• Hemodialysis patients
• Hope
• Psychological distress
• Self-efficacy

• Humans
• Self Efficacy
• Renal Dialysis/psychology
• Male
• Female
• Cross-Sectional Studies
• Middle Aged
• Psychological Distress
• Iran
• Hope
• Adult
• Aged
• Surveys and Questionnaires
• Stress, Psychological/psychology
• Renal Insufficiency, Chronic/psychology
• Renal Insufficiency, Chronic/therapy

• depression
• end stage renal disease
• hemodialysis
• mortality
• renal function

• Early-stage chronic kidney disease
• Proteinuria
• Suicide

• Humans
• Male
• Female
• Middle Aged
• Renal Insufficiency, Chronic/psychology
• Renal Insufficiency, Chronic/diagnosis
• Renal Insufficiency, Chronic/epidemiology
• Renal Insufficiency, Chronic/physiopathology
• Risk Factors
• Republic of Korea/epidemiology
• Retrospective Studies
• Suicide/statistics & numerical data
• Suicide/psychology
• Aged
• Adult
• Glomerular Filtration Rate
• Incidence
• Comorbidity
• Albuminuria/psychology
• Albuminuria/epidemiology
• Risk Assessment

• 800-20190571 College of Medicine, Seoul National University
• RS-2024-00345867 National Research Foundation of Korea
• Seoul National University Hospital

• Hemodialysis
• depression screening
• differential item functioning
• multiple indicator multiple cause modeling
• structural equation modeling

• Humans
• Renal Dialysis/adverse effects
• Renal Dialysis/psychology
• Female
• Male
• Middle Aged
• Depression/etiology
• Depression/diagnosis
• Quality of Life
• Aged
• Ohio/epidemiology
• Kidney Failure, Chronic/therapy
• Kidney Failure, Chronic/psychology
• Kidney Failure, Chronic/complications
• Adult
• Surveys and Questionnaires
• Mass Screening/methods

• R01 DK112905 NIDDK NIH HHS

• animal protein
• dietary protein
• hemodialysis
• plant protein
• quality of life
• sleep quality

• Aged
• Comorbidity
• Depression
• Dialysis
• Survival

• Kyungpook National University Hospital

• anxiety
• chronic kidney disease
• cognitive impairment
• depression
• end-stage renal disease (esrd)
• quality of life
• renal transplant

• CHARLS
• crucial factors
• depression
• interpretable machine learning
• middle-aged and older adults

• Cross-sectional studies
• dietary fiber
• kidney failure, chronic
• renal dialysis
• sleep quality

• depression
• hemodialysis
• intracellular water
• total body water

• Guizhou Science and Technology Plan Project
• Guizhou High-level innovative Talent Project

• Cardiovascular risk
• Psychosocial risk factors

• Bibliometric
• Depression
• Dialysis
• Hot issues
• Scopus

• Anxiety
• Depression
• Family function
• Hope
• Maintenance hemodialysis

• LHHL2020ZD-02 Health Commission of Hubei Provincial
• LHHL2020ZD-02 Health Commission of Hubei Provincial
• LHHL2020ZD-02 Health Commission of Hubei Provincial
• 2022KFH028 Key Laboratory of Hubei Province
• 2022KFH028 Key Laboratory of Hubei Province
• 2022KFH028 Key Laboratory of Hubei Province

• ADPKD
• Anxiety
• Depression
• Polycystic kidney
• Psychosocial risk
• Quality of life

• depression
• health-related quality of life (HRQOL)
• hemodialysis
• kidney failure
• medication adherence

• Humans
• Male
• Female
• Adult
• Middle Aged
• Aged
• Quality of Life
• Prevalence
• Depression/epidemiology
• Prospective Studies
• Medication Adherence
• Renal Insufficiency, Chronic/epidemiology

• anxiety
• depression
• dialysis
• mental health
• surveys and questionnaires

• Depression
• directly observed treatment
• end-stage renal disease
• fluoxetine
• hemodialysis

• R01 DK112905 NIDDK NIH HHS

• Health disparities
• ethnic disparities
• mental health
• quality of life
• racial disparities

• hemodialysis
• Depressive symptoms clusters
• malnutrition
• muscle function
• physical performance

• Aged
• China
• Cross-Sectional Studies
• Depression/complications
• Hand Strength
• Humans
• Male
• Malnutrition/complications
• Malnutrition/diagnosis
• Medically Unexplained Symptoms
• Muscle, Skeletal/physiology
• Nutritional Status
• Postural Balance
• Renal Dialysis/adverse effects
• Time and Motion Studies

Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex.

CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m²) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0–100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders.

Overall kidney function decline in 1326 patients was –0.12 mL/min/1.73 m²/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03–1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality).

There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men.

We aimed to describe (1) depressive and anxiety symptom burdens reported by adults on in-centre hemodialysis in Northern Alberta, Canada and (2) patients’ and nurses’ perceptions of managing such symptoms using routine patient-reported outcome measures (PROMs).

A longitudinal mixed methods approach was employed. Cluster randomized controlled trial data exposed the prevalence of positive screens (scores ≥ 3) for depressive (PHQ-2) and anxiety (GAD-2) symptoms. A descriptive qualitative approach was used to understand patients’ and nurses’ perceptions of managing these symptoms using the ESAS-r: Renal and EQ-5D-5L. Using purposeful sampling, patients and nurses were invited for interviews. Field notes were documented from 6 dialysis unit observations. Patients’ responses to open-ended survey questions and nurses’ electronic chart notes related to mental health were compiled. Thematic and content analyses were used.

Average age of patients (n = 408) was 64.0 years (SD 15.4), 57% were male, and 87% were not working; 29% screened positive for depressive symptoms, 21% for anxiety symptoms, and 16% for both. From patient (n = 10) and nurse (n = 8) interviews, unit observations, patient survey responses (n = 779) and nurses’ chart notes (n = 84), we discerned that PROMs (ESAS-r: Renal/EQ-5D-5L) had the potential to identify and prompt management of mental health concerns. However, opinions differed about whether mental health was within kidney care scope. Nonetheless, participants agreed there was a lack of mental health resources.

Prevalence of depressive and anxiety symptoms aligned with existing literature. Tensions regarding mental health management highlight the need for systemic decisions about how routine PROM use, including mental health assessment, may be optimized to meet patients’ needs.

The online version contains supplementary material available at 10.1186/s41687-021-00385-z.

• Anxiety symptoms
• Chronic hemodialysis
• Depressive symptoms
• Mental health
• PROMs

To date, hemodialysis (HD) is the most common therapy for chronic kidney disease (CKD) patients. However, it causes different complications such as sleep disorders. Sleep regulation is connected to vitamin D; hence, its deficiency might influence the quality and duration of sleep. This study is aimed at evaluating the correlation of sleep quality and vitamin D levels in 80 HD patients.

This cross-sectional study was performed on 80 hemodialysis patients admitted to 29 Bahman hospitals in Tabriz, Iran. Before beginning of dialysis, serum 25 (OH) D levels were assessed among patients and the sleep patterns and sleep quality of patients were accurately calculated by the Pittsburgh sleep quality index (PSQI) standard questionnaire.

Our results showed that 22 HD patients (27.5%) had severe sleep disorders. In addition, it was found that serum levels of vitamin D had significant correlation with sleep quality (r = −0.341, p = 0.002) in general, even after adjusting confounding factors such as calcium (Ca), phosphate (P), and parathyroid hormone (PTH) level. In poor sleepers (PSQI ≤ 5), a negative correlation was observed between the levels of vitamin D and PSQI score (r = −0.397, p = 0.004). PSQI scores in the normal range of PTH (r = −0.377, p = 0.006) and in >600 pg/ml of PTH (r = −0.675, p = 0.011) had a correlation with vitamin D levels. The level of vitamin D was the single independent predictor of sleep efficiency (β coefficient = −0.386, p = 0.001).

The present project reported that the positive effect of vitamin D is associated with sleep disorder in HD patients. In future studies, normal levels of Ca and P should be considered along with normal vitamin D levels among the included patients.

Health-related quality of life is recognized as a key outcome in chronic disease management, including kidney disease. With no national healthcare coverage for hemodialysis, Ugandan patients struggle to pay for their care, driving families and communities into poverty. Studies in developed countries show that patients on hemodialysis may prioritize quality of life over survival time, but there is a dearth of information on this in developing countries. We therefore measured the quality of life (QOL) and associated factors in end stage renal disease (ESRD) patients in a major tertiary care hospital in Uganda.

