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Peng H, Yao N, Song YP, Huang L, Chen HB, Jiang Y, Chen QG. Motoric cognitive risk syndrome: A review of fall risk assessment and management strategies. World J Psychiatry 2025; 15:101800. [DOI: 10.5498/wjp.v15.i4.101800] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/26/2024] [Revised: 11/09/2024] [Accepted: 01/24/2025] [Indexed: 03/25/2025] Open
Abstract
The aging global population is driving an increase in dementia, making the early identification of at-risk individuals crucial. Studies have shown that elderly people often exhibit a slowing gait before dementia diagnosis, which is linked to cognitive decline and predicts dementia risk. With 30% of those over 65 years of age experiencing falls annually, managing fall risk is essential. Motoric cognitive risk syndrome (MCR), characterized by subjective memory impairment and slow gait, is a pre-dementia condition that can identify high-risk individuals without extensive evaluation. The prevalence of MCR varies globally and is associated with an increased risk of falls, disability, and death. Early screening and intervention for MCR can delay dementia and improve fall regulation, offering a new perspective on elderly health management. This review synthesizes the current understanding of MCR-related falls, evaluates risk assessment methods, and discusses health strategies to provide a theoretical basis for fall prevention in community-dwelling older adults.
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Affiliation(s)
- Hao Peng
- College of Physical Education, Yunnan Normal University, Kunming 650500, Yunnan Province, China
| | - Na Yao
- Department of Rehabilitation, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, Yunnan Province, China
| | - Yan-Ping Song
- Department of Rehabilitation, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, Yunnan Province, China
| | - Li Huang
- Department of Rehabilitation, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, Yunnan Province, China
| | - Hong-Bo Chen
- Department of Rehabilitation, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, Yunnan Province, China
| | - Yang Jiang
- College of Physical Education, Yunnan Normal University, Kunming 650500, Yunnan Province, China
| | - Qi-Gang Chen
- Department of Rehabilitation, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650011, Yunnan Province, China
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Delbari A, Azimi A, Pakmehr A, Saatchi M, Bidkhori M, Tabatabaei FS, Rashedi V, Hooshmand E. Association of Obesity, Sarcopenia, and Functional Mobility with Risk of Fall: A Cross-Sectional Study from Ardakan Cohort Study on Aging (ACSA). Med J Islam Repub Iran 2024; 38:114. [PMID: 39781315 PMCID: PMC11707710 DOI: 10.47176/mjiri.38.114] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/18/2023] [Indexed: 01/12/2025] Open
Abstract
Background Falls are considered one of the leading causes of accidental deaths and nonfatal accidental injuries in older adults. Previous research indicates a 1-in-5 yearly fall incidence among Iranian older adults. To examine specific risk factors within this population, our study aimed to evaluate fall risk factors such as obesity, sarcopenia, functional mobility, and activities of daily living (ADL) scores. Methods This cross-sectional study used data from the first wave of the Ardakan Cohort Study on Aging (ACSA), involving participants ˃50 years who lived in Ardakan, Iran. The primary outcome was fall history in the past 12 months. The main biomechanical variables included body mass index (BMI), muscle strength, gait speed, static balance, and mobility-assisting devices. Sarcopenia was assessed based on the ratio of hand grip strength to BMI. Multiple logistic regressions assessed associations by odds ratio (OR) and 95% confidence interval. Results The final analysis included 4983 participants, 994 of whom reported at least 1 fall. Participants had a mean age of 62.21 ± 4.47 years (50-86 years), with a 48% male distribution. The results of multivariable logistic regression indicated that obesity (OR, 1.02 [95% CI, 0.70- 1.47]; P = 0.910), waist-to-hip ratio (OR, 1.02 [95% CI, 0.74-1.40]; P = 0.903), hand grip strength (OR, 1.20 [95% CI, 0.87-1.66]; P = 0.255), and sarcopenia (OR, 1.11 [95% CI, 0.82- 1.51]; P = 0.474) did not have significant associations with falls. However, impaired standing balance test (OR: 1.64 [95% CI, 1.09-2.47]; P = 0.017) and dependency on ADL (OR, 1.94 [95% CI, 1.05-3.56]; P = 0.032) increased falling. Conclusion Impaired balance tests and dependency on ADL increase the risk of falls in older adults. However, obesity indicators, sarcopenia, and gait speed were not associated with the risk of falls.
