India, with its vast youth population, grapples with significant mental health issues among young adults in higher education, due to factors such as academic pressure, social isolation, stigma, economic uncertainty, screen time, sedentary lifestyles, and pandemic-related stresses. Though the issue has garnered attention, there's a gap in post-pandemic mental health research for Indian students. This study aims to address this by investigating anxiety, depression, and overall mental well-being among students aged 18-29 in higher educational institutions across eight major Indian cities, categorized by gender, zone, city, and institution type. Using a cross-sectional design and multi-stage sampling, we surveyed 1628 students (47.1 % males, 52.9 % females) using the Mental Health Inventory (MHI-38). Female students reported higher distress levels than males. Students from the Western and Southern zones showed higher positivity and well-being. Kolkata students reported low positivity but superior well-being. Hyderabad students reported low depression levels. Central University students reported more depression, while government arts and science college students reported lower life satisfaction. The majority exhibited moderate to high levels of anxiety (69.9 %), depression (59.9 %), loss of behavioral/emotional control (65.1 %), and distress (70.3 %). These statistics underscore the burden of mental health issues faced by this demographic. Despite the prevalence, a minimal number of young adults accessed mental health services, often due to stigma and cultural biases. This study highlights how the post-pandemic context has exacerbated these barriers, revealing significant mental health issues among participants and underscoring the urgent need for targeted interventions in educational institutions amidst rising suicide rates in this demographic.

The COVID-19 pandemic changed employment conditions and childcare availability worldwide. This contributed to higher work-related stress among working parents, which in turn may have led to lower relationship satisfaction. This study examined the prospective associations between psychosocial work stress or work-privacy conflict (WPC) and relationship satisfaction among parents of young children during the first year of the COVID-19 pandemic. Further, this study aimed to investigate a potential mediating role of psychological symptoms, i.e., symptoms of depression and anger/hostility, and to determine whether this applies equally to mothers and fathers. Longitudinal data were derived from the German, prospective cohort study DREAMCORONA. Working and cohabiting mothers (n =  138) and fathers (n =  187) completed questionnaires on psychosocial work stress, WPC, and psychological symptoms from May-June 2020 (T1) and on relationship satisfaction from October-December 2020 (T2). Mediation analyses were conducted separately for mothers and fathers, controlling for working from home and number of children. Mediation effects were found only for fathers. Higher levels of psychosocial work stress were associated with higher levels of symptoms of depression, which in turn predicted lower relationship satisfaction. The prospective association between higher paternal WPC and lower relationship satisfaction was mediated by higher symptoms of both depression and anger/hostility. No mediation effects were found for mothers. However, also in mothers, psychosocial work stress was associated with symptoms of depression, whereas WPC was associated with symptoms of both depression and anger/hostility. This study highlights the importance of identifying protective mechanisms for working parents to maintain mental health and satisfying romantic relationships in times of crisis and beyond. To develop targeted prevention approaches, it appears advantageous to continue examining sex differences. Additionally, it is essential to educate working parents about the potential risks associated with work-related stress and to ensure the availability of stable counselling services.

The network theory of mental disorders offers a new perspective for the understanding of comorbidities, but the research on the comorbidities among depression, anxiety, and post-traumatic stress disorder (PTSD) is still insufficient. The aim of this study was to explore the internal relationship by establishing and analyzing the comorbidity networks, and to provide suggestions for the intervention after traumatic events.

We utilized data from the second and third wave of the Chengdu Positive Child Development cohort (N = 3,189, 47.79% female), we estimated to network models of depression, anxiety and PTSD. To assess difference in global connectivity between the two networks, we conducted invariance test.

K27 (Somatic 10), K37 (Generalized Anxiety 9), K15 (Somatic 5), K33 (Generalized Anxiety 7), K24 (Somatic 9) were the most central nodes in both networks, P13 (Sleep problem) had the highest Bridge Expected Influence value. The structural difference between the two networks was statistically significant (M = 0.229, p = 0.010), and the global strength of the network at wave 2 was higher than the network at wave 3 (35.1 vs. 33.9, S = 1.20, p = 0.010).

The correlation in symptoms of the three disorders underscores the need for more comprehensive treatment options for intervention after traumatic events. Central and bridge nodes could inform targeted interventions or policy decisions. Anxiety disorders, especially Som and Gen dimensions, should be the focus of intervention. The Arousal dimension in PTSD, especially sleep disorders, may contribute to the comorbidities. In addition, this study highlights the importance of staged post-traumatic interventions.

Anxiety disorders are widespread across the world. Understanding the global burden of anxiety disorders in the past and future can provide important references for optimizing prevention and control strategies in healthcare systems.

The estimation of anxiety disorders in the Global Burden of Disease Study 2021 using systematic review was conducted to describe incidence, prevalence and disability adjusted life years (DALYs) in 204 countries and regions from 1990 to 2021. Trends were examined using joinpoint regression analysis and correlation between Sociodemographic Index (SDI) and temporal trends was assessed.

In 2021, the global age-standardised prevalence rate (ASPR), age-standardised incidence rate (ASIR), and age-standardised DALYs rates for anxiety disorders were 4421.9 (95 % uncertainty intervals [UIs] 3768.3 to 5182.1), 678.3(565.2 to 832.4), and 524.3(363.1 to 716.3) per 100,000 population, which were 18 %, 20.6 %, and 18.2 % higher than in 1990, respectively. In 2021, Brazil (9007.4), Portugal (9712.4), and Paraguay (8390) had the highest ASPR of anxiety disorders. Brazil (53.2 %), Peru (38.4 %), and Bolivia (42.2 %) showed the largest increases in ASPR across the study period. In women, the global DALY rate of anxiety disorders increased up to age 20-44 years and then decreased with advancing age, whereas for men the rate the same as in women. Regionally, an overall undulating pattern association was found between SDI and the age standardised DALYs rate of anxiety disorders. The global female ASIR slightly increased from 1990 to 2019 (Annual percent change [APC]: 0.02 %). However, from 2019 to 2021, it saw a substantial rise (APC: 10.78 %).

With the development of society, the disease burden of anxiety disorder will become increasingly severe. It is very important to study the accurate epidemiological data on anxiety disorder for clinical diagnosis and treatment and health policy.

The COVID-19 pandemic has led to the implementation of social distancing measures on an unprecedented scale, but their impacts on the mental health of the general public, especially in places with strict and prolonged restrictions, are not well understood. This study explored the Hong Kong public's views on social distancing measures that were implemented approximately two years into the pandemic and examined how these perceptions influence their stay-at-home motivation and mental health based on Protection Motivation Theory (PMT).

A two-phase sequential exploratory mixed-methods study was conducted.

Data were collected as part of a larger study of a universal online public health campaign in Hong Kong.

First, qualitative interviews with 26 participants from diverse backgrounds explored their views on COVID-19 and social distancing measures. Subsequently, a quantitative online survey of 1025 participants from the general population examined the relationship between PMT constructs, stay-at-home motivation, and mental health.

Mental health and PMT constructs, including protective motivation, perceived severity, perceived vulnerability, self-efficacy, response cost, and response efficacy.

