Ma J, Song XQ. Correlation between cognitive impairment and metabolic imbalance of gut microbiota in patients with schizophrenia. World J Psychiatry 2023; 13(10): 724-731 [PMID: 38058688 DOI: 10.5498/wjp.v13.i10.724]
Corresponding Author of This Article
Xue-Qin Song, PhD, Chief Physician, Department of Psychiatry, The First Affiliated of Zhengzhou University, No. 1 Jian Dong Road, Zhengzhou 450052, Henan Province, China. sxq907907@163.com
Research Domain of This Article
Psychiatry
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Oct 19, 2023; 13(10): 724-731 Published online Oct 19, 2023. doi: 10.5498/wjp.v13.i10.724
Table 1 Relative abundance of gut microbiota at the phylum level in the two groups
Name of bacteria
Case group, n = 498
Control group, n = 498
T value
P value
Actinomycetota
2.95 ± 5.62
2.18 ± 3.60
2.575
0.01
Bacteroidota
34.27 ± 19.53
26.84 ± 16.07
6.556
0.001
Euryarchaeota
0.16 ± 0.57
0.00 ± 0.00
6.264
0.001
Bacillota
48.82 ± 17.96
61.37 ± 14.49
12.14
0.001
Fusobacteria
0.08 ± 0.57
0.02 ± 0.07
2.332
0.019
Pseudomonadota
15.82 ± 20.13
7.68 ± 11.59
7.82
0.001
Saccharibacteria
0.49 ± 0.27
0.01 ± 0.01
39.65
0.001
Tenericutes
0.23 ± 1.14
0.59 ± 1.92
3.598
0.001
Verrucomicrobia
0.57 ± 1.94
1.62 ± 5.19
4.229
0.001
Actinomycetota
2.95 ± 5.62
2.18 ± 3.60
2.575
0.01
Table 2 Relative abundance of gut microbiota at the class level in the two groups
Name of bacteria
Case group, n = 498
Control group, n = 498
T value
P value
Class Actinobacteria
2.81 ± 5.64
1.56 ± 2.81
4.427
0.001
Bacilli
2.01 ± 4.28
2.67 ± 5.60
2.090
0.036
Bacteroidia
31.28 ± 19.67
26.68 ± 16.18
4.030
0.001
Betaproteobacteria
1.50 ± 3.29
0.39 ± 0.52
7.437
0.001
Clostridia
45.92 ± 18.62
58.18 ± 13.92
11.770
0.001
Coriobacteriia
0.21 ± 0.49
0.58 ± 1.29
5.984
0.001
Proteobacteria
0.29 ± 0.39
0.15 ± 0.24
6.822
0.001
Blastomycetes
0.96 ± 1.19
0.67 ± 1.20
3.829
0.01
Gammaproteobacteria
13.84 ± 19.67
6.92 ± 11.37
6.797
0.001
Verrucomicrobiae
0.58 ± 1.69
1.82 ± 5.86
4.537
0.001
Table 3 Comparative analysis of cognitive scores between the two groups
Cognitive domain
Case group, n = 498
Control group, n = 498
T value
P value
Attention/alertness
40.27 ± 6.29
51.98 ± 9.92
22.250
0.001
Learning
36.27 ± 10.01
50.69 ± 10.08
22.650
0.001
Memory
40.31 ± 11.26
54.27 ± 7.19
23.320
0.001
Fine motors
37.29 ± 13.27
59.06 ± 7.91
31.450
0.001
Social cognition
41.09 ± 11.08
54.26 ± 10.87
18.930
0.001
Executive function
40.18 ± 7.04
52.37 ± 5.09
31.310
0.001
Conversion
41.06 ± 7.21
49.57 ± 7.61
18.120
0.001
Inhibition
38.62 ± 9.51
54.63 ± 9.67
26.340
0.001
Planning
42.14 ± 13.01
52.67 ± 10.17
14.230
0.001
Working memory
42.09 ± 13.02
53.19 ± 9.06
15.620
0.001
Category fluency
39.86 ± 10.05
53.18 ± 9.07
21.960
0.001
Information processing
33.43 ± 9.14
48.45 ± 7.39
28.520
0.001
Total score
40.64 ± 7.17
51.14 ± 5.29
26.300
0.001
Table 4 Correlation analysis between the total cognitive score and gut microbiota at the phylum level
Name of bacteria
Total cognitive score
R value
P value
Actinomycetota
6.591
0.001
Bacteroidota
5.625
0.016
Euryarchaeota
6.281
0.183
Bacillota
0.976
0.281
Fusobacteria
2.190
0.026
Pseudomonadota
6.364
0.018
Saccharibacteria
5.196
0.037
Tenericutes
0.623
0.001
Verrucomicrobia
0.191
0.006
Table 5 Correlation analysis between the total cognitive score and gut microbiota at the class level
Name of bacteria
Total cognitive score
R value
P value
Actinobacteria
3.257
0.001
Bacilli
0.981
0.001
Bacteroidia
6.294
0.001
Betaproteobacteria
6.281
0.016
Clostridia
0.124
0.015
Coriobacteriia
0.293
0.019
Proteobacteria
6.270
0.008
Blastomycetes
5.671
0.006
Gammaproteobacteria
4.195
0.005
Verrucomicrobiae
0.549
0.010
Citation: Ma J, Song XQ. Correlation between cognitive impairment and metabolic imbalance of gut microbiota in patients with schizophrenia. World J Psychiatry 2023; 13(10): 724-731