This systematic review aimed to evaluate and synthesize the scientific evidence of virtual reality (VR) interventions on quality of life, cognitive function, and physical function in older people with Alzheimer's disease (AD). A systematic review search until March 2025 using seven generic databases: PubMed, EBSCOhost, CINAHL Complete, Cochrane, ProQuest, Scopus, and Web of Science. The PRISMA, RoB 2, and GRADEpro tools were used to assess the methodological quality, risk of bias, and certainty of the evidence.The protocol was registered in PROSPERO database, CRD42024629853. Of 3347 records identified across the databases, seven studies were analyzed using the PICOS format. This review included 517 older people with AD (mean age 76.5 years; 57.5 % female). Due to the heterogeneity of the assessment tools, a meta-analysis could not be performed. Although no consistent significant differences were found between the experimental and control groups, several individual studies reported improvements. Specifically, two studies showed improvements in quality of life and cognitive function, while three reported enhancements in physical function. The interventions included immersive cognitive training, exergaming, Kinect-based systems, and Physiomat platforms, with durations ranging from 4 to 16 weeks and frequencies of 2-5 sessions per week. Analysis of the reviewed studies suggests that VR interventions may benefit cognitive function, physical function, and, to a lesser extent, quality of life in older people with AD.

Dual-task training (DTT) positively impacts stroke recovery, but its effects on electroencephalography (EEG) using Fourier series analysis are under-researched. This study aimed to evaluate the effects of DTT on EEG in stroke patients by analyzing different EEG bands with fast Fourier transform (FFT).

Five participants with unilateral ischemic stroke completed 12 sessions of 15-min DTT, three times a week for 4 weeks. EEG data were recorded before and after the intervention, and FFT analysis was conducted. Assessments of upper limb function, elbow flexor muscle tone, and daily living activities were also performed.

FFT analysis showed a reduction in delta, theta, alpha, and beta bands post-DTT, while their correlation between measurement times remained consistent. These changes were somewhat reflected in the participants' improved clinical outcomes.

The results suggest that DTT positively affects EEG band frequencies, with a consistent correlation between pre- and post-intervention measurements. This indicates that FFT analysis could be a useful tool for assessing DTT's impact on stroke recovery.

Cognitive training for older adults is crucial before cognitive impairment emerges. During periods of social distancing like the COVID-19 pandemic, cognitive stimuli are lacking. Online dual-task training is proposed as a solution to address these needs.

We aimed to explore the feasibility, acceptance, and potential effects of online group-based dual-task training as an intervention for enhancing cognitive function among community-dwelling older adults.

A randomized controlled feasibility study was conducted with 76 participants in Hong Kong, randomly assigned to the intervention and attention control groups in a ratio of 2:1 (n=50, 66% and n=26, 34%, respectively). The intervention group underwent 60-minute online dual-task training sessions twice a week for 12 weeks, incorporating cognitive components (upper limb and finger movement, arithmetic operation, and verbal fluency) and physical components (chair-based exercises) developed through a co-design approach. The attention control group received online health talks. Outcomes related to feasibility and acceptance included class attendance and self-reported satisfaction. Main outcomes related to potential effects included the Memory Inventory in Chinese and the Montreal Cognitive Assessment 5 Minutes (Hong Kong Version) at baseline, 6 weeks (midintervention), 12 weeks (postintervention) and 18 weeks (follow-up). Descriptive statistics and linear mixed effects models were used. Effect size was described with Cohen d. Qualitative feedback was collected from 12 informants and analyzed by thematic analysis.

About 72% (36/50) of the participants in the intervention group and 62% (16/26) in the control group attended over 75% of the classes. In total, 44 (88%) participants from the intervention group provided acceptance feedback; 82% (36/44) were satisfied and 84% (37/44) would recommend the training to others. Improvement in the Memory Inventory in Chinese score in the intervention group was observed at midintervention, postintervention, and follow-up, with a medium-to-large effect size (d=0.65, 0.43 and 0.85, respectively). Adjusting for baseline values, the between-group differences in the Montreal Cognitive Assessment 5 Minutes (Hong Kong Version) score attained a small-to-medium effect size at midintervention (d=0.34) and postintervention (d=0.23). Qualitative feedback highlighted the timesaving and convenient aspects of online dual-task training, with participants finding the sessions challenging and enjoyable, and reporting benefits across cognitive, physical, and psychosocial domains. However, a preference for traditional in-person training was noted among the older adults despite the advantages of online training.

