Progress on the neurotrophic effects of antidepressant drugs

Figure 1 Schematic diagram of mechanistic integration of antidepressant therapy via the brain-derived neurotrophic factor-tropomyosin receptor kinase B and mammalian target of rapamycin pathways. SSRI: Selective serotonin reuptake inhibitor; NMDA: N-methyl-D-aspartate; ECT: Electroconvulsive therapy; BDNF: Brain-derived neurotrophic factor; mTOR: Mammalian target of rapamycin; TrkB: Tropomyosin receptor kinase B; GDNF: Glial cell line-derived neurotrophic factor; HNK: Hydroxynorketamine; AMPAR: Α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; VEGF: Vascular endothelial growth factor; DG: Dentate gyrus; MDD: Major depressive disorder.