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Huang R, Ge H, Nie G, Li A, Liu L, Cheng L, Zhang M, Cheng H. Effect of Behavioral Activation on Stigma and Quality of Life in Patients With Advanced Esophageal and Gastric Cancer: A Randomized Controlled Trial. Psychooncology 2024; 33:e70021. [PMID: 39547955 DOI: 10.1002/pon.70021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Revised: 10/19/2024] [Accepted: 10/27/2024] [Indexed: 11/17/2024]
Abstract
BACKGROUND Esophageal cancer and gastric cancer patients require researchers' attention to address and resolve the issue of stigma. The aim of this study was to investigate whether behavioral activation (BA), an emerging psychosocial intervention method, can mitigate the stigma experienced by these patients and enhance their quality of life (QoL). METHODS One hundred fifty-three patients with advanced esophageal cancer and gastric cancer were recruited and randomly assigned to either the BA plus care as usual group (BA + CAU group) or the care as usual group (CAU group). Pre- and post-intervention questionnaires, including the Social Impact Scale (SIS), as well as all functional areas and global health and QoL modules from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30, version3). RESULTS Generalized estimating equation analysis revealed that compared to usual care alone, combining BA with usual care significantly reduced stigma (time-by-group interaction, T1: β = -10.584, p < 0.001; T2: β = -22.619, p < 0.001) while improving physical, role, emotional, social functioning and global health and QoL particularly at T2 time point. Additionally, it also has the potential to decelerate the progressive decline of cognitive functioning. Furthermore, correlation analysis demonstrated a significant association between stigma levels and all functional areas as well as global health and QoL. CONCLUSION The issue of stigma among esophageal cancer and gastric cancer patients warrants increased attention due to its close relationship with patient QoL. This study presents a promising psychosocial intervention approach suitable for clinical application that deserves further promotion among cancer patients. TRIAL REGISTRATION NCT06348940.
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Affiliation(s)
- Runze Huang
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- Anhui Medical University, Hefei, China
| | - Han Ge
- Anhui Medical University, Hefei, China
- School of Nursing, Anhui Medical University, Hefei, China
| | - Guodong Nie
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- Anhui Medical University, Hefei, China
| | - Anlong Li
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- Anhui Medical University, Hefei, China
| | - Lijun Liu
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- Anhui Medical University, Hefei, China
| | - Ling Cheng
- Medical Intensive Care Unit, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China
| | - Mingjun Zhang
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
| | - Huaidong Cheng
- Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China
- Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen, China
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Wang Q, Jia D, Gao Y, Zhou M, Zhao X, Qin R, Kong L, Li P. Relationship between stigma and infertility-related stress among couples undergoing AID: The mediating role of communication patterns. Stress Health 2024; 40:e3412. [PMID: 38651677 DOI: 10.1002/smi.3412] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Revised: 03/15/2024] [Accepted: 04/12/2024] [Indexed: 04/25/2024]
Abstract
Infertility can be stressful for infertile couples. This study aims to examine the intra-dyadic associations between stigma, communication patterns, and infertility-related stress in couples undergoing artificial insemination by donor semen (AID). This cross-sectional study was conducted from January to April 2021. Two hundred and three couples undergoing AID were recruited from a reproductive centre in China. All of the couples completed a two-item stigma questionnaire, Communication Pattern Questionnaire, and Fertility Problem Inventory. The actor-partner interdependence mediation analysis was performed using AMOS 23.0. The analysis demonstrated significant actor-actor effects for couples undergoing AID. More specifically, higher levels of stigma among wives and husbands were associated with more negative communication patterns, thereby increasing their own infertility-related stress. Simultaneously, there was a significant partner-actor effect among infertile wives, demonstrating that the husband's stigma can affect his wife's infertility-related stress by influencing her communication patterns. Couples undergoing AID experience increased infertility-related stress when they have high levels of stigma and negative communication patterns, and husbands' stigma is correlated to wives' communication patterns. Therefore, dyadic interventions aiming to improving stigma and enhancing positive communication may be conducive to reducing infertility-related stress.
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Affiliation(s)
- Qing Wang
- School of Management and Economics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
| | - Dongmei Jia
- State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China
| | - Yiming Gao
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Miao Zhou
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Xiangyu Zhao
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Rui Qin
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Linghua Kong
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Ping Li
- Department of Health Psychology, School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
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Yuan W, Jiang Y, Sun M, Zhao Q, Qiao G, Zheng Y. Factors influencing social avoidance and distress after radical lung cancer resection: a mediation analysis. Am J Transl Res 2024; 16:4770-4778. [PMID: 39398552 PMCID: PMC11470348 DOI: 10.62347/attp3522] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/13/2024] [Accepted: 08/12/2024] [Indexed: 10/15/2024]
Abstract
OBJECTIVE To investigate factors influencing social avoidance and distress (SAD) in patients following radical resection of lung cancer (RRLC) and analyze the mediating effects among these factors. METHODS Clinical data from 320 patients who underwent RRLC between January 2022 and December 2023 at the General Hospital of Western Theater Command PLA were analyzed. Data were collected using the General Information Questionnaire, Social Avoidance and Distress Scale (SADS), Hospital Anxiety and Depression Scale (HADS), Perceived Social Support Scales (PSSS), General Self-Efficacy Scale (GSES), and Consumer Experiences of Stigma Questionnaire (CESQ). Spearman correlation analysis explored the relationships between SAD, anxiety and depression, social support, self-efficacy, and stigma. Multiple linear regression identified factors influencing SAD. The PROCESS tool was used to test the mediating effects of these factors. RESULTS The mean SADS score was 16.73±4.69. SAD was positively correlated with anxiety, depression, and stigma (r=0.662, P<0.001; r=0.687, P<0.001) and negatively correlated with self-efficacy and social support (r=-0.682, P<0.001; r=-0.705, P<0.001). Multiple linear regression indicated that anxiety, depression, social support, self-efficacy, and stigma were significant influencers of SAD (β=0.132, P<0.001; β=-0.078, P<0.001; β=-0.178, P<0.001; β=0.115, P=0.002). Mediation analysis revealed that anxiety and depression directly affected SAD and indirectly influenced SAD through social support, stigma, and self-efficacy, both independently and via chain mediation (P<0.05). CONCLUSIONS Patients post-RRLC generally exhibit moderate SAD levels. Anxiety and depression directly influence SAD and also indirectly through the mediating effects of social support, stigma, and self-efficacy. Therefore, reducing depression and stigma while enhancing social support and self-efficacy is crucial for alleviating SAD in these patients.