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Affiliation(s)
- Ahmad Delbari
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Amirali Azimi
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
- Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Azin Pakmehr
- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| | - Mohammad Saatchi
- Department of Biostatistics and Epidemiology, University of Social Welfare and Rehabilitation Science, Tehran, Iran
- Health in Emergency and Disaster Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Mohammad Bidkhori
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Fatemeh-sadat Tabatabaei
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Vahid Rashedi
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Elham Hooshmand
- Iranian Research Center on Aging, Department of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
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Taylor KA, Carroll MK, Short SA, Celestin BE, Gilbertson A, Olivier CB, Haddad F, Cauwenberghs N. Factors associated with lower quarter performance-based balance and strength tests: a cross-sectional analysis from the project baseline health study. Front Sports Act Living 2024; 6:1393332. [PMID: 39081837 PMCID: PMC11287662 DOI: 10.3389/fspor.2024.1393332] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2024] [Accepted: 06/27/2024] [Indexed: 08/02/2024] Open
Abstract
Objectives Physical performance tests are predictive of mortality and may screen for certain health conditions (e.g., sarcopenia); however, their diagnostic and/or prognostic value has primarily been studied in age-limited or disease-specific cohorts. Our objective was to identify the most salient characteristics associated with three lower quarter balance and strength tests in a cohort of community-dwelling adults. Methods We applied a stacked elastic net approach on detailed data on sociodemographic, health and health-related behaviors, and biomarker data from the first visit of the Project Baseline Health Study (N = 2,502) to determine which variables were most associated with three physical performance measures: single-legged balance test (SLBT), sitting-rising test (SRT), and 30-second chair-stand test (30CST). Analyses were stratified by age (<65 and ≥65). Results Female sex, Black or African American race, lower educational attainment, and health conditions such as non-alcoholic fatty liver disease and cardiovascular conditions (e.g., hypertension) were consistently associated with worse performance across all three tests. Several other health conditions were associated with either better or worse test performance, depending on age group and test. C-reactive protein was the only laboratory value associated with performance across age and test groups with some consistency. Conclusions Our results highlighted previously identified and several novel salient factors associated with performance on the SLBT, SRT, and 30CST. These tests could represent affordable, noninvasive biomarkers of prevalent and/or future disease in adult individuals; future research should validate these findings. Clinical Trial Registration ClinicalTrials.gov, identifier NCT03154346, registered on May 15, 2017.
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Affiliation(s)
- Kenneth A. Taylor
- Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States
- Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States
| | | | | | - Bettia E. Celestin
- Allergy and Immunology, Stanford University School of Medicine, Stanford, CA, United States
| | - Adam Gilbertson
- Durham Veterans Affairs (VA) Healthcare System, Durham, NC, United States
| | - Christoph B. Olivier
- Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany
| | - Francois Haddad
- Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States
- Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States
- Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, United States
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Cui M, Wang J, Deng M, Meng H, Fan Y, Ku C, Wang R, Wu B, Dai M, Ping Z. Longitudinal relationship between grip strength and cognitive function in a European population older than 50 years: A cross-lagged panel model. Arch Gerontol Geriatr 2024; 122:105396. [PMID: 38484671 DOI: 10.1016/j.archger.2024.105396] [Citation(s) in RCA: 4] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2023] [Revised: 02/28/2024] [Accepted: 03/02/2024] [Indexed: 05/08/2024]
Abstract
OBJECTIVES The aim of this study was to investigate the dynamic longitudinal relationship between grip strength and cognitive function. METHODS 6175 participants aged ≥50 years were included in the study using three waves of follow-up data from the Survey of Health, Ageing, and Retirement in Europe in 2015 (T1), 2017 (T2) and 2019 (T3). Cognitive function was assessed using numeracy, verbal fluency, immediate recall, delayed recall and total. The cross-lagged panel model was used for analysis. RESULTS There was a correlation between grip strength and cognitive function. Standardized path coefficient from numeracy T1 to grip strength T2 was 0.017 (p = 0.003), and from numeracy T2 to grip strength T3 was 0.014 (p = 0.012). Standardized path coefficient from grip strength T1 to numeracy T2 was 0.096 (p < 0.001), and from grip strength T2 to numeracy T3 was 0.113 (p < 0.001). Other indicators of cognitive function had similar relationships with grip strength. CONCLUSIONS The study found a statistically significant longitudinal and bidirectional relationship between grip strength and cognitive function in a sample of people aged ≥50 years from several European countries.