Online dual-task training is a feasible intervention accepted by the older adults, with potential benefits in cognitive abilities. Online training may complement in-person sessions. Further investigation in a full-scale randomized controlled trial is warranted to comprehensively explore its effects and address areas for improvement.

ClinicalTrials.gov NCT05573646; https://clinicaltrials.gov/study/NCT05573646.

The causal relationship between slow gait speed and poor cognition is uncertain due to potential reverse causality. This study aimed to examine the reciprocal relationship between gait speed and global as well as domain-specific cognitive functions in older adults.

Prospective cohort study (2013-2022) including 4 repeated measures.

Community-dwelling and adults without dementia aged ≥65 recruited at baseline.

Biennial evaluations included assessments of 4-m usual walking speed, global cognition using the Taiwanese version of the Montreal Cognitive Assessment (MoCA), and cognitive domains (memory, executive function, verbal fluency, and attention) using a battery of neuropsychological tests. Cross-lagged models and linear mixed models were used to examine the bidirectional association between gait speed and cognitive functions with adjustment for potential confounders.

At baseline, 511 participants were enrolled, and 459 individuals with a mean age of 74.5 years were ultimately analyzed. A 1-SD decrease in gait speed was associated with a 0.07-0.09 SD decrease in subsequent global cognition [βˆWave 1→2: 0.07, standard error (SE): 0.03; βˆWave 2→3: 0.09, SE: 0.04; βˆWave 3→4: 0.09, SE: 0.04; all P < .05]. Similarly, a 1-SD decrease in global cognition was associated with a 0.18 to 0.19 SD decrease in subsequent gait speed (βˆWave 1→2: 0.18, SE: 0.05; βˆWave 2→3: 0.18, SE: 0.06; βˆWave 3→4: 0.19, SE: 0.07; all P < .001). In addition, slower gait speed was associated with poor memory, verbal fluency, and executive function, and vice versa. The results of linear mixed models were consistent with the findings obtained from cross-lagged models.

This study found a reciprocal association between gait speed and global or domain-specific cognition. Regularly screening gait speed and cognitive function enables the early detection of declines in physical function and cognition.

To evaluate and compare the effects of different dual task interventions on cognitive function in older adults with cognitive impairment or dementia.

We searched eight databases, including PubMed, Cochrane Library, and EMBASE, to obtain studies exclusively comprising randomized controlled trials on dual task interventions in individuals aged 60 and older with mild cognitive impairment or dementia, up to July 28, 2024. Study quality was evaluated using the Cochrane Risk of Bias Tool. Analyses included pairwise meta-analyses via Review Manager 5.4 and network meta-analyses via Stata 14.0.

A total of 32 RCTs involving 2370 participants were included. Dual cognitive task training had the most significant impact on global cognition (SUCRA = 79.2%, mean rank = 1.6) and motor-cognitive dual task training was the only dual task intervention with a notable improvement in executive function (SMD = 1.53, 95% CI 0.06-3.01). For physical function, dual motor task training was most effective, improving gait performance (SMD = 0.34), muscle strength (SMD = 0.28), and balance (SMD = 0.90). Motor-cognitive dual task training demonstrated the greatest effectiveness in enhancing activities of daily living (SMD = 1.50) and quality of life (SMD = 1.20), while reducing depressive symptoms (SMD = - 0.96).

Dual cognitive task training is the most effective dual task intervention for enhancing global cognition. Motor-cognitive dual task training is the only dual task mode that significantly improves executive cognition.

Cognitive frailty and depression are prevalent among the elderly, significantly impairing physical and cognitive functions, psychological well-being, and quality of life. Effective interventions are essential to mitigate these adverse effects and enhance overall health outcomes in this population.

To evaluate the effects of exercise-cognitive dual-task training on frailty, cognitive function, psychological status, and quality of life in elderly patients with cognitive frailty and depression.

A retrospective study was conducted on 130 patients with cognitive frailty and depression admitted between December 2021 and December 2023. Patients were divided into a control group receiving routine intervention and an observation group undergoing exercise-cognitive dual-task training in addition to routine care. Frailty, cognitive function, balance and gait, psychological status, and quality of life were assessed before and after the intervention.