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Affiliation(s)
- Wanshi Yuan
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
| | - Yunqin Jiang
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
| | - Mengyao Sun
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
| | - Qin Zhao
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
| | - Guobing Qiao
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
| | - Yifeng Zheng
- Department of Chest Surgery, The General Hospital of Western Theater Command PLA Chengdu 610083, Sichuan, China
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Tang N, Pei M, Liu H, Chen J, Wang Y, Xie L, Hu J, Wang J, Gao Y. Infertility-Related Stress, and Dyadic Coping as Predictors of Quality of Life: Gender Differences Among Couples with Infertility Issues. Int J Womens Health 2024; 16:1265-1276. [PMID: 39081285 PMCID: PMC11288320 DOI: 10.2147/ijwh.s469513] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/18/2024] [Accepted: 07/18/2024] [Indexed: 08/02/2024] Open
Abstract
Background The purpose of this study was to explore the relationship between infertility-related stress and dyadic coping with quality of life (QoL) in couples with infertility issues, and verify gender differences and dyadic interactions in the associations between them. Methods This cross-sectional study included 340 couples who were recruited from the First Affiliated Hospital of Lanzhou University between March 2022 and November 2022. The Fertility Problem Inventory, Dyadic Coping Inventory and FertiQoL were used to measure infertility-related stress, dyadic coping and QoL. The Actor-Partner Interdependence Model was used to analyze the effects of infertility-related stress and dyadic coping on the couple's own QoL (actor effect) as well as on their partner's QoL (partner effect). Results Female patients perceived significantly lower levels of QoL and dyadic coping than those of husbands. There was no statistically significant difference in the infertility-related stress between wives and husbands. Husbands' infertility-related stress had actor and partner effects on their own and their wives' QoL, while wives' infertility-related stress only had an actor effect on their own QoL. Husbands' dyadic coping had both actor effect and partner effects on their own and their wives' QoL, meanwhile wives' dyadic coping had both actor effect and partner effects on their own and their husbands' QoL. Conclusion Husbands' QoL was impacted by their own infertility-related stress, dyadic coping and their wives' dyadic coping. Whereas wives' QoL was influenced by infertility-related stress and dyadic coping from both their own and their spouses. Therefore, elevating the level of dyadic coping may contribute to improving QoL for both husbands and wives. Moreover, enhancing the ability to cope with infertility-related stress might be useful for husbands and indirectly contribute to wives' QoL.
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Affiliation(s)
- Nan Tang
- Department of Nursing, 1st Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
| | - Mengyue Pei
- School of Medicine, Henan Kaifeng College of Science Technology and Communication, Kaifei, Henan Province, People’s Republic of China
| | - Huihui Liu
- School of Nursing, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China
| | - Jingru Chen
- Department of Nursing, 1st Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
| | - Youting Wang
- Department of Nursing, 1st Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
| | - Lei Xie
- Renji Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China
| | - Junping Hu
- School of Nursing, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China
- Department of Reproductive Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China
| | - Jing Wang
- Department of Gynecology, 1th Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
| | - Yuan Gao
- Department of Nursing, 1st Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
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Tang X, Chen SQ, Huang JH, Deng CF, Zou JQ, Zuo J. Assessing the current situation and the influencing factors affecting perceived stigma among older patients after leukemia diagnosis. World J Psychiatry 2024; 14:812-821. [PMID: 38984333 PMCID: PMC11230094 DOI: 10.5498/wjp.v14.i6.812] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/20/2024] [Revised: 04/13/2024] [Accepted: 04/25/2024] [Indexed: 06/19/2024] Open
Abstract
BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia, with patients potentially facing stigmatization after diagnosis. However, there is limited research on the stigma experienced by these patients and the factors that may contribute to it. AIM To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing factors. METHODS A retrospective analysis was conducted using clinical data obtained from questionnaire surveys, interviews, and the medical records of older patients with leukemia admitted to the Hengyang Medical School from June 2020 to June 2023. The data obtained included participants' basic demographic information, medical history, leukemia type, family history of leukemia, average monthly family income, pension, and tendency to conceal illness. The Chinese versions of the Social Impact Scale (SIS), Perceived Social Support Scale (PSSS), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS) were used to assess indicators related to stigma, social support, and mental health status. We used Pearson's correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale, and regression analysis to explore the factors related to the stigma of older patients with leukemia after diagnosis. RESULTS Data from 120 patients with leukemia aged 65-80 years were analyzed. The total score on the SIS and PSSS was 43.60 ± 4.07 and 37.06 ± 2.87, respectively. The SAS score was 58.35 ± 8.32 and the SDS score was 60.58 ± 5.97. The stigma experienced by older leukemia patients was negatively correlated with social support (r = -0.691, P < 0.05) and positively correlated with anxiety and depression (r = 0.506, 0.382, P < 0.05). Age, education level, smoking status, average monthly family income, pension, and tendency to conceal illness were significantly associated with the participants' level of stigma (P < 0.05). Age, smoking status, social support, anxiety, and depression were predictive factors of stigmatization among older leukemia patients after diagnosis (all P < 0.05), with a coefficient of determination (R2) of 0.644 and an adjusted R2 of 0.607. CONCLUSION Older patients commonly experience stigmatization after being diagnosed with leukemia. Factors such as age, smoking status, social support, and psychological well-being may influence older patients' reported experience of stigma.
