	Y
	11719	G-A		G	A	A	Y
ND5	12705	C-T		C	T	T	Y
ND6	14308	T-C		T	C	C	Y
	14417	A-G (Val86Ala)	V/K/W/S	A	G		Y
CYTB	14766	C-T (Thr7Ile)	T/S/T/S	C	T	T	Y
	14783	T-C		T	C	C	Y
	15043	G-A		G	A	A	Y
	15301	G-A		G	A	A	Y
	15326	A-G (Thr194Ala)	T/M/I/I	A	G	G	Y

^aConservation of amino acids for polypeptides or nucleotides for RNAs in human, bovine, mouse, and Xenopus laevis.

^bCambridge reference sequence (Andrews et al[14], 1999).

^cSee online mitochondrial genome databases http://www.mitomap.org and http://www.genpat.uu.se/mtDB/.

CRS: Cambridge reference sequence; H: Human; B: Bovine; M: Mouse; X: Xenopus laevis.