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Affiliation(s)
- Man Cui
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Juan Wang
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Miao Deng
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Hailan Meng
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Yanshuai Fan
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Chaoyue Ku
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Ruizhe Wang
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Binbin Wu
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Man Dai
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China
| | - Zhiguang Ping
- College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
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Zhao C, Wang T, Yu D, Li W. Physical exercise habits are related with reduced prevalence of falling among elderly women in China. BMC Womens Health 2023; 23:653. [PMID: 38066469 PMCID: PMC10704620 DOI: 10.1186/s12905-023-02808-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/22/2023] [Accepted: 11/26/2023] [Indexed: 12/18/2023] Open
Abstract
BACKGROUND Although some studies have examined the association between exercise and falls, most have focused on specific exercises, and the results have been inconsistent. In addition, there is a lack of evidence on elderly Chinese women who have different living and exercise habits compared to those in other countries. Therefore, this study aimed to investigate whether physical exercise is associated with falls in elderly Chinese women. METHODS This cross-sectional study included 1429 elderly Chinese women with a mean age of 69.2 years. Information on physical exercise habits and fall experiences was collected using a self-report questionnaire. Logistic regression models were used to analyze the association between physical exercise habits and falls. RESULTS The results showed that 15% participants had a fall in the past year. After adjusting for confounding factors, the odd ratios (ORs) and 95% Confidence Intervals (CIs) for fall experiences across categories of exercise frequency were as follow: 1 (reference) for no exercise behavior, 0.50 (0.29, 0.85) for exercise 1 to 5 times a week, and 0.37 (0.25, 0.55) for exercise more than 6 times a week. Furthermore, the ORs (95% CIs) across categories of exercise insistence were 1 (reference) for less than 1 year, 0.78 (0.37, 1.65) for 1 to 3 years, and 0.38 (0.20, 0.74) for more than 3 years. In terms of exercise duration, the ORs (95% CIs) for < 1 h/day, 1-2 h/day, and > 2 h/day were 1 (reference), 0.85 (0.53, 1.36), and 2.80 (1.30, 6.05). Unlike other variables, longer exercise duration was associated unfavorably with falls. CONCLUSION Physical exercise habits were associated with falls in elderly Chinese women. Keeping a proper exercise habit may contribute to lower risk of falling in elderly women.
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Affiliation(s)
- Cuiqing Zhao
- Division of Physical Education, Myongji University, Seoul, 03674, South Korea.
| | - Tongling Wang
- Institute of Physical Education, Huzhou University, Huzhou, Zhejiang Province, 313000, People's Republic of China.
| | - Dawei Yu
- Institute of Physical Education, Huzhou University, Huzhou, Zhejiang Province, 313000, People's Republic of China
| | - Wang Li
- Department of Physical Education, Huaiyin Institute of Technology, Huaian, Jiangsu Province, 223003, People's Republic of China
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Liu JYW, Yin YH, Kor PPK, Kwan RYC, Lee PH, Chien WT, Siu PM, Hill KD. Effects of an individualised exercise programme plus Behavioural Change Enhancement (BCE) strategies for managing fatigue in frail older adults: a cluster randomised controlled trial. BMC Geriatr 2023; 23:370. [PMID: 37328797 PMCID: PMC10273765 DOI: 10.1186/s12877-023-04080-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/24/2022] [Accepted: 05/31/2023] [Indexed: 06/18/2023] Open
Abstract
BACKGROUND To the best of our knowledge, although ageing-induced fatigue could cause adverse outcomes such as frailty, there is currently no intervention for it. This study evaluated the effects of an individualised exercise programme with/without BCE strategies on reducing fatigue in older adults. METHODS A three-armed cluster-randomised controlled trial (RCT) was conducted with 184 participants (mean age: 79.1 ± 6.4; mean frailty score: 2.8 + 0.8) from 21 community centres (ClinicalTrials.gov: NCT03394495). They were randomised into either: the COMB group (n = 64), receiving 16 weeks of exercise training plus the BCE programme; the EXER group (n = 65), receiving exercise training and health talks; or the control group (n = 55), receiving only health talks. Fatigue was assessed using the Multi-dimensional Fatigue Inventory (range: 20 to 100, with higher scores indicating higher fatigue levels) at baseline, and immediately, 6 months, and 12 months post-intervention. RESULTS The GEE analyses showed significant interaction (time x group) between the COMB and control groups immediately (p < 0.001), 6 months (p < 0.001), and 12 months (p < 0.001) post-intervention. Comparing the COMB and EXER groups, there was a significant interaction immediately (p = 0.013) and at 12 months post-intervention (p = 0.007). However, no significant difference was seen between the EXER group and control group at any time point. CONCLUSIONS The COMB intervention showed better immediate and sustainable effects (i.e., 12 months after the intervention) on reducing fatigue in frail older adults than exercise training or health education alone. TRIAL REGISTRATION ClinicalTrials.gov (NCT03394495), registered on 09/01/2018.
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Affiliation(s)
- Justina Y W Liu
- Centre for Gerontological Nursing, School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
- Research Institute of Smart Ageing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
| | - Yue-Heng Yin
- Centre for Gerontological Nursing, School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Patrick P K Kor
- Centre for Gerontological Nursing, School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Rick Y C Kwan
- Centre for Gerontological Nursing, School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Paul H Lee
- Southampton Clinical Trials Unit, University of Southampton, Southampton, UK
| | - Wai Tong Chien
- Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
| | - Parco M Siu
- Division of Kinesiology, School of Public Health, The University of Hong Kong, Hong Kong SAR, China
| | - Keith D Hill
- Rehabilitation Ageing and Independent Living (RAIL) Research Centre, School of Primary and Allied Health Care, Monash University, Melbourne, 3800, Australia
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