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Affiliation(s)
- Xuan Tang
- Department of Neurology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
| | - Shuang-Qin Chen
- Department of Neurology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
| | - Jiang-Hua Huang
- Department of Neurology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
| | - Cai-Feng Deng
- Department of Neurology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
| | - Jie-Qiong Zou
- Department of Neurology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
| | - Juan Zuo
- Department of Hematology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
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Ji Q, Zhang L, Xu J, Ji P, Song M, Chen Y, Guo L. The relationship between stigma and quality of life in hospitalized middle-aged and elderly patients with chronic diseases: the mediating role of depression and the moderating role of psychological resilience. Front Psychiatry 2024; 15:1346881. [PMID: 38840950 PMCID: PMC11151782 DOI: 10.3389/fpsyt.2024.1346881] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Accepted: 05/01/2024] [Indexed: 06/07/2024] Open
Abstract
Objective Patients with chronic diseases may have some psychological problems due to their own or surrounding environmental factors, which can adversely affect the patient's illness and life. Given that the number of chronically ill patients in China is currently increasing every year, more research is needed to determine the best ways to manage changes in psychological status and psychological stress responses in chronically ill patients. The researchers constructed a mediated moderation model to explore the impact of stigma on the quality of life of chronically ill patients, as well as the mediating role of depression and the moderating role of psychological resilience. Methods A stratified sampling method was used to select 363 middle-aged and old-aged patients with chronic diseases aged 45 years and older from the Affiliated Hospital of Zhejiang University for the study. Data were collected from patients with chronic diseases such as cardiac, respiratory, renal, and other chronic diseases using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G), the Stigma Scale for Patients with Chronic Diseases (SSCI), the Patient Health Questionaire-9 (PHQ-9), the Quality of Life Inventory (SF-12), and the Conner-Davidson Resilience Scale (CD-RISC) were collected from patients with cardiac, respiratory, renal, and other chronic diseases. A descriptive analysis was used to describe the sample. Linear regression was used to evaluate the relationship between the variables. Mediation and moderation analyses were used to explore the mediating role of depression and the moderating role of psychological resilience. Results There was a moderate negative correlation between stigma and quality of life (r = -0.378, P < 0.01). There was a moderate negative correlation between depression and quality of life (r = -0.497, P < 0.01). There was a moderately positive correlation between psychological resilience and quality of life (r = 0.382, P < 0.01). There was a moderate negative correlation between psychological resilience and depression (r = -0.348, P < 0.01). There was a weak negative correlation between psychological resilience and stigma (r = -0.166, P < 0.01). There was a strong positive correlation between stigma and depression (r = 0.607, P < 0.01) The mediation study showed that stigma was a significant predictor of quality of life and that stigma and quality of life were mediated to some extent by depression, with the mediating effect accounting for 67.55% of the total effect. The direct path from stigma to depression is moderated by psychological resilience (β = -0.0018, P < 0.01). Conclusions Depression mediates the relationship between stigma and quality of life, while psychological elasticity plays a moderating role between stigma and depression, and when the level of psychological elasticity increases, the more significant the role of stigma on depression. As a physiologically and psychologically vulnerable group, patients with chronic diseases' overall quality of life and mental health should be taken more seriously, and clinical workers should pay timely attention to the psychological and mental conditions of patients with chronic diseases and provide timely and appropriate interventions and therapeutic measures. The relevant results of this study also provide a new perspective for clinical work on psychological intervention for patients with chronic diseases.
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Affiliation(s)
- Qiqi Ji
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
| | - Lin Zhang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, Wuhu, An Hui, China
| | - Jiashuang Xu
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
| | - Pengjuan Ji
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
| | - Miaojing Song
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
| | - Yian Chen
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
| | - Leilei Guo
- School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, China
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Xu J, Gu Q, Lu H, Fan J, Ye W. Personality and psychological profile for patients with and without halitosis: A case-control study. Oral Dis 2024; 30:1724-1732. [PMID: 36975762 DOI: 10.1111/odi.14577] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/03/2022] [Revised: 02/23/2023] [Accepted: 03/25/2023] [Indexed: 03/29/2023]
Abstract
OBJECTIVE To compare the personalities, social avoidance and distress, and anxiety status of Chinese patients with and without objective halitosis, and investigate the association among these psychological disorders. METHODS Patients who complained of bad breath and diagnosed with objective halitosis were enrolled into the halitosis group, while patients without objective halitosis were enrolled into the control group. The questionnaires included the sociodemographic profile of the participants, Eysenck Personality Questionnaire (EPQ), Social Avoidance and Distress Scale (SAD), and Beck Anxiety Inventory (BAI). RESULTS A total of 280 patients were assigned into objective halitosis group (n = 146) and control group (n = 134). The extraversion subscales (E) score of the EPQ in the halitosis group were significantly lower than that in the control group (p = 0.001). The total SAD score and proportion of patients with anxiety symptoms in the BAI scale in the objective halitosis was significantly higher than that in the control group (p < 0.05). There was a negative correlation between the extraversion subscale and the total SAD score, Social Avoidance and Social Distress subscales (p < 0.001). CONCLUSION Patients with objective halitosis have more introverted personality traits and are more likely to have social avoidance and distress than the nonhalitosis population.