After the intervention, the frailty score of the observation group was (5.32 ± 0.69), lower than that of the control group (5.71 ± 0.55). The Montreal cognitive assessment basic scale score in the observation group was (24.06 ± 0.99), higher than the control group (23.43 ± 1.40). The performance oriented mobility assessment score in the observation group was (21.81 ± 1.24), higher than the control group (21.15 ± 1.26). The self-efficacy in the observation group was (28.27 ± 2.66), higher than the control group (30.05 ± 2.66). The anxiety score in the hospital anxiety and depression scale (HADS) for the observation group was (5.86 ± 0.68), lower than the control group (6.21 ± 0.64). The depression score in the HADS for the observation group was (5.67 ± 0.75), lower than the control group (6.27 ± 0.92). Additionally, the scores for each dimension of the 36-item short form survey in the observation group were higher than those in the control group, with statistically significant differences (P < 0.05).

Exercise-cognitive dual-task training is beneficial for improving frailty, enhancing cognitive function, and improving psychological status and quality of life in elderly patients with cognitive frailty and depression.

Disability profoundly affects older adults' quality of life and imposes considerable burdens on health care systems in China's aging society. Timely predictive models are essential for early intervention.

We aimed to build effective predictive models of disability for early intervention and management in older adults in China, integrating physical, cognitive, physiological, and psychological factors.

Data from the China Health and Retirement Longitudinal Study (CHARLS), spanning from 2015 to 2020 and involving 2450 older individuals initially in good health, were analyzed. The dataset was randomly divided into a training set with 70% data and a testing set with 30% data. LASSO regression with 10-fold cross-validation identified key predictors, which were then used to develop an Extreme Gradient Boosting (XGBoost) model. Model performance was evaluated using receiever operating characteristic curves, calibration curves, and clinical decision and impact curves. Variable contributions were interpreted using SHapley Additive exPlanations (SHAP) values.

LASSO regression was used to evaluate 36 potential predictors, resulting in a model incorporating 9 key variables: age, hand grip strength, standing balance, the 5-repetition chair stand test (CS-5), pain, depression, cognition, respiratory function, and comorbidities. The XGBoost model demonstrated an area under the curve of 0.846 (95% CI 0.825-0.866) for the training set and 0.698 (95% CI 0.654-0.743) for the testing set. Calibration curves demonstrated reliable predictive accuracy, with mean absolute errors of 0.001 and 0.011 for the training and testing sets, respectively. Clinical decision and impact curves demonstrated significant utility across risk thresholds. SHAP analysis identified pain, respiratory function, and age as top predictors, highlighting their substantial roles in disability risk. Hand grip and the CS-5 also significantly influenced the model. A web-based application was developed for personalized risk assessment and decision-making.

A reliable predictive model for 5-year disability risk in Chinese older adults was developed and validated. This model enables the identification of high-risk individuals, supports early interventions, and optimizes resource allocation. Future efforts will focus on updating the model with new CHARLS data and validating it with external datasets.

Research on executive functions training shows inconsistent outcomes, with factors like age, baseline cognitive abilities, and personality traits implicated as predictive of training gains, while limited attention has been given to neurophysiological markers. Theta and alpha band power are linked to cognitive performance, suggesting a potential area for further study. This study aimed to determine whether relative theta and alpha power and their ratio could predict gains in updating and inhibition training beyond the practice effects (the order of training session). Forty healthy middle-aged adults (aged 49-65) were randomly assigned to either the cognitive training group (n = 20), or the communication skills (control) group (n = 20). Both groups completed the self-administered training sessions twice a week for 10 weeks, totaling to 20 sessions. Resting-state EEG data were recorded before the first session. Mixed-effects model analyses revealed that higher relative parietal alpha power positively predicted training performance, while theta power negatively predicted performance. Additionally, higher parietal alpha/theta ratio was associated with better training outcomes, while the frontal alpha/theta ratio did not demonstrate significant predictive value. Other EEG measures did not show additional predictive power beyond what was accounted for by the session effects. The findings imply that individuals with specific EEG pattern may change with cognitive training, making resting-state EEG a useful tool in tailoring interventions.

There is growing literature examining the effects of balance training on cognitive function in individuals with multiple sclerosis (MS), yet the findings remain inconsistent. This study aimed to investigate methodological characteristics of balance training studies and examine the effects of this modality on cognitive function.

This study performed literature search using MEDLINE, EMBASE, PsycINFO, SPORTSDiscus, and CINAHL databases from inception to April 2024. Randomized and non-randomized controlled trials of balance training studies that assessed cognitive function were included. The Tool for the Assessment of Study Quality and Reporting in Exercise was used to evaluate methodological quality of included studies. We calculated effect sizes as standardized mean differences (SMD) using Hedge's g and employed multi-level random-effects model for meta-analysis.