Baseline QOL measurement in a longitudinal cohort study was undertaken using the Kidney Disease Quality of Life Short Form Ver 1.3. Patients were recruited from the adult nephrology unit if aged > 18 years with an estimated glomerular filtration rate ≤ 15mls/min/1,73m². Clinical, demographic and micro-financial information was collected to determine factors associated with QOL scores.

Three hundred sixty-four patients (364) were recruited, of whom 124 were on hemodialysis (HD) and 240 on non-hemodialysis (non-HD) management. Overall, 94.3% of participants scored less than 50 (maximum 100). Mean QOL scores were low across all three principal domains: physical health (HD: 33.14, non-HD: 34.23), mental health (HD: 38.01, non-HD: 38.02), and kidney disease (HD: 35.16, non-HD: 34.00). No statistically significant difference was found between the overall quality of life scores of the two management groups. Breadwinner status (p < 0.001), source of income (p0.026) and hemodialysis management type (p0.032) were the only factors significantly associated with QOL scores, and this was observed in the physical health and kidney disease principal domains only. No factors were significantly associated with scores for the mental health principal domain and/or overall QOL score.

The quality of life of Ugandan patients with ESRD has been found to be lower across all three domains of the Kidney Disease Quality of Life Short Form than reported anywhere in the world, with no difference observed between the non-HD and HD management groups. Interventions targeting all domains of QOL are needed among patients with ESRD in Uganda and, potentially, in other resource limited settings.

• Chronic [MeSH]
• Developing countries [MeSH]
• Kidney failure
• LMIC
• Low and middle income countries
• Palliative care [MeSH]
• Quality of life [MeSH]
• Renal Dialysis [MeSH]
• Resource limited setting

• Hemodialysis
• hemoglobin
• mental health
• probiotic
• quality of life
• synbiotic

• chronic kidney disease
• depression
• end-stage renal disease
• fluoxetine
• hemodialysis

Since the outbreak of the coronavirus epidemic, the “virtual” telemedicine has become a critical substitute for patient-provider interactions. However, virtual encounters often face challenges in the care of patients in high-risk categories such as chronic kidney disease (CKD) patients. In this study, we explore the patient's satisfaction and the practical effects of a newly established telemedicine program on CKD patients' care during the COVID-19 pandemic. Based on a prior version of an online patient care platform established in 2017, we developed a customized and improved online telemedicine program designed to specifically address the challenges emerging from the pandemic. This included an online, smart phone-based strategy for triage and medical care delivery and psychological support. We invited a total of 278 CKD patients to join the new platform during the pandemic. The subjects in group A were patients utilizing our old online CKD system and were historical users registered at least 3 months before the pandemic. A pilot survey interrogating medical and psychological conditions was conducted. Feedback on the program as well as a psychological assessment were collected after 1 month. In total, 181 patients showed active responses to the program, with 289 person-time medical consultations occurring during the study. The virtual care program provided a rapid triage for 17% (30 out of 181) patients, with timely referral to in-patient medical encounters for their worsening medical conditions or severe psychological problems. Nearly all patients (97.4%) believed the program was helpful. The number of symptoms (OR 1.309, 95%CI 1.113–1.541; P = 0.001) and being enrolled during the pandemic (OR 3.939, 95% CI 1.174–13.221; P = 0.026) were associated with high stress. During the follow-up, the high-stress CKD group at baseline showed a significant decrease in avoidance score (6.9 ± 4.7 vs. 9.8 ± 1.9, P = 0.015). In conclusion, during the pandemic, we established an online telemedicine care program for CKD patients that provides a rapid triage function, effective CKD disease management, and potentially essential psychological support.

• chronic kidney disease
• coronavirus
• patient care
• psychological stress
• telemedicine

• IgA nephropathy
• Physical activity
• cardiopulmonary function
• depression
• quality of life
• training program

• Depression/psychology
• Depression/therapy
• Ergometry
• Exercise/psychology
• Exercise Test
• Female
• Glomerulonephritis, IGA/psychology
• Glomerulonephritis, IGA/surgery
• Humans
• Kidney Transplantation
• Male
• Personal Satisfaction
• Prospective Studies
• Psychometrics
• Quality of Life/psychology
• Surveys and Questionnaires