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Affiliation(s)
- Jing Xu
- Department of Preventive Dentistry, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, China
| | - Qin Gu
- Department of Preventive Dentistry, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, China
| | - Haixia Lu
- Department of Preventive Dentistry, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, China
| | - Juan Fan
- Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, China
| | - Wei Ye
- Department of Preventive Dentistry, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, 639 Zhizaoju Road, Shanghai, China
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Zhang Y, Liu M, Han J, Tian X, Xin Y. Beyond the Burden: A Qualitative Inquiry into the Experiences of Chinese Informal Caregivers for People Living with HIV or AIDS. Patient Prefer Adherence 2024; 18:677-685. [PMID: 38505188 PMCID: PMC10949991 DOI: 10.2147/ppa.s454590] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/12/2023] [Accepted: 03/11/2024] [Indexed: 03/21/2024] Open
Abstract
Purpose Informal caregivers are defined as families or close friends of patients, which take considerable responsibilities for providing care to people living with HIV/AIDS (PLWHA). Although there have been a number of studies in caregiver of PLWHA, research studies that sought to quantify the effects of informal caregiving for the caregivers failed to successfully provide empirical understanding of the nature of caregiving experience. Therefore, this study adopted a qualitative approach to explore the experiences and feelings of caregivers of PLWHA during the long-term care process. Methods The qualitative study was conducted in August 2023 in Beijing, China. Data were collected through individual in-depth semi-structured interviews with informal caregivers of PLWHA. Theme analysis was used to identify themes from the interview transcripts. Results A total of 21 participants were recruited into our study, 16 were family members of PLWAHA, and 5 were homosexual lover or close friend of PLWHA. Three major themes and ten sub themes were identified by thematic analysis: (1) care burden experience (including 5 sub-themes: negative emotional experience, psychological burden, economic burden, physical health loss and limitation of social interaction); (2) benefit findings from care (including 3 sub-theme: positive emotional experience, perceived social support, health promotion); (3) Demands for caregiving capacity (including 2 sub-theme: inadequate caregiving capacity and inadequate psychological comfort capacity). Conclusion This qualitative study provides a comprehensive exploration of the experiences faced by informal caregivers of PLWHA in China, uncovering the complex spectrum of psychological, physical, social, and economic challenges inherent in their caregiving roles, while predominantly challenging, caregivers also reported personal growth, increased social support, and emotional fulfillment. The research results could help in developing effective interventions to reduce the caregiver burden and improve their mental health.
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Affiliation(s)
- Ying Zhang
- School of Public Health, Capital Medical University, Beijing, 100069, People’s Republic of China
| | - Mingyuan Liu
- Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China
| | - Jing Han
- Department of Beijing Home of Red Ribbon, Beijing Ditan Hospital, Capital Medical University, Beijing, 100102, People’s Republic of China
| | - Xin Tian
- Administrative office of hospital, Beijing Ditan Hospital, Capital Medical University, Beijing, 100102, People’s Republic of China
| | - Youqing Xin
- Administrative Office of Hospital, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China
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Zou M, Liu B, Ji J, Ren L, Wang X, Li F. The Relationship Between Negative Coping Styles, Psychological Resilience, and Positive Coping Styles in Military Personnel: A Cross-Lagged Analysis. Psychol Res Behav Manag 2024; 17:13-21. [PMID: 38192275 PMCID: PMC10771775 DOI: 10.2147/prbm.s447096] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2023] [Accepted: 12/20/2023] [Indexed: 01/10/2024] Open
Abstract
Background Military personnel experience prolonged exposure to high-stress environments. Positive coping styles can assist in maintaining their mental and behavioral well-being, whereas negative coping styles cannot. Health behavior change theory specifies that an individual can transition from a negative to a positive coping style. The psychological resilience concept may prove vital in this transition. Methods In a longitudinal study design, two questionnaires were administered to 233 military personnel twice, the first at T1 in April 2023 and the second at T2 in July 2023. The questionnaire measured individual negative coping style, positive coping style and psychological resilience. Results The data showed that the negative coping style at T1 negatively predicted the level of psychological resilience at T2 (γ= - 0.26, p < 0.001) and the positive coping style at T2 (γ= - 0.16, p < 0.001). The level of psychological resilience at T1 positively predicted the positive coping style at T2 (γ= 0.22, p < 0.01). Psychological resilience played a mediating role between negative coping style and positive coping style. In addition, there was an interaction between psychological resilience and positive coping style in military personnel at the two time points. Conclusion The negative coping styles that presently exist among military personnel have the potential to diminish their future positive coping styles by lowering their psychological resilience. This highlights the need to focus on the development and training of psychological resilience for military personnel, as it can effectively counteract negative coping styles and promote positive coping styles.