Fourteen articles with 1,020 participants were included in this review, and a subset of seven studies with 26 effect sizes were further used for meta-analysis. Balance training indicated medium effects on global cognition (SMD [95 % CI] = 0.39 [0.13, 0.64]), processing speed (SMD [95 % CI] = 0.36 [0.00, 0.73]), and visuospatial memory (SMD [95 % CI] = 0.53 [0.12, 0.93]) and large effect on verbal memory (SMD [95 % CI] = 0.66 [0.25, 1.06]). We found that intervention characteristics and exercise doses significantly moderated the effects on cognition.

Balance training may effectively improve overall and specific domains of cognitive function in persons with MS. Exercise doses of at least 120 min per week and a total duration of 720 min or more were significant moderators for greater cognitive improvement.

Functional power-based exercise training can improve physical performance in older adults and cognitive training can improve measures of cognition, but their combined effects on cognition and related risk factors (neurological and inflammatory markers) remains uncertain. This 6-month cluster randomised controlled trial evaluated the effectiveness of dual-task functional power training (DT-FPT) on cognition and circulating neurological and inflammatory markers in older adults at increased falls risk, and whether intervention responses varied by apolipoprotein-E (ApoE) and brain derived neurotrophic factor (BDNF) polymorphisms. Three hundred residents aged ≥ 65 years at increased falls risk residing in 22 independent-living retirement communities, were randomised by village, to DT-FPT (n = 156, 11 villages) involving a multi-component power-based training program performed simultaneously with cognitive and/or motor tasks (45-60 min, 2/week), or a usual care control (CON) group (n = 144, 11 villages). Cognition (computerized CogState battery), inflammatory cytokines, BDNF, insulin-like growth factor-1, vascular endothelial growth factor, amyloid β (1-40) and (1-42) were assessed at baseline and 6-months. Overall, 233 (78%) participants completed the intervention and adherence averaged 50.1%. DT-FPT led to a net 0.18-0.20 SD benefit versus CON in psychomotor ability/attention and reaction time/attention (both P < 0.05). There were no significant intervention effects on circulating markers, except for a net 10.5% benefit in amyloid β (1-40) in DT-FPT versus CON (P < 0.05). Responses were not influenced by APOE or BDNF genotype. In conclusion, DT-FPT in older adults at increased falls risk can provide some cognitive benefits, but these were not related to corresponding changes in inflammatory or neurological markers or influenced by genotype. Australian New Zealand Clinical Trials Registry (ACTRN12613001161718). http://www.anzctr.org.au/ This project was funded by a grant from the National Health and Medical Research Council (NHMRC) Project (APP1046267).

Older adults with cognitive frailty often have impaired dual-task walking and prefrontal cortex (PFC) activation. Combining cycling with interactive boxing offers an innovative and interesting dual-task training to challenge both physical and cognitive skills. This study investigated the effects of interactive boxing-cycling on this population. Thirty-nine participants were assigned to the interactive boxing-cycling group (n = 20) or the stationary cycling group (n = 19) for 36 sessions over 12 weeks. The outcomes included dual-task walking performance, PFC activation, cognitive function, and frailty scores. Results showed the interactive boxing-cycling group had greater improvements in dual-task walking speed and cost and beneficially reduced oxygenated hemoglobin levels compared to the stationary group. Furthermore, both groups improved in frailty and cognition, but the interactive boxing-cycling group had better effects on general and specific cognitive function. Interactive boxing-cycling is an efficient intervention to enhance dual-task walking and PFC activation in older adults with cognitive frailty.

Aging is associated with both cognitive and physical decline. Some factors, such as lifestyle and environment, can significantly contribute to accelerating or slowing down the decline processes. Our study aimed to evaluate the impact of lifestyle (active vs. non-active) and environmental context (institutionalized vs. non-institutionalized) on the cognitive functioning, psychological well-being, sleep quality, and daily living skills of elderly people.

Our sample consisted of 182 subjects divided into active and non-active groups (subjects who engage or not in physical and social activities, respectively; mean age in years: 67.19 vs. 68.75) and 245 subjects divided into institutionalized and non-institutionalized groups (i.e., living in a nursing home or not, respectively; mean age in years: 79.49 vs. 71.72). Participants were enrolled voluntarily and randomly in the city of L'Aquila. A battery of psychological instruments was administered to evaluate general cognitive decline, depressive symptoms, self-assessed sleep quality, and daily living skills.

