Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma: Systematic review and meta-analysis

Figure 1 Studies included and excluded from the meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. RCT: Randomized clinical trial.

Figure 2 Risk of bias in included studies. A: Risk of bias summary: Each bias risk item of all included studies was judged by review authors; B: Risk of bias graph: The review authors quantified each bias risk item of included studies as a percentage. The risk of bias assessment for each included study in accordance with “Cochrane RoB 2”. Low risk (+), unclear (?), and high risk (-).

Figure 3 Forest plot of major depressive disorder after selective serotonin reuptake inhibitor treatment of traumatic brain injury. A: Forest plot of the reduction in depression scores of major depressive disorder (MDD) after selective serotonin reuptake inhibitor (SSRI) treatment of traumatic brain injury (TBI); B: Forest plot of the incidence of adverse reactions in SSRI-treated MDD after TBI. Diamond: Pooled estimate; squares: Individual study effects; horizontal lines: Confidence intervals; MDD: Major depressive disorder; SSRI: Selective serotonin reuptake inhibitor.

Figure 4 The funnel plot of this study. A: The reduction in depression scores of major depressive disorder; B: Adverse reactions. OR: Odds ratio.