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Affiliation(s)
- Mingxuan Zou
- Public Health School, Shaanxi University of Chinese Medicine, Xianyang, 712046, People’s Republic of China
- Department of Military Medical Psychology, Air Force Medical University, Xi’ an, 710032, People’s Republic of China
| | - Bin Liu
- Department of Military Medical Psychology, Air Force Medical University, Xi’ an, 710032, People’s Republic of China
| | - Jing Ji
- Public Health School, Shaanxi University of Chinese Medicine, Xianyang, 712046, People’s Republic of China
| | - Lei Ren
- Military Psychology Section, Logistics University of PAP, Tianjin, 300309, People’s Republic of China
- Military Mental Health Services & Research Center, Tianjin, 300309, People’s Republic of China
| | - Xiuchao Wang
- Department of Military Medical Psychology, Air Force Medical University, Xi’ an, 710032, People’s Republic of China
| | - Fengzhan Li
- Department of Military Medical Psychology, Air Force Medical University, Xi’ an, 710032, People’s Republic of China
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Tang N, Pei M, Xie L, Liang X, Hu J, Gao Y. Relationship Between Dyadic Coping with Anxiety and Depression in Infertile Couples: Gender Differences and Dyadic Interaction. Psychol Res Behav Manag 2023; 16:4909-4919. [PMID: 38089528 PMCID: PMC10710950 DOI: 10.2147/prbm.s437808] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2023] [Accepted: 10/24/2023] [Indexed: 09/08/2024] Open
Abstract
BACKGROUND This study aims to examine the relationship between anxiety and depression and dyadic coping in infertile couples, exploring gender differences and dyadic interactions in these associations. METHODS A cross-sectional study was conducted involving 288 couples recruited from the First Affiliated Hospital of Lanzhou University between November 2021 and November 2022. The Dyadic Coping Scale, Anxiety Scale, and Depression Scale were utilized to measure dyadic coping, anxiety, and depression, respectively. The Actor-Partner Interdependence Model was used to analyze the actor effect and partner effect. RESULTS Wives exhibited significantly higher anxiety and depression scores compared to husbands (p<0.001). No statistically significant difference was found in dyadic coping between wives and husbands. Positive dyadic coping in infertile couples had significant actor effects on anxiety and depression (p<0.05) and partner effects (p<0.05). Positive dyadic coping negatively predicted anxiety and depression of oneself and one's partner. Negative dyadic coping in infertile couples also had significant actor effects on anxiety and depression (p<0.05) and partner effects (p<0.05). Negative dyadic coping positively predicted anxiety and depression of oneself and one's partner. CONCLUSION The dyadic coping style of infertile couples has both actor and partner effects on their own and their partner's anxiety and depression. Anxiety and depression in infertile couples are influenced by their own and their partner's dyadic coping style, respectively. Therefore, dyadic coping serves as an important indicator for predicting psychological outcomes in these couples.
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Affiliation(s)
- Nan Tang
- Department of Nursing, 1th Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
- School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
| | - Mengyue Pei
- School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
- Henan Kaifeng College of Science Technology and Communication, Kaifei, Henan, People’s Republic of China
| | - Lei Xie
- School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
- Renji Hospital, Shanghai Jiaotong University, Shanghai, People’s Republic of China
| | - Xueping Liang
- School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
| | - Junping Hu
- School of Nursing, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
- The First hospital of Lanzhou University, Lanzhou, Gansu, People’s Republic of China
| | - Yuan Gao
- Department of Nursing, 1th Medical Centre of PLA General Hospital, Beijing, People’s Republic of China
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11
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Wang G, Liu X, Zhu S, Lei J. Experience of mental health in women with Polycystic Ovary Syndrome: a descriptive phenomenological study. J Psychosom Obstet Gynaecol 2023; 44:2218987. [PMID: 37267127 DOI: 10.1080/0167482x.2023.2218987] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/12/2023] [Revised: 05/18/2023] [Accepted: 05/23/2023] [Indexed: 06/04/2023] Open
Abstract
Purpose: This study aims to investigate the experiences, emotional coping strategies, and help-seeking needs of women with PCOS from their perspective, considering common psychological issues such as stress, anxiety, and depression that are prevalent among individuals with PCOS. Materials and Methods: The study recruited 14 women with PCOS for semi-structured interviews between October and November 2022, using a descriptive phenomenology method design. The interviews were analyzed using NVivo 12 software. Results: Four themes and eleven subthemes were derived from the semi-structured interviews: (1) Negative Mental Health Status; (2) Four Patterns of Emotion Regulation; (3) The Psychological Double-Edged Sword: Family Social Network; (4) Strong Demands for Psychological Counseling and Lifestyle Guidance. Conclusion: The study suggests that interventions should focus on fostering internalized self-efficacy and emotional expression, promoting constructive familial support, and providing psychological counseling and lifestyle recommendations to alleviate psychological distress experienced by women with PCOS.
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Affiliation(s)
- Guangpeng Wang
- The Third Xiangya Hospital of Central South University, Changsha, China
- Xiangya School of Nursing, Central South University, Changsha, China
| | - Xueyan Liu
- School of Nursing, Shandong University, Jinan, China
| | - Shujuan Zhu
- The Third Xiangya Hospital of Central South University, Changsha, China
| | - Jun Lei
- The Third Xiangya Hospital of Central South University, Changsha, China
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12
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Xie Y, Ren Y, Niu C, Zheng Y, Yu P, Li L. The impact of stigma on mental health and quality of life of infertile women: A systematic review. Front Psychol 2023; 13:1093459. [PMID: 36698573 PMCID: PMC9869765 DOI: 10.3389/fpsyg.2022.1093459] [Citation(s) in RCA: 12] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2022] [Accepted: 11/30/2022] [Indexed: 01/11/2023] Open
Abstract
Introduction The stigma of not giving birth to children affects approximately 53. 08~64% of female infertility patients worldwide. This stigma not only causes harm to the mental health of these infertility patients, but also affects their quality of life, making them bear the adverse social consequences such as domestic violence, marriage breakdown, or even delay in receiving the treatment. Therefore, it is crucial to have a deep understanding of the patients' stigma and effective intervention in alleviating it. Aims/Question This study aims to discuss and summarize the stigma in infertile women and its impact on patients, and to provide a theoretical basis for the clinical treatment and nursing intervention of disease stigma in infertile female patients. Methods The literature search used four English databases (Cochrane Library, EMBASE, Web of Science, and PubMed) and two Chinese databases (CNKI and Wanfang). The search time of the literature ranges from the establishment of the library to 2022, with no language restriction. Results The review included 28 studies, with 20 cross-sectional studies and 8 qualitative studies. This study found that social support, living environment, education level, occupation, and fertility awareness were the major influencing factors of infertility stigma. Conclusions Infertility stigma can bring heavy mental pressure and psychological burden to female infertility patients and affect their quality of life. Therefore, effective and targeted psychological interventions should be developed to reduce the patients' stigma and improve their quality of life. Implications for practice Healthcare workers must develop targeted nursing interventions, provide professional counseling services to reduce the level of stigma in female infertility patients, alleviate fertility stress, and improve their quality of life.