The qualitative results identified three themes: 'the inescapable and unpredictable nature of COVID-19', 'stay-at-home impacts all facets of life', and 'the realities and challenges of social distancing during a pandemic'. Subsequently, quantitative findings showed that most PMT constructs, such as perceived severity (ß=0.21, 95% CI=0.15-0.27), perceived vulnerability (ß=0.24, 95% CI=0.18-0.30), self-efficacy (ß=0.27, 95% CI=0.20-0.34) and response efficacy (ß=0.09, 95% CI=0.02-0.15), were associated with stay-at-home motivation (all p<0.01), except for response cost. Higher perceived severity (ß=1.42-1.74), perceived vulnerability (ß=0.93-1.36), and response cost (ß=1.29-1.64) were associated with poorer mental health.

This study examined the public perceptions and experiences of strict and prolonged social distancing measures two years into a global pandemic. The findings highlighted the significance of using the PMT model to understand the factors influencing stay-at-home intentions and their mental health during the pandemic. The findings provide valuable insights to guide the development and implementation of future public health interventions.

The COVID-19 pandemic led to significant reconfiguration of primary care systems internationally. For example, a large proportion of face-to-face appointments have been replaced by telephone or online consultations. As a result, the relationship between primary care appointment provision and some of its key determinants, such as workforce and demographic characteristics, are likely to have changed. Conclusions from previous studies which used only pre-pandemic data may no longer be applicable under these new configurations.

This study aims to investigate whether the relationships between primary care appointment rates and their determinants, including workforce composition and the age structure of registered patients, have changed after the COVID-19 pandemic. We conducted longitudinal analysis on the 106 Clinical Commissioning Groups (CCGs) in England over two periods of 24 months (March 2018 to February 2020 and March 2021 to February 2023). We used fixed-effects regression models to relate monthly general practice appointment rates per registered patient to workforce size and composition and population age structure, and compared the results between the two periods.

In the pre-pandemic period, changes in full time equivalent (FTE) numbers of GP trainees and nurses were the only time-varying variables associated with appointment rates. In the post-lockdown period, the age profile of registered patients became a key determinant of appointment rates. A 1% increase in the proportion of registered patients over 80 years was associated with a 0.165 (38.7%) increase in appointments per patient per month. Changes in FTE numbers of qualified GPs and direct patient care staff were not found to influence the appointment rate in either period.

The relationships between primary care appointment rates and the workforce composition and population age structure have changed following the COVID-19 pandemic. The proportion of registered patients over the age of 80 years is now the most significant time-varying driver of appointment rates. General practices serving older patients may face much higher demand and have a bigger challenge providing sufficient appointments in the future compared to before the pandemic.

Bus drivers face complex work challenges and high infection risks, particularly heightened during the COVID-19 pandemic, which significantly affects their mental health. This study used network analysis to conduct a longitudinal follow-up of the psychological symptom network of bus drivers, utilizing the Symptom Checklist-90-Revised (SCL-90-R).

A repeated-measures self-controlled observational design was used to survey 1,600 intercity bus drivers in a city in southern Anhui, China, in September 2022 and January 2023, respectively, and participant data were analyzed using regularized partial correlation network analysis.

A total of 1134 (74.56%) completed the two surveys, 1121 (98.9%) were male, with a mean age of 47.3 ± 6.27 years, and all had junior high school education and above. The results showed a significant reduction in the severity of psychological symptoms among bus drivers the second time around. Anxiety remained the core symptom in the network; however, depression emerged as a secondary core symptom following the relaxation of policies related to COVID-19. Additionally, the weights of significant edges in the symptom network also changed.

Although this study lacked causal inference and relied on self-reported symptoms, it reveals changes in bus drivers' psychological symptom networks under two psychological physical examinations, highlighting the implications of COVID-19 and subsequent policy changes for future research and intervention to improve mental health among this population.

Background/Objectives: The recent COVID-19 pandemic posed a significant psychological challenge for healthcare workers. Resilience and the extent of psychological stress varied across professional groups and individual circumstances. This study aims to longitudinally capture the trajectories of psychological stress and resilience among medical personnel during the pandemic and identify various contributing factors. Methods: Over a period of three years, healthcare workers from five locations (Bonn, Cologne, Ulm, Erlangen, and Dresden) were surveyed regarding their psychological stress (PHQ-4) and other aspects of mental health. Data were collected at five different points during the pandemic. Using Growth Mixture Modeling (GMM), various stress trajectories during the crisis were modeled without initial adjustment for covariates to allow for an unbiased identification of latent classes. Differences in demographic and occupational factors (e.g., age, gender, profession) were analyzed across the identified trajectory groups in subsequent steps. Results: The application of GMM revealed three distinct profiles of psychological stress and resilience among the respondents, largely consistent with the literature. The largest group was the 'resilience' group (81%), followed by the 'recovery' (10%) and 'delayed' groups (9%). Group membership was consistent with self-reported trajectories over the course of the pandemic. It was not possible to predict individual trajectories based on the results of a short resilience questionnaire (RS-5). Conclusions: The COVID-19 pandemic had multiple psychological impacts on healthcare workers, manifesting in clearly differentiated group trajectories of distress over time. While a majority of respondents in this sample exhibited a stable trajectory with low distress, other groups showed varying stress responses over time. These findings highlight the necessity of longitudinal approaches to understand the complex interplay of stressors and coping mechanisms during prolonged crises.

The COVID-19 pandemic emerged as an international public health emergency and threat to individual psychological resilience.

To examine the prevalence of psychological issues and identify key associations with mental health indicators in young adults (ages 18-28) worldwide during the initial phase of the pandemic.

Through a cross-sectional online survey utilizing convenience sampling, we collected data on demographics, COVID-19-related questions, depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), stress/trauma (Impact of Event Scale-Revised), and fear of COVID-19 (Fear of COVID-19 scale) between September 2020-January 2021. A total of 183 were eligible analysis. All statistical analyses were set at alpha = 0.05.

Over 70% of participants reported mild anxiety (n=129), 80% mild depression (n=136), 40% pandemic-related trauma (n=61), and 50% high fear (n=88). Female respondents reported higher anxiety (t(173)=-3.352, <.001), depression (t(166)=-3.310, P=.001), and trauma from COVID-19 ((t(151)=-2.004, P=.047). Hispanic/Latino/a/x participants reported higher depression (F(2,156)=7.761, P<.001) and trauma scores (F(2,143)=3.999, P=.020). Age in 2020 was associated with trauma total scores (F(1,154)=4.230, P=0.041, R2 = 0.027). Individuals who were mandated a quarantine were linked to lower levels of anxiety (F(2,175)=3.442, P=.034) and depression (F(2,170)=3.092, P =.048) than those not mandated. Those quarantined with close contacts were linked to lower anxiety (t(162.184)=2.705, P =.008) and trauma (t(149)=2.169; P=.032). Close contacts' hospitalization from COVID-19 infections were linked to lower anxiety (t(127)=2.855, P=.005), depression(t(123)=3.111, P=.002), and trauma (t(152)=-1.975, P=.050).

The findings highlight the significant effect COVID-19 had on mental health in young adults worldwide.