Regarding lifestyle, the active group exhibited significantly lower levels of depression, better sleep quality, and daily living skills with respect to the non-active group. Regarding environmental context, institutionalized subjects showed higher levels of depression and reduced cognitive functioning, which were linked to reduced sleep quality and worsened daily living skills. When comparing the non-active with the institutionalized group, the latter showed higher levels of depression and reduced cognitive functioning, more sleep complaints, and reduced daily living skills.

Our study highlights that an active lifestyle and a non-institutionalized environment, both allowing greater mobility and autonomy, are two factors that positively contribute to the mental and physical well-being of elderly individuals. Furthermore, the healthcare institution context appears to have a greater negative impact on the psycho-physical well-being of the subjects involved compared to a non-active lifestyle.

Mild cognitive impairment (MCI) is characterized by a mild decline in cognitive function and represents a risk stage for dementia in community-dwelling older adults. Exercise and dual-task training have been used to improve physical health, psychosocial health, and cognitive and learning functions in various subjects. However, the optimal time for these interventions has yet to be clearly identified. This study investigated the effects of cognitively loaded physical exercise (CLPE) on cognitive function and physical health in community-dwelling older adults with mild cognitive impairment and compared the differences according to exercise time.

Fifty-one community-dwelling aged 60 years or older with MCI were randomly assigned to 30-min CLPE (30CLPE, n = 17), 60-min CLPE (60CLPE, n = 17), and control (n = 17) groups. The CLPE program consisted of a twice-weekly exercise program for 8 weeks. During the exercise, a dual task was performed to assess cognitive load. The control group performed a typical exercise program at a dementia center during the same period. The Korean version of the Montreal Cognitive Assessment was used to evaluate cognitive function, and various physical health factors were assessed using the handgrip dynamometer and pinch gauge, Senior Fitness Test, dynamic and static balance abilities, and gait variables.

After the intervention, both the 30CLPE and 60CLPE groups showed significant improvements in cognitive function, upper limb strength, senior fitness, balance, and gait (p < 0.05), while the control group showed no significant changes in any of the variables (p > 0.05). In between-group comparisons, both CLPE groups showed significantly improved cognitive and physical functions compared to the control group (p < 0.05). However, there was no significant difference between the 30 CLPE and 60 CLPE groups (p > 0.05).

The results of this study demonstrate that cognitively loaded physical exercise is effective in improving cognitive and physical function in individuals with MCI. Both the 30-min and 60-min sessions resulted in significant improvements, with no statistically significant differences observed between the two durations. This suggests that persistence and consistency of exercise may be more important than the duration of individual sessions.

Clinical Trials.gov: KCT0009053.

Dual-tasking is defined as performing two or more tasks concurrently. This study aimed to investigate the effect of divided attention on movement-related cortical potential (MRCP) during dual-task performance in 11 community-dwelling elderly individuals while the load of the secondary task was altered. MRCP was recorded during a single task (ST), simple dual task (S-DT), and complex dual task (C-DT) as no-, low-, and high-load divided attention tasks, respectively. The ST involved self-paced tapping with an extended right index finger. In the S-DT and C-DT, the subjects simultaneously performed the ST and a visual number counting task with different levels of load. The coefficient of variation of movement frequency was significantly more variable in the C-DT than in the ST. The MRCP amplitude from electroencephalography electrode C3, contralateral to the moving hand, was significantly higher in the C-DT than in the ST. Higher attention diversion led to a significant reduction in MRCP amplitude in the participants. These results suggest that attention division in dual-task situations plays an important role in movement preparation and execution. We propose that MRCP can serve as a marker for screening the ability of older individuals to perform dual-tasks.

Regular exercise is emphasized for the improvement of functional capacity and independence of older adults. This study aimed to compare the effects of a dual-task resistance exercise program and resistance exercise on cognition, mood, depression, physical function, and activities of daily living (ADL) in older adults with cognitive impairment.

A total of 44 older adults participated in the study. Participants were randomly allocated to an experimental group (n = 22) performing a dual-task resistance exercise program for cognitive function improvement and a control group (n = 22) performing a resistance exercise program. Both groups performed the exercise for 40 min per session, three times a week, for 6 weeks (18 sessions). Cognition, mood, depression, functional fitness, and ADL were quantified before and after the intervention using the Mini-Mental State Examination (MMSE), profile of mood states (POMS), geriatric depression scale (GDS), senior fitness test (SFT), and Korean version of ADL, respectively.