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Affiliation(s)
- Yue Xie
- School of Nursing and Public Health, Yangzhou University, Yangzhou, China
| | - Yue Ren
- School of Nursing and Public Health, Yangzhou University, Yangzhou, China
| | - Changmin Niu
- School of Nursing and Public Health, Yangzhou University, Yangzhou, China
| | - Ying Zheng
- School of Nursing and Public Health, Yangzhou University, Yangzhou, China
| | - Ping Yu
- Affiliated Hospital of Yangzhou University, Yangzhou, China
| | - Lin Li
- Affiliated Hospital of Yangzhou University, Yangzhou, China
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13
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Zhang X, Yang L, Wang W, Yang L. Psychological distress, emotion regulation, neuroticism, and sexual relationship on patients with temporary ejaculation failure in vitro fertilization-embryo transfer treatment. Front Psychol 2023; 13:1090244. [PMID: 36687954 PMCID: PMC9853009 DOI: 10.3389/fpsyg.2022.1090244] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2022] [Accepted: 12/16/2022] [Indexed: 01/09/2023] Open
Abstract
Objective Temporary ejaculation failure on the oocyte retrieval day might leading interruption of the oocyte retrieval procedure. The present study aims to understand the psychosocial factor that affects men with temporary ejaculation failure (TEF) in Vitro fertilization-embryo transfer (IVF-ET) patients, and thus provide new ideas for optimal clinical treatment. Study design In a prospective study, the male patients during IVF treatment in a reproductive center of a tertiary hospital in Shandong were divided into two groups, 70 men with TEF and 79 normal controls. General population sociology and clinical disease were investigated, and the Kessler 10 scale, emotion regulation questionnaire, big five inventory questionnaire, and sex subscale of marriage quality were used to assess the psychological distress, emotion regulation, neuroticism, and satisfaction with sexual life. Results The scores of perceived distress and neuroticism of the TEF group were higher than the non-TEF group (p < 0.001), and cognitive reappraisal and sexual relationship were significantly lower than those in the non-TEF group (p < 0.001). Psychological distress (OR 1.130, p = 0.031) and neuroticism (OR 1.096, p = 0.050) were risk factors for TEF, while cognitive reappraisal (OR 0.883, p = 0.004) and sexual relationship (OR 0.712, p < 0.001) was protective factors. Conclusion The present study demonstrates that psychosocial factors influence TEF in IVF-ET patients, which provides the basis for the prevention of the occurrence of TEF in a male undergoing IVF-ET.
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Affiliation(s)
- Xinting Zhang
- Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China
| | - Lexia Yang
- Nursing Department, The Third Hospital of Jinan, Jinan, China
| | - Wei Wang
- Department of Psychology, Qilu Hospital of Shandong University, Jinan, China,*Correspondence: Wei Wang, ✉
| | - Lejin Yang
- Department of Psychology, Qilu Hospital of Shandong University, Jinan, China,Lejin Yang, ✉
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14
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Wang L, Tang Y, Wang Y. Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study. PLoS One 2023; 18:e0284414. [PMID: 37053254 PMCID: PMC10101516 DOI: 10.1371/journal.pone.0284414] [Citation(s) in RCA: 9] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2023] [Accepted: 03/30/2023] [Indexed: 04/14/2023] Open
Abstract
The global incidence of infertility is increasing year by year, and the association between infertility and mental illness has been widely concerned. The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might lead to anxiety and depression. From January 2020 to December 2020, female infertile patients who received assisted reproduction technology (ART) treatment at West China Second Hospital were recruited and a total of 1712 eligible female patients were finally enrolled in this study. Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionaire-9 (PHQ-9) were used to evaluate the patients' psychological status. The reliability of all scales was evaluated by Cronbach's α and Spearman-Brown half coefficient, and Kaiser-Meyer-Olkin (KMO) value was calculated by factor analysis to evaluate validity. Univariate and multivariate logistic regression analysis were applied for assessing independent risk factors of anxiety and depression, respectively. The incidence of anxiety and depression in infertile women were 25.2% and 31.3%, respectively. Cronbach's α coefficients and Spearman-Brown half-fold coefficients of GAD-7 and PHQ-9 were 0.870, 0.825, 0.852 and 0.793, respectively. Univariate and multivariate logistic regression analysis showed that education level (junior college degree or above, OR:1. 6, 95% CI: 1.2-2.1, P = 0.003), somatic symptoms (severe somatic symptoms, OR:15.2, 95%CI: 5.6-41.3, P<0.001), sleep quality (poor sleep quality, OR:9.3, 95% CI:4.7-18.4, P<0.001) were independent risk factors for anxiety. And age>35 years old, moderate and severe somatic symptoms and poor sleep quality were independent risk factors for depression. Somatic symptoms and poor sleep quality are both the risk factors of anxiety and depression symptoms of infertile woman. And high educated (junior college degree or above) patients are more likely to be complicated with anxiety symptoms, while elderly patients (age>35) are prone to be complicated with depression symptoms.