The workplace is an important setting for improving population psychological health. This study aimed to identify priority industries and populations in Australia with highest adverse effects of psychological distress. The study included 5834 workers aged 18 to 64 years who participated in the 2020 to 2021 National Health Survey. Logistic regression analyses were used to estimate the prevalence of psychological distress by industry, age group, and gender. Productivity losses were analyzed using negative binomial regression. Increased odds of experiencing distress were found for younger workers 18 to 29 years (odds ratio [OR] = 2. 45) and female workers (OR = 1.52). Industry of employment did not impact distress once age and gender were accounted for (P = .956). Being highly/very highly distressed resulted in a mean of 21.56 more distress-related loss days per year (0.78 vs 22.34) compared with low/moderate distress. Targeted and tailored workplace intervention programs for these groups are required to build a healthy and productive future workforce.

The COVID-19 pandemic generated mental health stressors for parents as they faced new health risks and navigated disruptions to employment, schooling, and care arrangements. Drawing on 2021 survey data from Canadian parents of children 10 years old and younger, we describe the relationship between work/care pandemic stressors and mental health, and employ Kitagawa-Oaxaca-Blinder decompositions to examine how these contribute to mental health gaps by gender and its intersection with having household members perceived to be at high risk in relation to COVID-19. We find that mothers' mental health was more negatively affected than fathers'. Differences in exposure to work/care stressors help explain this gap, with the "mental load," perceptions of inequity in how households responded to pandemic care demands, and greater reported deterioration in work-family balance and career prospects particularly salient. Mothers, but not fathers, with high-risk household members were also more exposed to key work/care stressors, contributing to the worst pandemic mental health for this group. While the relationship between stressors and mental health was similar for mothers and fathers overall, high-risk status moderated this relationship, with employment or care disruptions that reduced COVID-19 exposure less likely to be associated with poorer mental health for parents in high-risk families.

The relationship between changes in mental health during the severe and sustained stresses of the COVID-19 pandemic and exposure to childhood maltreatment is not well-characterized despite the recognition of early life adversity as a pervasive risk factor for adverse mental health outcomes throughout the lifespan. To determine whether a history of childhood maltreatment was associated with vulnerable mental health trajectories during the pandemic, we analyzed data from the CovSocial study, a longitudinal online study that assessed 3,522 adult respondents from Berlin, Germany at seven time points during the pandemic, including two lockdowns. Exposure to childhood maltreatment was assessed with the Childhood Trauma Questionnaire. The main outcome was membership in one of four latent mental health profile classes identified in a previous study from dynamic changes of resilience-vulnerability factor scores that captured variance in longitudinal measures of vulnerability (depression, anxiety, stress, burdens) and resilience (coping, optimism, social support). Exposure to childhood maltreatment significantly increased the odds of belonging to the most vulnerable compared to the most resilient latent class (OR, 4.66 [95 % CI, 3.57, 5.98]). On average, individuals with exposure had a greater mental health burden at baseline compared to non-exposed individuals (p < 0.001, Cohen's d = 0.24) and increasing mental health problems during the second sustained lockdown (p = 0.003, Cohen's d = 0.18). Our results suggest that individuals who experienced childhood maltreatment are at increased risk for mental health problems during the pandemic, emphasizing the need for detection of cases and targeted interventions during future crises.

Psychosocial safety climate (PSC) refers to the collective belief among workers regarding the protection and support of their psychological health and safety by senior management. Despite the recognized importance of PSC in mitigating exposure to detrimental psychosocial risk factors at work, a validated instrument in French is lacking. This study aimed to evaluate the psychometric properties of the French-Canadian version of the PSC-12 and its associations with job satisfaction and psychological distress.

A cross-sectional validation study was conducted to evaluate the psychometric properties of the PSC-12. Using cross-sectional data from an online survey of adults in a French-Canadian university (n = 1,784), the psychometric properties of the PSC-12, a 12-item questionnaire, were assessed. Internal consistency, validity, and factor structure were examined through exploratory factor analysis conducted using SAS v.9.4 software.

Confirming the original four-factor structure, the French-Canadian version of the PSC-12 demonstrated satisfactory internal consistency (Cronbach's α of 0.95) and validity indices. Its convergent and divergent validity was evidenced by a positive association with job satisfaction (r = 0.34, p < 0.05) and the negative association with psychological distress (r = -0.50, p < 0.05).

The French-Canadian adaptation of the PSC-12 maintains cross-cultural validity, providing a validated and concise tool for assessment within the French-Canadian community. Practical Applications: By facilitating the prevention of mental health problems among workers, this questionnaire has the potential to contribute to alleviating burdens for individuals, workplaces, and society.

People living with HIV (PLWH) have a higher prevalence of mental ill health compared to the general population. We aimed to understand the impact of the COVID-19 pandemic and omitting routine HIV appointments on the mental health (MH) of PLWH. Between April 2020 and March 2021, routine appointments for "stable" PLWH were replaced by virtual consultations. MH assessments using standardised questionnaires were compared before and during the pandemic. Full data were available for 426 individuals after excluding those with incomplete data and those requiring early review for non-MH-related issues. The results showed that 277 (65%) experienced no/minimal MH symptoms throughout, indicating robust MH. For depression, scores worsened in 59 (13.8%), improved in 62 (14.6%) and remained stable in 305 (71.6%). For anxiety, scores worsened in 55 (12.9%), improved in 64 (15%) and remained stable in 307 (72.1%). A total of 98.4% of individuals remained virally suppressed, with 7 developing a detectable viral load. One person stopped antiretroviral treatment secondary to an MH crisis. Findings suggest that the COVID-19 pandemic did not significantly impact the overall MH in our cohort of PLWH. It also demonstrates an effective implementation of virtual consultations. The complex nature of MH in PLWH highlights the need for individualised MH care.

BackgroundThe Movement Control Orders (MCO) in Malaysia due to the COVID-19 pandemic had a profound impact on the lifestyle behaviours, weight changes, and mental health of the population.AimTo determine the changes in physical activity, sedentary behaviour, body weight status and mental health status among Malaysian adults before and during the pandemic.MethodsA total of 338 Malaysian adults participated in this cross-sectional online study. Sociodemographic and anthropometric data were self-reported. Physical activity and sedentary behaviour were assessed using International Physical Activity Questionnaire-Short Form (IPAQ-SF) while the Perceived Stress Scale (PSS-10), Patient Health Questionnaire (PHQ-9) and Generalised Anxiety Disorder Assessment (GAD-7) were used to examine stress, depression and anxiety, respectively. All statistical analysis was performed using SPSS version 28.0.ResultsThe results showed an average weight gain of 0.6 kg among the participants with 45.5% of them experiencing weight gain. In addition, sedentary behaviour (p < 0.001), PSS-10 score (p < 0.001), PHQ-9 score (p = 0.002) and GAD-7 score (p = 0.001) were significantly increased during the COVID-19 pandemic whereas the level of physical activity was significantly decreased (p = 0.003) during the pandemic. Weight changes during the pandemic were found to be associated with age, sedentary hours, and PHQ-9 score. Through binary logistic regression, sedentary hours (AOR = 1.068, 95% CI = 1.002-1.139, p = 0.043) were identified to be a risk factor for weight gain during the pandemic.ConclusionThe findings suggested that public health interventions to prevent weight gain should focus on strategies to increase physical activity for sedentary lifestyles.

In recent years, mental health in Austria has faced substantial challenges due to a series of both global and regional crises.

