Tardive dyskinesia-depression association in Chinese patients with chronic schizophrenia: The mediating role of insomnia and gender differences

doi:10.5498/wjp.117824

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Jul 19, 2026; 16(7): 117824
Published online Jul 19, 2026. doi: 10.5498/wjp.117824

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Figure 1 Mediation model for the relationship between tardive dyskinesia and depression, with insomnia as a mediator. a: The effect of tardive dyskinesia on insomnia; b: The effect of insomnia on depression; c: The total effect of tardive dyskinesia on depression; c’: The direct effect of tardive dyskinesia on depression after controlling for insomnia; TD: Tardive dyskinesia.

Citation: Xiao SR, Yin QY, Zhu JM, Liu Y, Tan WZ, Wang T, Zhang XY. Tardive dyskinesia-depression association in Chinese patients with chronic schizophrenia: The mediating role of insomnia and gender differences. World J Psychiatry 2026; 16(7): 117824
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/117824.htm
DOI: https://dx.doi.org/10.5498/wjp.117824

Xiao SR, Yin QY, Zhu JM, Liu Y, Tan WZ, Wang T, Zhang XY. Tardive dyskinesia-depression association in Chinese patients with chronic schizophrenia: The mediating role of insomnia and gender differences. World J Psychiatry 2026; 16(7): 117824 [DOI: 10.5498/wjp.117824]

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