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Affiliation(s)
- Lingyan Wang
- Department of Obstetrics and Gynecology Nursing, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Sichuan University, Chengdu P.R. China
| | - Youyin Tang
- Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China
| | - Yuyang Wang
- Department of Obstetrics and Gynecology Nursing, Key Laboratory of Birth Defects and Related Disease of Women and Children, West China Second University Hospital, Sichuan University, Chengdu P.R. China
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15
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Zhang D, Lyu B, Wu J, Li W, Zhang K. Effect of boxers' social support on mental fatigue: Chain mediating effects of coach leadership behaviors and psychological resilience. Work 2023; 76:1465-1479. [PMID: 37807793 DOI: 10.3233/wor-220478] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/10/2023] Open
Abstract
BACKGROUND Athletic fatigue is an inescapable issue in competitive sports. It belongs to a physiological response that is triggered when competitive athletes are trained to a critical point. OBJECTIVE The study aims to explore the relationships involving boxers' social support, mental fatigue, coach leadership behaviors and psychological resilience. METHODS 1050 boxers were selected in several provinces across China and investigated on the basis of the Social Support Questionnaire for Athletes, Mental Fatigue Scale, Psychological Resilience Scale, and Leadership Scale for Sport. RESULTS Boxers' social support was negatively correlated with mental fatigue and psychological resilience, while it was positively correlated with coach leadership behaviors. Apart from direct effects on mental fatigue, other impacts are imposed by boxers' social support via mediating effects such as coach leadership behaviors and psychological resilience. The total effect value was -0.18, the direct effect value was -0.08, and the indirect effect value was -0.12; furthermore, coach leadership behaviors and psychological resilience play a mediating role, accounting for 65.57% of the total. CONCLUSION In order to alleviate the stress from intense competitive training and abate mental fatigue, competitive athletes may be encouraged in subsequent training to seek all-sided social support for social interpersonal relationships. While clarifying the mechanism how the external environment affects individuals, this paper explains the principle of social support on athletes' psychological fatigue and identifies mutual influences between coaches and athletes.
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Affiliation(s)
- Defa Zhang
- Department of Physical Education, Suzhou University, Suzhou, China
| | - Bei Lyu
- School of Economics and Management, Huaibei Normal University, Huaibei, China
- Chinese Graduate School, Panyapiwat Institute of Management, Nonthaburi, Thailand
| | - Jingtao Wu
- Tibetan-Qiang-Yi Corridor Physical Health Promotion Research Center, Leshan Normal University, Leshan, China
| | - Wangze Li
- School of Materials, North China University of Science and Technology, Tangshan, China
| | - Kaiyuan Zhang
- Department of Physical Education, Suzhou University, Suzhou, China
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Yokota R, Okuhara T, Okada H, Goto E, Sakakibara K, Kiuchi T. Associations between Stigma, Cognitive Appraisals, Coping Strategies and Stress Responses among Japanese Women Undergoing Infertility Treatment. Healthcare (Basel) 2022; 10:1907. [PMID: 36292354 PMCID: PMC9601508 DOI: 10.3390/healthcare10101907] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2022] [Revised: 09/22/2022] [Accepted: 09/27/2022] [Indexed: 11/20/2022] Open
Abstract
The number of infertility treatment cycles in Japan is the highest worldwide. Studies have shown that stigma is a predictor of stress-related symptoms including anxiety and depression in women undergoing infertility treatment. Stress management to prevent stress-related symptoms may be crucial; however, few studies have examined the model of stigma and stress responses. Based on the stress-coping model, we hypothesized that stigma threatens the identity of such women and that coping failure increases stress responses. We aimed to explore the role of cognitive appraisals and coping strategies as mediators of the association between the stigma of infertility and stress responses. In December 2021, we conducted a cross-sectional study in Japan, in which 254 women undergoing infertility treatment completed a web-based survey. Hierarchical multiple regression analysis was conducted to analyze the associations between stigma, cognitive appraisals, coping strategies, and stress responses. The results showed that explanatory power increased with each additional variable in the following order: stigma, cognitive appraisals, and coping. Participants with a high level of stigma evaluated it as threatening, and used self-blame and venting coping strategies, and showed higher stress responses. Conversely, participants who used positive reframing coping strategies exhibited lower stress responses. Based on this, effective strategies to address stigma and stress responses are necessitated.