This study aimed to assess changes in mental health indicators within the Austrian population over time from April 2022 to October 2024 and to identify sociodemographic correlates of poor mental health.

Two cross-sectional online surveys on representative samples of the Austrian general population were conducted at two timepoints: April 2022 (n = 1,032) and October 2024 (n = 2,025). Mental health indicators, including depression, anxiety, insomnia, alcohol misuse, and stress, were measured using validated scales. Sociodemographic data were collected to examine associations with mental health indicators. Chi-squared tests and t-tests were conducted to compare mental health indicators between 2022 and 2024, and multivariable logistic regression models were applied to examine associations with sociodemographic data.

Clinically relevant symptoms of depression and high stress decreased from 2022 to 2024 (depression from 28.3% to 21.6%, stress from 56.3% to 51.0%; p < 0.01), while other symptoms remained stable. Sociodemographic analysis revealed that female gender, younger age, lower income, unemployment, migration background and lack of partnership were associated with higher odds for several mental health issues.

Findings suggest small improvements in mental health from 2022 to 2024 and identified sociodemographic risk factors linked to mental health vulnerabilities.

Understanding factors associated with protective immunity against emerging viral infections is crucial for global health. Pakistan reported its first COVID-19 case on 26 February 2020, but experienced relatively low COVID-19-related morbidity and mortality between 2020 and 2022. The underlying reasons for this remain unclear, and our research aims to shed light on this crucial issue.

We conducted a serial population-based serosurvey over 16 months (rounds 1-4, July 2020 to November 2021) across households in urban (Karachi) and rural (Matiari) Sindh, sampling 1100 households and 3900 individuals. We measured antibodies in sera and tested a subset of respiratory samples for COVID-19 using polymerase chain reaction (PCR) and antigen tests, also measuring haemoglobin (Hb), C-reactive protein (CRP), vitamin D, and zinc in round 1.

Participants showed 23% (95% confidence interval (CI) = 21.9-24.5) antibody seroprevalence in round 1, increasing across rounds 2-4 to 29% (95% CI = 27.4-30.6), 49% (95% CI = 47.2-50.9), and 79% (95% CI = 77.4-80.8), respectively. Urban residents had 2.6 times (95% CI = 1.9-3.6) higher odds of seropositivity than rural residents. Seropositivity did not differ between genders. Individuals aged 20-49 years had 7.5 (95% CI = 4.6-12.4) times higher odds of seropositivity compared to children aged 0-4 years. Most participants had no symptoms associated with COVID-19, with no reported mortality. Vitamin D deficiency was linked to seroprevalence. COVID-19 was confirmed in 1.8% of individuals tested via RT-PCR and antigen tests.

The data suggests a steady increase in humoral immunity in Pakistan, likely due to increased transmission and associated asymptomatic disease. Overall, this reflects the longitudinal trend of protection against severe acute respiratory syndrome coronavirus 2, leading to the relatively low morbidity and mortality observed in the population.

The COVID-19 pandemic affected mental health worldwide. The COSMO-Spain study analyses risk perceptions, behaviours, knowledge and other pandemic related variables, such as well-being. This work aimed to assess the evolution of self-reported well-being in Spain from May 2021 to September 2022 and its association with demographic and COVID-19 related factors.

An online, nationwide cross-sectional panel survey was applied in seven rounds with 1000+ participants each, with a total sample of 7266 participants, representative of the Spanish adult general population. The main variable was well-being, measured with the World Health Organization Well-Being Index (WHO-5) total score, an index with a total score from 0 to 100 (0 = worst well-being, 100 = best well-being). Other variables included in the survey were: sociodemographic data, concern about COVID-19, feelings of depression and fear, COVID-19-related worries, risk perception, self-efficacy, preventive behaviours, pandemic fatigue, health literacy, information search behaviours, and trust in several institutions. A multiple linear regression was run to analyse the associated factors with the WHO-5 total score.

The WHO-5 total score showed a significant increase from rounds 6 (May-June 2021) to 8 (September-October 2021). Women (standardized b coefficient (b) = -0.10), youth or people with lower socioeconomic status (worsened financial situation (b = -0.10) or unemployed/furloughs (b = -0.04)) reported lower well-being levels, whereas having a university-level education showed the opposite (b = 0.11). Feeling less depressed was associated with higher well-being (b = 0.31).

This study shows rising levels of well-being until a plateau was reached in October 2021. Vulnerable groups may be at higher risk of worsened mental health and should be addressed by policymakers. Further longitudinal studies should evaluate causality and evolution patterns of well-being throughout the COVID-19 pandemic.

A cross-sectional survey conducted between July and September 2020 and August and September 2021 estimated the prevalence and predictors of common mental disorders (CMDs) and post-traumatic stress disorder (PTSD) among healthcare workers (HCWs) at an infectious disease referral center during the COVID-19 pandemic. CMDs were assessed using the General Health Questionnaire (GHQ-12), and PTSD using the Impact of Event Scale-Revised (IES-R). Multivariate logistic regressions identified predictors of CMD and PTSD. The study included 371 HCWs in 2020 and 167 in 2021. The CMD prevalence was 34.3% (95% confidence interval (CI): 29.5-39.4) in 2020 and 30.5% (95% CI: 23.7-38.1) in 2021. The PTSD prevalence was 25.4% (95% CI: 21.0-30.2) in 2020 and 32.7% (95% CI: 25.6-40.5) in 2021. Factors increasing CMD odds included lower education (adjusted odds ratio (AOR) = 3.71, 95% CI: 1.60-8.61), lack of physical activity (AOR = 2.23, 95% CI: 1.33-3.73), and experiencing COVID-19 symptoms (AOR = 1.64, 95% CI: 1.02-2.64) in 2020; chronic diseases (AOR = 3.14, 95% CI: 1.34-7.35) and SARS-CoV-2 testing (AOR = 3.39, 95% CI: 1.13-10.17) raised CMD odds in 2021. Frontline HCWs had lower CMD odds in 2020 (AOR = 0.60, 95% CI: 0.36-1.00) and 2021 (AOR = 0.33, 95% CI: 0.14-0.75). PTSD was associated with having COVID-19 symptoms (AOR = 2.06, 95% CI: 1.23-3.45), living with high-risk individuals (AOR = 1.75, 95% CI: 1.03-2.95), and losing loved ones (AOR = 1.86, 95% CI: 1.09-3.17) in 2020. Chronic diseases increased PTSD odds in 2020 (AOR = 2.20, 95% CI: 1.25-3.86) and 2021 (AOR = 2.30, 95% CI: 1.03-5.13), while age decreased them in 2020 (AOR = 0.95, 95% CI: 0.93-0.98) and 2021 (AOR = 0.95, 95% CI: 0.91-0.99). Younger HCWs with chronic conditions living with high-risk individuals were particularly affected. These findings highlight the urgent need for targeted emotional support and stress management programs for HCWs.