There was a significant time and group interaction on the MMSE (p = 0.044). There were no significant time and group interactions in the POMS, GDS, SFT, or ADL. Cognitive function (p < 0.001), mood (p < 0.001), depression (p < 0.001), functional fitness (p < 0.001), and ADL (p < 0.001) significantly improved after dual-task resistance exercise, and cognitive function (p < 0.001), mood (p < 0.001), depression (p < 0.001), functional fitness (p < 0.001), and ADL (p < 0.001) significantly improved after resistance exercise.

Dual-task resistance exercise is more effective than resistance exercise in improving cognitive function in older adults with cognitive impairment. Both dual-task resistance exercise and resistance exercise improves mood, depression, functional fitness, and ADL after the intervention. We propose using dual-task resistance exercises for cognitive and physical health management in the older adults with cognitive impairment.

This study was registered with the Clinical Research Information Service (WHO International Clinical Trials Registry Platform) (Registration ID, KCT0005389; Registration date, 09/09/2020).

Executive function is an important cognitive factor in gait and balance control. Weakening of balance system components and executive functions due to aging may affect walking and balance and increase the risk of falling.

The present study aimed to investigate the relationship between balance and executive function in older individuals and the contributions of physical activity and depression to this relationship.

A total of 84 healthy individuals aged 60 and over were included in the study. In the study, the Timed Up and Go Test (TUG), Mini Balance Evaluation Systems Test (Mini-BESTest), Digit Symbol Substitution Test (DSST), Trail Making Test A and B (TMT A and TMT B), Physical Activity Scale for the Elderly (PASE), and Geriatric Depression Scale (GDS) were applied.

The Mini-BESTest and TUG correlated with DSST, TMT A, and TMT B. GDS was correlated with TUG. PASE was correlated with Mini-BESTest and TUG. Executive functions differed according to education level; DSST, TMT B, and GDS were effective in fall history.

There was a significant relationship between balance and executive function. It was found that balance and walking speed increased as executive function skills increased. Depression and physical activity are associated with balance and gait speed.

Balance and executive functions are related to each other, and physical activity and depression contribute to this relationship. In order to protect against the negative effects of aging, cognitive and physical training can be performed to prevent balance and executive function declines.

Mild cognitive impairment (MCI) negatively impacts cognition and dual-task abilities. A physical-cognitive integrated treatment approach could mitigate this risk for dementia.

To compare the effectiveness of cognitively enhanced tai ji quan versus standard tai ji quan or stretching exercise in improving global cognition and reducing dual-task walking costs in older adults with MCI or self-reported memory concerns.

3-group, randomized (1:1:1), superiority trial. (ClinicalTrials.gov: NCT04070703).

Community residential homes.

318 older adults with self-reported memory decline or concern and a Clinical Dementia Rating (CDR) global score of 0.5 or lower at baseline.

Cognitively enhanced tai ji quan (n = 105), standard tai ji quan (n = 107), or stretching (n = 106). All groups exercised at home via real-time videoconferencing, 1 hour semiweekly for 24 weeks.

The co-primary endpoints were change in Montreal Cognitive Assessment (MoCA; range, 0 to 30) and dual-task walking costs (difference between single- and dual-task gait speed, expressed in percentage) from baseline to 24 weeks. Secondary outcomes included CDR-Sum of Boxes (CDR-SB), Trail Making Test B, Digit Span Backward (DSB), and physical performance tests. Outcomes were assessed at 16, 24 (primary endpoint), and 48 weeks (6 months after intervention).

A total of 304 participants (96%) completed the 24-week assessment. Cognitively enhanced tai ji quan outperformed standard tai ji quan and stretching with a greater improvement in MoCA score (mean difference, 1.5 points [98.75% CI, 0.7 to 2.2 points] and 2.8 points [CI, 2.1 to 3.6 points], respectively) and in dual-task walking (mean difference, 9.9% [CI, 2.8% to 16.6%] and 22% [CI, 13% to 31%], respectively). The intervention effects persisted at 48-week follow-up.

There was no nonexercise control group; participants had subjective or mild cognitive impairment.

Among community-dwelling older adults with MCI, cognitively enriched tai ji quan therapy was superior to standard tai ji quan and stretching exercise in improving global cognition and reducing dual-task gait interference, with outcomes sustained at 48 weeks.

National Institute on Aging.