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Affiliation(s)
- Rie Yokota
- Department of Health Communication, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
| | - Tsuyoshi Okuhara
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan
| | - Hiroko Okada
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan
| | - Eiko Goto
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan
| | - Keiko Sakakibara
- Department of Social Psychology, Faculty of Sociology, Toyo University, Tokyo 112-8606, Japan
| | - Takahiro Kiuchi
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan
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Whole-Genome Profile of Greek Patients with Teratozοοspermia: Identification of Candidate Variants and Genes. Genes (Basel) 2022; 13:genes13091606. [PMID: 36140773 PMCID: PMC9498395 DOI: 10.3390/genes13091606] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2022] [Revised: 08/23/2022] [Accepted: 08/30/2022] [Indexed: 01/09/2023] Open
Abstract
Male infertility is a global health problem that affects a large number of couples worldwide. It can be categorized into specific subtypes, including teratozoospermia. The present study aimed to identify new variants associated with teratozoospermia in the Greek population and to explore the role of genes on which these were identified. For this reason, whole-genome sequencing (WGS) was performed on normozoospermic and teratozoospermic individuals, and after selecting only variants found in teratozoospermic men, these were further prioritized using a wide range of tools, functional and predictive algorithms, etc. An average of 600,000 variants were identified, and of them, 61 were characterized as high impact and 153 as moderate impact. Many of these are mapped in genes previously associated with male infertility, yet others are related for the first time to teratozoospermia. Furthermore, pathway enrichment analysis and Gene ontology (GO) analyses revealed the important role of the extracellular matrix in teratozoospermia. Therefore, the present study confirms the contribution of genes studied in the past to male infertility and sheds light on new molecular mechanisms by providing a list of variants and candidate genes associated with teratozoospermia in the Greek population.
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Arsalan M, Haider A, Cho SW, Kim YH, Park KR. Human Blastocyst Components Detection Using Multiscale Aggregation Semantic Segmentation Network for Embryonic Analysis. Biomedicines 2022; 10:biomedicines10071717. [PMID: 35885022 PMCID: PMC9313331 DOI: 10.3390/biomedicines10071717] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2022] [Revised: 07/08/2022] [Accepted: 07/13/2022] [Indexed: 11/16/2022] Open
Abstract
Infertility is one of the most important health concerns worldwide. It is characterized by not being successful of pregnancy after some periods of periodic unprotected sexual intercourse. In vitro fertilization (IVF) is an assisted reproduction technique that efficiently addresses infertility. IVF replaces the actual mode of reproduction through a manual procedure wherein embryos are cultivated in a controlled laboratory environment until they reach the blastocyst stage. The standard IVF procedure includes the transfer of one or two blastocysts from several blastocysts that are grown in a controlled environment. The morphometric properties of blastocysts with their compartments such as trophectoderm (TE), zona pellucida (ZP), inner cell mass (ICM), and blastocoel (BL), are analyzed through manual microscopic analysis to predict viability. Deep learning has been extensively used for medical diagnosis and analysis and can be a powerful tool to automate the morphological analysis of human blastocysts. However, the existing approaches are inaccurate and require extensive preprocessing and expensive architectures. Thus, to cope with the automatic detection of blastocyst components, this study proposed a novel multiscale aggregation semantic segmentation network (MASS-Net) that combined four different scales via depth-wise concatenation. The extensive use of depthwise separable convolutions resulted in a decrease in the number of trainable parameters. Further, the innovative multiscale design provided rich spatial information of different resolutions, thereby achieving good segmentation performance without a very deep architecture. MASS-Net utilized 2.06 million trainable parameters and accurately detects TE, ZP, ICM, and BL without using preprocessing stages. Moreover, it can provide a separate binary mask for each blastocyst component simultaneously, and these masks provide the structure of each component for embryonic analysis. Further, the proposed MASS-Net was evaluated using publicly available human blastocyst (microscopic) imaging data. The experimental results revealed that it can effectively detect TE, ZP, ICM, and BL with mean Jaccard indices of 79.08, 84.69, 85.88%, and 89.28%, respectively, for embryological analysis, which was higher than those of the state-of-the-art methods.
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Yokota R, Okuhara T, Okada H, Goto E, Sakakibara K, Kiuchi T. Association between Stigma and Anxiety, Depression, and Psychological Distress among Japanese Women Undergoing Infertility Treatment. Healthcare (Basel) 2022; 10:1300. [PMID: 35885826 PMCID: PMC9325025 DOI: 10.3390/healthcare10071300] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/26/2022] [Revised: 07/11/2022] [Accepted: 07/12/2022] [Indexed: 01/05/2023] Open
Abstract
Japan has the highest number of cases of infertility treatment in the world. Studies have indicated that women undergoing infertility treatment feel stigmatized and suffer from psychological symptoms such as anxiety and depression. However, in Japan, few studies have quantitatively examined the association between the stigma of infertility and psychological symptoms, and, to our knowledge, no study has examined its association using a scale with tested reliability and validity. This study aims to quantitatively examine the relationship between infertility stigma and anxiety, depression, and psychological distress among women undergoing infertility treatment, using a scale that has been validated for reliability and validity. The cross-sectional study was conducted in December 2021 through a web-based survey of 254 participants undergoing infertility treatment. A multiple regression analysis was performed to examine the relationship between stigma and anxiety, depression, and psychological distress. Stigma was a statistically significant predictor of anxiety, depression, and psychological distress (standardized β = 0.58, p < 0.001; β = 0.50, p < 0.001; β = 0.62, p < 0.001, respectively) after controlling for sociodemographic and infertility characteristics. Future studies should examine the causal relationship between stigma and anxiety, depression, and psychological distress and how to intervene to reduce stigma among women undergoing infertility treatment.
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Affiliation(s)
- Rie Yokota
- Department of Health Communication, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
| | - Tsuyoshi Okuhara
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan; (T.O.); (H.O.); (E.G.); (T.K.)
| | - Hiroko Okada
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan; (T.O.); (H.O.); (E.G.); (T.K.)
| | - Eiko Goto
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan; (T.O.); (H.O.); (E.G.); (T.K.)
| | - Keiko Sakakibara
- Department of Social Psychology, Faculty of Sociology, Toyo University, Tokyo 112-8606, Japan;
| | - Takahiro Kiuchi
- Department of Health Communication, School of Public Health, The University of Tokyo, Tokyo 113-8655, Japan; (T.O.); (H.O.); (E.G.); (T.K.)
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