Young people with childhood adversity (CA) were at increased risk to experience mental health problems during the COVID-19 pandemic. Pre-pandemic research identified high-quality friendship support as a protective factor that can buffer against the emergence of mental health problems in young people with CA. This longitudinal study investigated friendship buffering effects on mental health symptoms before and at three timepoints during the pandemic in 102 young people (aged 16-26) with low to moderate CA. Multilevel analyses revealed a continuous increase in depression symptoms following the outbreak. Friendship quality was perceived as elevated during lockdowns and returned to pre-pandemic baseline levels during reopening. A stress-sensitizing effect of CA on social functioning was evident, as social thinning occurred following the outbreak. Bivariate latent change score modeling revealed that before and during the pandemic, young people with greater friendship quality self-reported lower depression symptoms and vice versa. Furthermore, sequential mediation analysis showed that high-quality friendships before the pandemic buffered depression symptoms during the pandemic through reducing perceived stress. These findings highlight the importance of fostering stable and supportive friendships in young people with CA and suggest that through reducing stress perceptions high-quality friendships can mitigate mental health problems during times of multidimensional stress.

To evaluate whether osteopathic and related manual interventions improve adult mental health (depression, anxiety, stress) and psychophysiological measures (eg, heart rate variability, skin conductance).

Systematic review and meta-analysis of randomised controlled trials (RCTs).

PubMed, MEDLINE (Ovid), Scopus, Cochrane, and AMED, searched through September 2024.

English-language RCTs with ≥30 participants investigating osteopathic or related manual therapies (eg, myofascial release, high-velocity low-amplitude thrusts) delivered by qualified practitioners, compared with no treatment or sham, and reporting immediate postintervention mental health or psychophysiological outcomes.

Full-text screening, risk-of-bias assessment and data extraction were conducted independently by multiple reviewers using a standardised Joanna Briggs Institute (JBI) Extraction Form. Risk of bias was assessed using the JBI Critical Appraisal Checklist. For meta-analyses, Hedges' g (with 95% CIs) was calculated from postintervention means and SD. Random-effects models accounted for heterogeneity, and prediction intervals were calculated to assess uncertainty in effect estimates.

20 RCTs were included. Osteopathic interventions reduced depression (Hedges' g=-0.47, 95% CI: -0.86 to -0.09, p=0.02) and increased skin conductance (Hedges' g=0.67, 95% CI: 0.00 to 1.34, p=0.05). Depression improvements were greater in pain populations (Hedges' g=-0.61, 95% CI: -1.06 to -0.17, p=0.01). However, wide prediction intervals and moderate heterogeneity indicate uncertainty in true effect sizes, and limited studies and sample sizes restrict assessment of publication bias.

Osteopathic and related manual therapies may reduce depression and influence certain psychophysiological markers, particularly in pain populations, but uncertainty and heterogeneity limit confidence. More rigorous, larger, and longitudinal RCTs are needed.

This meta-analysis was not formally registered, though the protocol and search strategy can be found at Open Science Framework, registration identification: https://osf.io/jrtpx/.

Objective: This study aimed to examine college students' perceived mental health and help-seeking behaviors during the COVID-19 pandemic, as well as to determine the roles of campus mental health climate and institutional support on students' help-seeking behaviors and well-being. Participants: The sample included 123 students from a Northeastern United States University. Methods: Using a web-based survey and convenience sampling, data were collected in late 2021. Results: Most participants retrospectively reported a perceived decline in their mental health during the pandemic. Sixty-five percent of the participants reported that they did not receive professional help at a time when they needed it. Both campus mental health climate and institutional support were negatively related to anxiety symptoms. Greater institutional support predicted less social isolation. Conclusions: Our findings highlight the importance of campus climate and support on students' well-being during the pandemic and the need for increasing students' access to mental health care.

The coronavirus disease 2019 (COVID-19) pandemic was accompanied by an increase in mental health challenges including depression, stress, loneliness, and anxiety. Common genetic variants can contribute to the risk for psychiatric disorders and may present a risk factor in times of crises. However, it is unclear to what extent polygenic risk played a role in the mental health response to the COVID-19 pandemic. In this study, we investigate whether polygenic scores (PGSs) for mental health-related traits can distinguish between four resilience-vulnerability trajectories identified during the COVID-19 pandemic and associated lockdowns in 2020/21. We used multinomial regression in a genotyped subsample (n = 1316) of the CovSocial project. The most resilient trajectory characterized by the lowest mental health burden and the highest recovery rates served as the reference group. Compared to this most resilient trajectory, a higher value on the PGS for the well-being spectrum decreased the odds for individuals to be in one of the more vulnerable trajectories (adjusted R-square = 0.3%). Conversely, a higher value on the PGS for neuroticism increased the odds for individuals to be in one of the more vulnerable trajectories (adjusted R-square = 0.2%). Latent change in mental health burden extracted from the resilience-vulnerability trajectories was not associated with any PGS. Although our findings support an influence of PGS on mental health during COVID-19, the small added explained variance suggests limited utility of such genetic markers for the identification of vulnerable individuals in the general population.

There has been widespread concern about the mental health impact of the global COVID-19 outbreak. Fears have been raised that depression and anxiety among older people may have increased in the pandemic, and that adverse health behaviours, such as increased alcohol use and decreased physical activity, may have contributed to the mental health decline. This study aimed to examine changes in depression, anxiety, alcohol use and physical activity scores of people aged 55 and older in New Zealand over the initial months of the pandemic. The sample included 3,171 people who responded to wave 7 (August-November 2018) and wave 8 (June-September 2020) of the Health, Work and Retirement Study. Analyses were carried out using paired t tests and multilevel mediation modelling. There was no evidence of significant changes in depression or anxiety. Alcohol use and physical activity were shown to decrease significantly, albeit to a small degree, and there was evidence of an indirect effect of time on depression via physical activity. These findings suggest a general resilience among older people 3 to 6 months into the pandemic. However, increased attention should be paid to promoting physical exercise among older people, as a means of decreasing depression risk.

The COVID-19 pandemic's impact on mental health is challenging to quantify because pre-existing risk, disease burden and public policy varied across individuals, time and regions. Longitudinal, within-person analyses can determine whether pandemic-related changes in social isolation impacted mental health. We analyzed time-varying associations between psychiatric vulnerability, loneliness, psychological distress and social distancing in a US-based study during the first year of the pandemic. We surveyed 3,655 participants about psychological health and COVID-19-related circumstances every 2 weeks for 6 months. We combined self-reports with regional social distancing estimates and a classifier that predicted probability of psychiatric diagnosis at enrollment. Loneliness and psychiatric vulnerability both impacted psychological distress. Loneliness and distress were also linked to social isolation and stress associated with distancing, and psychiatric vulnerability shaped how regional distancing affected loneliness across time. Public health policies should address loneliness when encouraging social distancing, particularly in those at risk for psychiatric conditions.

Physical inactivity and sedentary behavior are associated with mental ill-health. We examined changes in leisure-time physical activity (LTPA) and sedentary time, and their associations with psychological distress in an occupational cohort.

We used phase 1 survey data, collected among the employees of the City of Helsinki, Finland, aged 19-39 years in 2017, and phase 2 follow-up survey from 2022 (n = 1914 participants, 75% women). A 4-category variable (High→High, Low→High, High→Low, and Low→Low) was constructed for both LTPA and sedentary time to reflect the change over time. The 21-item Depression, Anxiety and Stress Scale was used to measure psychological distress. Logistic regression analysis estimated odds ratios (ORs) and their 95% CIs, adjusting for sociodemographic factors, working conditions, health-related factors, and physician-diagnosed mental disorders at phase 1.

