Serum levels of chemokines in adolescents with major depression treated with fluoxetine

Table 1 Demographics and episodic data of the study sample

	HVs, n = 18	Patients, n = 22
Age in yr	18.9 ± 1.2	17.1 ± 2.3
Gender, male/female	4/14	4/18
BMI in kg/m2	23.2 ± 2.1	23.1 ± 2.1
Education in yr	12.9 ± 1.2	11.5 ± 2.6
Family history, yes/no	3/15	8/14
First episode	N/A	8
Recurrent episode	N/A	14

Values are presented as mean ± standard deviation. BMI: Body mass index; HVs: Healthy volunteers; N/A: Not applicable.

Table 2 Clinical psychiatric scores and serum chemokine levels in adolescents with major depressive disorder in 8 wk of selective serotonin reuptake inhibitor treatment

Chemokine serum levels, pg/mL	HVs	Adolescents with MDD			Post hoc statistical analysis
	n = 18	0 wk, n = 22	4 wk, n = 22	8 wk, n = 22	0 wk vs HVs	4 wk vs 0 wk	8 wk vs 0 wk
MCP-1 or CCL2	48.1 ± 3.7	107.7 ± 31.0	89.8 ± 19.9	102.9 ± 14.0	dP < 0.0001	aP < 0.05	NS
MIP-1α or CCL3	5.4 ± 1.0	7.3 ± 1.4	6.7 ± 1.4	7.4 ± 1.0	dP < 0.0001	NS	NS
MIP-1β or CCL4	204.7 ± 42.2	324.0 ± 61.5	311.8 ± 48.1	294.8 ± 34.8	dP < 0.0001	NS	NS
IL-8 or CXCL8	50.2 ± 6.8	79.2 ± 18.0	66.9 ± 13.2	73.3 ± 9.1	dP < 0.0001	NS	NS
IP-10 or CXCL10	1890.0 ± 52.7	2309.0 ± 545.1	2224.0 ± 578.5	2710.0 ± 220.1	aP < 0.05	NS	aP < 0.05
Eotaxin or CCL11	255.4 ± 50.4	319.8 ± 65.5	277.2 ± 51.8	328.6 ± 50.7	bP < 0.01	NS	NS
Clinical psychiatric scale
HDRS	N/A	19.4 ± 4.7	9.1 ± 4.72	6.0 ± 2.4	N/A	dP < 0.0001	dP < 0.0001

Values are presented as mean ± standard deviation. To compare differences between means, the homogeneity of variance test was employed in all cases, followed by one-way analysis of variance with Bonferroni's post hoc test when the variances were equal and Dunnett T3 test when the variances were not equal. Statistical significance was attributed when

^aP < 0.05;

^bP < 0.01 and

^dP < 0.0001. N/A: Not applicable; NS: Not significant. HDRS: Hamilton depression rating scale; IL-8: Interleukin-8; IP-10: Interferon gamma-induced protein 10; MCP-1: Monocyte chemoattractant protein-1; MDD: Major depressive disorder; MIP: Macrophage inflammatory protein.