Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival

doi:10.5498/wjp.v16.i6.118149

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Jun 19, 2026; 16(6): 118149
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.118149

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Figure 1 Molecular mechanisms of metabolic disorders caused by antipsychotics. Atypical antipsychotics carry the risk of inducing both insulin secretion dysfunction due to endoplasmic reticulum response stress and insulin resistance due to histamine H1 receptor and serotonin 5-hydroxytryptamine receptor 2C receptor inhibition. ERS: Endoplasmic reticulum stress; ER: Endoplasmic reticulum; 5-HT2C: 5-hydroxytryptamine receptor 2C.

Citation: Nagamine T. Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival. World J Psychiatry 2026; 16(6): 118149
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/118149.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.118149

Nagamine T. Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival. World J Psychiatry 2026; 16(6): 118149 [DOI: 10.5498/wjp.v16.i6.118149]

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