Repeated low LTPA was associated with anxiety (OR = 2.03; 95% CI, 1.44-2.85), depressive (OR = 1.69; 95% CI, 1.22-2.36), and stress (OR = 2.22; 95% CI, 1.58-3.12) symptoms after adjusting for gender and age, compared with repeated high LTPA. The associations remained after full adjustments in anxiety (OR = 1.57; 95% CI, 1.08-2.30) and stress (OR = 1.92; 95% CI, 1.32-2.78) symptoms. Additionally, a change from high to low LTPA was associated with anxiety (OR = 1.47; 95% CI, 1.05-2.04) symptoms after full adjustments.

Repeated low levels of LTPA are associated with anxiety and stress symptoms. No consistent associations between sitting time and psychological distress could be confirmed. Considering the increasing levels of psychological distress in recent years, particularly among younger adults, it is essential to explore effective countermeasures through large interventions or prospective study designs.

This study investigates the mediating role of perceived social support in the relationship between unemployment and mental distress among young healthcare graduates in Bolivia during the COVID-19 pandemic.

A cross-sectional analysis within a cohort study was conducted using data from 109 healthcare graduates from Bolivia collected through an online survey in 2022. The survey measured employment status, mental distress with the 12-item General Health Questionnaire (GHQ-12), and perceived social support using the Multidimensional Scale of Perceived Social Support (MSPSS). Mediation analysis was performed in R to examine the mediating effect of perceived social support on the relationship between unemployment and mental distress.

More than two-thirds of participants reported mental distress. Consistent with the main effect model, employment was directly associated with lower levels of mental distress, and perceived social support was positively related to better mental health. However, perceived social support did not statistically significant mediate the impact of unemployment on mental distress, with only 2.1% of the effect being mediated through perceived social support.

Despite the beneficial effect of perceived social support on mental health, it did not significantly mediate the relationship between unemployment and mental distress among Bolivian healthcare graduates during COVID-19. The findings highlight the need for targeted mental health support that go beyond social support for unemployed healthcare graduates during crises.

Quality of life (QoL) is an important measure of overall well-being linked to physical, mental, social, and environmental aspects of health. This study aimed to assess the QoL among healthcare workers (HCWs) in hospitals and primary healthcare centers (PHCs) in Gaza Strip, Palestine.

A cross-sectional study was conducted among 1850 HCWs in Gaza Strip, Palestine. Data were collected by using self-administered questionnaires in the paper-based format containing a sociodemographic profile and the World Health Organization Quality of Life Brief questionnaire. Factors associated with QoL were examined using an independent t-test, Chi-square test, and multivariate logistic regression models.

The study included HCWs with a mean age of 38.62 years old, of whom 61.9% were male. The mean QoL score was 55.98 (standard deviation: 11.50), with 55.5% reporting a good QoL. Multivariate logistic regression analysis revealed that age, smoking status, workplace, and work shifts were associated with the overall QoL score (p < 0.05). Older age (≥ 35 years), working in a hospital, and working the morning shifts were identified as protective factors for QoL, while smoking and working the evening-night shifts were inversely associated with QoL.

This study found that HCWs in Gaza Strip exhibited moderate levels of QoL. Age, smoking status, workplace, and work shifts were associated with overall QoL. Strategies to improve HCWs' QoL, such as lifestyle interventions, additional support through training or educational programs, and reducing work schedules, could be considered under high-pressure situations.

The COVID-19 pandemic led to public health crises beyond the direct casualties from the virus itself. This study assesses the impact of COVID-19 on suicide rates in South Korea, which implemented effective policy interventions against COVID-19 and has one of the highest suicide rates among member states of the Organisation for Economic Co-operation and Development (OECD).

A county fixed effects model.

We analyze county-level data covering the 2017-2022 period from the National Statistical Office of Korea and use a county fixed effects model. The primary outcome is the suicide rate per 100,000 population. Our main analysis compares pre-pandemic suicide rates (2019) with those during the pandemic (2020-2022) at bimonthly frequency, focusing on the population aged 20-59 years.

We find that, in contrast to the initial global concerns about potential increases in suicide because of pandemic-related stress, suicide rates significantly decreased during the pandemic. However, this trend was not uniform: young women experienced fluctuating suicide rates, highlighting a demographic-specific impact. The study also finds that both people who died by suicide and people who died of other non-suicide causes were more likely to have a college diploma and were less likely to be married. Additionally, there are mixed results regarding the location of death. Overall, the pandemic appears to have had a complex effect on suicide behaviors in South Korea.

The findings underscore the need for targeted mental health interventions, especially for vulnerable groups such as young women. The findings also emphasize the importance of considering demographic-specific responses in public health strategies to better address the mental health consequences of large-scale crises.

Since the mid-20th century, mental illness has become a leading cause of health burden, particularly among adolescents and emerging adults, with most disorders emerging before the age of 25. Over the past two decades, mental ill health has surged to alarming levels, with evidence confirming that the increase is not just due to better awareness or diagnosis but reflects a genuine public health crisis.

We explore the evolving landscape of youth mental health and its contributing factors, including family dynamics, educational pressures, climate change, social media, and socio-economic challenges, potentially linked to neoliberal policies. A narrative review methodology was employed to analyze these factors and their role in the trends of mental ill-health among young people.

We document mental health trends since the mid-1990s, focusing on mental and substance use disorders among young people and their current needs. Potential new explanatory factors and megatrends, potentially flowing from a paradigm shift in the global political economy which has largely passed under the radar, yet which has produced fragmentation and inequality, are identified, with the COVID-19 pandemic further intensifying these trends. We discuss methodologies to estimate the contribution of these megatrends and outline potential barriers to implementation, along with strategies to overcome them.

This review calls for a comprehensive global action plan, emphasizing prevention, early intervention, and improved treatment strategies. In addition to strengthening prevention, which may take time and be elusive, immediate action is needed to innovate and expand services, which are currently under-resourced and overwhelmed.

Limited research has examined whether accumulation of discrimination over time is associated with worse mental health and whether such experiences are related to socioeconomic status (SES).

A sample of UK adults with self-reported discrimination experiences (n = 3863) was taken from three waves of the UK Household Longitudinal Study (2015-2020). Multinomial logistic regression assessed associations between SES (income, education, occupation) and cumulative discrimination (number of timepoints discrimination was reported). Logistic regression models assessed prospective associations between cumulative discrimination and probable mental health problems (GHQ-12; 4+ threshold).

Those with lower income were more likely to report discrimination at one timepoint (vs. none). No SES measures were associated with experiencing discrimination at multiple timepoints. Participants who reported one timepoint of discrimination (vs. no experiences) were significantly more likely to report probable mental health problems (OR = 1.47, p < .001, 95% CI 1.20-1.80). Moreover, compared to those experiencing one timepoint, participants reporting multiple timepoints of discrimination were significantly more likely to report probable mental health problems (OR = 1.46, p = .002, 95% CI 1.15-1.86), indicating a cumulative association between discrimination and mental health. There was limited evidence that SES moderated this cumulative association.

Mental health measures were based on self-report questionnaires and not a clinical diagnosis.

Amongst a sample of UK adults, perceiving discrimination at multiple timepoints increased the likelihood of experiencing probable mental health problems. There was limited evidence that this cumulative association differed by SES. National measures designed to reduce discrimination may benefit mental health.

There is an urgent need to better understand the factors that predict mental wellbeing in vocationally active adults during globally turbulent times.

To explore the relationship between psychological detachment from work (postulated as a key recovery activity from work) in the first national COVID-19 lockdown with health, wellbeing, and life satisfaction of working age-adults one year later, within the context of a global pandemic.

Wellbeing of the Workforce (WoW) was a prospective longitudinal cohort study, with two waves of data collection (Time 1, April-June 2020: T1 n = 337; Time 2, March-April 2021: T2 = 169) corresponding with the first and third national COVID-19 lockdowns in the UK. Participants were >18 years, who were employed or self-employed and working in the UK. Descriptive and parametric (t-tests and linear regression) and nonparametric (chi square tests) inferential statistics were employed.

Risk for major depression (T1: 20.0% to T2: 29.0%, p = .002), poor general health (T1: 4.7% to T2: 0%, p = .002) and poor life satisfaction (T1: 15.4% to T2: 25.4%, p = .002) worsened over time, moderate-to-severe anxiety remained stable (T1: 26.1% to T2: 30.2%, p = .15). Low psychological detachment from work was more prevalent in the first wave (T1: 21.4% and T2: 16.0%), with a moderate improvement observed from T1 to T2 (t (129) = -7.09, p < .001). No differences were observed with work status (employed/self-employed), except for self-employed workers being more likely to report poor general health at T1 (16.1%, p = .002). Better psychological wellbeing, lower anxiety and higher life satisfaction at T2 were observed in those who reported better psychological detachment from work at T1 (β = .21, p = .01; β = -.43, p < .001; β = .32, p = .003, respectively), and in those who improved in this recovery activity from T1 to T2 (β = .36, p < .001; β = -.27, p < .001; β = .27, p = .008, respectively), controlling for age, gender and ethnicity.

The ability to psychologically detach from work during the first pandemic lockdown, and improvement in this recovery activity over time, predicted better mental wellbeing and quality of life in vocationally active adults after one year of a global crisis, irrespective of work status. Interventions to encourage workers to psychologically detach from work may help to support employee wellbeing at all times, not only in the extreme circumstances of pandemics and economic uncertainty.

Substantial evidence indicates that the COVID-19 pandemic has adversely affected population mental health globally. However, most studies assumed a linear relationship where only negative pandemic-induced changes led to worse mental health outcomes, overlooking the complex relationship between COVID-19-related changes and mental health. This study examined how various types and magnitudes of pandemic-related changes relate to depression and suicidal thoughts in a large, nationwide adult population sample.

We analyzed data from the 2021 Korean Community Health Survey, a cross-sectional survey of 229,213 adults. The study examined the association between mental health outcomes and three types of pandemic-related changes: daily life impact (scored 0-100), economic activities (employment and income changes), and health behaviors (physical activity, instant food consumption, alcohol consumption, and smoking). Complex sample multiple logistic regression analysis was used to assess these associations, adjusting for sociodemographic factors.

The relationship between pandemic-related changes and mental health showed non-linear patterns. Compared to those reporting moderate changes, individuals reporting either no change (depression: aOR 1.253, 95% CI 1.135-1.384; suicidal thoughts: aOR 1.355, 95% CI 1.236-1.486) or complete disruption (depression: aOR 1.895, 95% CI 1.667-2.155; suicidal thoughts: aOR 1.788, 95% CI 1.558-2.052) in daily life showed higher risks of poor mental health. Unexpectedly, positive changes such as improved working conditions (suicidal thoughts: aOR 1.419, 95% CI 1.200-1.677) and increased income (depression: aOR 1.304, 95% CI 1.139-1.493; suicidal thoughts: aOR 1.244, 95% CI 1.079-1.435) were also associated with adverse mental health outcomes.

This study reveals that both minimal and substantial changes in daily life, as well as both positive and negative changes in economic conditions and health behaviors, were associated with poor mental health outcomes during the pandemic. These findings suggest the need for comprehensive mental health interventions that consider various types and magnitudes of life changes during crisis situations.

Research shows initial COVID-19 lockdowns increased population mental distress. Yet, the mental health impact of repeated lockdowns in England remains unknown.

To: (a) explore changes in population mental health symptoms over the COVID-19 pandemic period (March 2020 to March 2021) in England, comparing this with trends from a decade before (2009-2019) as well as after (2021-2023); (b) compare the mental health impact of each of the three lockdowns in England with periods of eased restrictions, determining who was most affected; (c) examine the impact of demographics and distinct time periods on the prevalence of mental health symptoms.

A secondary analysis of a national longitudinal cohort study, utilising data from Waves 1-13 of the UK Household Longitudinal Study and from Waves 1-9 of the COVID-19 Survey. Mental health was assessed using the 12-item General Health Questionnaire. Student t-tests and logistical regressions were conducted.

There was a significant increase in the prevalence of self-reported symptoms of mental health during England's pandemic period, encompassing three lockdowns, compared with the average of rates from 10 years before. Rates of reported mental health symptoms were not significantly different across each lockdown, but were significantly higher than pre-pandemic rates, declining with eased restrictions. Rates from the end of lockdown to May 2023 revealed elevated mental health symptoms compared with pre-pandemic. Elevated symptoms were observed for women, people homeworking, those with health conditions, individuals aged 30-45 years and those experiencing loneliness.

Repeated lockdowns in England had a substantial impact on mental health, indicating requirements for ongoing mental health support.

Adolescence and young adulthood are sensitive developmental periods to environmental influences. Investigating pre-emptive measures against stressors, such as those associated with the COVID-19 pandemic, on mental health is crucial. We aimed to synthesize evidence on pre-pandemic resilience factors shaping youth mental health outcomes during this period. For this pre-registered systematic review, we searched seven databases for longitudinal studies of youth populations affected by the COVID-19 pandemic, assessing a priori defined resilience factors at the individual, family, or community level before the pandemic. Studies required validated mental health or wellbeing measures collected both before and during the pandemic. Study quality was assessed using the corresponding NIH Quality Assessment Tool. From 4,419 unique records, 32 studies across 12 countries were included, using 46 distinct resilience measures. Due to the heterogeneity of study designs, we applied a narrative synthesis approach, finding that resilience factors were generally associated with better mental health outcomes both prior to and during the pandemic. However, most factors did not mitigate pandemic-related mental health effects. Nonetheless, family-level resilience factors emerged as promising under specific conditions. Study quality was generally fair, with concerns in resilience assessment and sampling quality. Future research should prioritize rigorous study designs and comprehensive resilience assessments.

We investigated people living with HIV (PLWH)'s exposure to COVID-19 pandemic stressors and their association with distress, psychological growth, and substance use. PLWH in the ANRS CO3 AQUIVIH-NA cohort's QuAliV study (Nouvelle Aquitaine, France) completed an adapted CAIR Lab Pandemic Impact Questionnaire (C-PIQ) and reported substance use between 9/2021 to 3/2022. We described cumulative stressor exposure (score 0-16) and explored variation by PLWH characteristics (demographic, HIV-related, risk factors, psychosocial). Associations with distress (score 0-23), psychological growth (score 0-20), and substance use were assessed using regression models. Participants reported exposure to a median of 2 (IQR: 1-4) stressors. Stressor exposure was higher in working-age (<60) and psychosocially vulnerable PLWH. Exposure to an additional stressor correlated with a 0.7-point increase in distress scores (95% C.I. 0.5-1.0, p<0.001), a 0.04-point increase (95% C.I. 0.01-0.07, p=0.002) in psychological growth scores in working-age PLWH. In older PLWH, additional stressor correlated with a 0.8-point (95% C.I. 0.4-1.2, p<0.001) increase in distress and a 0.1-point increase (95% C.I. 0.06-0.2, p=0.001) in growth scores. Each additional stressor was associated with 1.2 (95% C.I. 1.0-1.4, p=0.02) higher adjusted odds of cannabis use in working-age PLWH, and 1.2 (95% C.I. 1.0-1.4, p=0.004) higher adjusted odds of drug use. Exposure to stressors was linked to increased distress, cannabis and drug use but also growth. Providers should not only be aware of risk (of severe COVID-19) but also be mindful of the social and psychological challenges PLWH face as these may affect their retention in care, especially during challenging times.

Based on nationally representative panel data (N person-years = 40,020; N persons = 18,704; Panel Labour Market and Social Security; PASS) from 2018 to 2022, we investigate how mental health changed during and after the COVID-19 pandemic. We employ time-distributed fixed effects regressions to show that mental health (Mental Health Component Summary Score of the SF-12) decreased from the first COVID-19 wave in 2020 onward, leading to the most pronounced mental health decreases during the Delta wave, which began in August 2021. In the summer of 2022, mental health had not returned to baseline levels. An analysis of the subdomains of the mental health measure indicates that long-term negative mental health changes are mainly driven by declines in psychological well-being and calmness. Furthermore, our results indicate no clear patterns of heterogeneity between age groups, sex, income, education, migrant status, childcare responsibilities or pre-COVID-19 health status. Thus, the COVID-19 pandemic appears to have had a uniform effect on mental health in the German adult population and did not lead to a widening of health inequalities in the long run.

The impact of the COVID-19 pandemic on the mental health of children and young people (CYP) has been widely reported. Primary care electronic health records were utilised to examine trends in the diagnosing, recording and treating of these common mental disorders by ethnicity and social deprivation in Greater Manchester, England.

Time-series analyses conducted using Greater Manchester Care Record (GMCR) data examined all diagnosed episodes of anxiety disorders and depression and prescribing of anxiolytics and antidepressants among patients aged 6-24 years. The 41-month observation period was split into three epochs: Pre-pandemic (1/2019-2/2020); Pandemic Phase 1 (3/2020-6/2021); Pandemic Phase 2 (7/2021-5/2022). Rate ratios for all CYP specific to sex, age, ethnicity, and neighbourhood-level Indices of Multiple Deprivation (IMD) quintile were modelled using negative binomial regression.

Depression and anxiety disorder rates were highest in females, CYP aged 19-24, and White and 'Other' ethnic groups. During Pandemic Phase 1, rates for these diagnoses fell in all demographic subgroups and then rose to similar levels as those recorded pre-pandemic. In Pandemic Phase 2, rates in Black and Mixed-ethnicity females rose to a significantly greater degree (by 54% and 62%, respectively) than those in White females. Prescribing rates increased throughout the study period, with significantly greater rises observed in non-White females and males. The temporal trends were mostly homogeneous across deprivation quintiles.

The observed fluctuations in frequency of recorded common mental illness diagnoses likely reflect service accessibility and patients' differential propensities to consult as well as changing levels of distress and psychopathology in the population. However, psychotropic medication prescribing increased throughout the observation period, possibly indicating a sustained decline in mental health among CYP, and also clinicians' responses to problems presented. The comparatively greater increases in frequencies of diagnosis recording and medication prescribing among ethnic minority groups warrants further investigation.

Great Britain has been experiencing a cost-of-living crisis since late 2021, with the cost of everyday essentials rising more quickly than the average household income. This study provides up-to-date information on levels of subjective and objective financial hardship during this crisis, differences across population subgroups, and associations with psychological distress.

We used data from a representative cross-sectional survey of adults (≥16 y) in Great Britain (n = 7,027) conducted January-March 2023. Subjective financial hardship was defined as reporting finding it quite/very difficult to manage financially these days and objective financial hardship as reporting having been in rent/mortgage arrears in the past 12 months. Past-30-day psychological distress was assessed with the K6 and categorised as no/low (scores ≤4), moderate (5-12), and severe distress (≥13). Covariates included sociodemographic characteristics, mental health history, smoking status, and alcohol consumption.

Overall, 12.9% [95%CI = 12.0-13.8%] reported subjective financial hardship and 6.5% [5.8-7.2%] objective financial hardship. Groups experiencing more hardship included non-binary people, ethnic minority groups, less advantaged social grades, those living in private rented or social housing, those unemployed and seeking work or not in paid work for other reasons, those with more children in the household, those with a history of ≥1 mental health conditions, those who currently smoked and those who drank not at all or at very high levels. Subjective/objective financial hardship was associated with greater odds of experiencing moderate (ORadj = 1.96 [1.59-2.42]/ORadj = 1.86 [1.40-2.47]) or severe psychological distress (ORadj = 4.11 [3.07-5.50]/ORadj = 2.23 [1.52-3.29]). These associations between financial hardship and psychological distress were similar across all sociodemographic, mental health, smoking, and alcohol characteristics.

In the first quarter of 2023, around one in eight adults in Great Britain reported finding it difficult to manage financially and one in fifteen reported having been in rent or mortgage arrears in the past 12 months, with higher rates of financial hardship among disadvantaged groups. However, disadvantage did not appear to compound the psychological impact of financial hardship: people experiencing financial hardship were substantially more likely to report moderate or severe psychological distress regardless of their sociodemographic characteristics.

Previous studies have demonstrated deteriorations in young adult mental health during the COVID-19 pandemic, but evidence suggests heterogeneity in the mental health impacts of the pandemic. We sought to identify factors which may predict changes in psychological distress and wellbeing during the COVID-19 pandemic in UK young adults.

A total of 2607 young adults from the Millennium Cohort Study were included. Psychological distress and mental wellbeing were measured using the Kessler-6 and Short Warwick-Edinburgh Mental Wellbeing Scale, respectively. Assessment occurred at three timepoints between the ages of 17-19: 2018/19 (pre-COVID Baseline), May 2020 (COVID Wave 1) and September/October 2020 (COVID Wave 2). Latent change score models were used to study change in distress and wellbeing across the study period, as well as the impact of sex, relative family poverty, parental education, preexisting mental health difficulties and perceived social support on these changes.

The latent change score models suggested both distress and wellbeing tended to increase across the study period. Being female and in relative poverty predicted greater increases in distress and/or poorer wellbeing. Higher levels of parental education and greater perceived social support were protective against increased distress and associated with improved wellbeing.

The impact of the COVID-19 pandemic on UK young adult mental health is complex. We provide further evidence for a distinction between symptoms of poor mental health and wellbeing. Research is urgently needed to assess the long-term impacts of the COVID-19 pandemic on the mental health and wellbeing of young people, particularly in more vulnerable groups.