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Li J, Deng SW. Common and distinct neural substrates of rule- and similarity-based category learning. Cognition 2025; 261:106143. [PMID: 40239456 DOI: 10.1016/j.cognition.2025.106143] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/29/2024] [Revised: 03/14/2025] [Accepted: 04/03/2025] [Indexed: 04/18/2025]
Abstract
Categorization is a fundamental ability in human cognition that enables generalization and promotes decision-making. A categorization problem can be solved by employing a rule-based or a similarity-based strategy. The current study aims to elucidate the brain mechanism for category learning by investigating whether the use of the two strategies is supported by common or distinct neural substrates. We conducted three experiments using stimuli with a rule-plus-similarity category structure and applying an EEG-fNIRS fusion methodology. In Experiment 1, participants were explicitly instructed to use either a rule-based (single feature) or a similarity-based strategy, while in Experiment 3, they were instructed to use a rule-based (multi-feature) or a similarity-based strategy. In contrast, in Experiment 2, participants were required to self-discover categorization strategies. After learning, categorization was tested. The results of the three experiments were largely consistent, revealing distinct decision-making processes associated with each strategy. The results revealed that hypothesis testing and semantic processing, as reflected by the larger P300 and N400 components and increased activation in Wernicke's area, were critical for rule-based category learning, suggesting the role of an explicit system. In contrast, complex visual processing and the integration of multiple features, as indicated by a larger P1 component and the heightened activation in the frontopolar cortex, were critical for similarity-based category learning, suggesting the role of an implicit system. These distinct cognitive processes challenge single-system accounts suggesting a unified neural mechanism for both forms of category learning. Instead, our findings are consistent with the COVIS theory, which implies an explicit system for rule-based category learning and an implicit system for similarity-based category learning.
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Affiliation(s)
- Jianhua Li
- Department of Psychology, Faculty of Social Sciences, University of Macau, China
| | - Sophia W Deng
- Department of Educational Studies, Academy of Future Education, Xi'an Jiaotong-Liverpool University, China.
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Zhao X, Wu M, Liu H, Wang Y, Zhang Z, Liu Y, Zhang Y. Asymmetric Inter-Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants. ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY) 2025; 12:e2309194. [PMID: 40163364 PMCID: PMC12120705 DOI: 10.1002/advs.202309194] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/28/2023] [Revised: 12/03/2024] [Indexed: 04/02/2025]
Abstract
How the lateralized language network and its functions emerge with early auditory experiences remains largely unknown. Here, early auditory development is examined using repeated optical imaging for cochlear implanted (CI) toddlers with congenital deafness from onset of restored hearing to around one year of CI hearing experiences. Machine learning models are constructed to resolve how functional organization of the bilateral language network and its sound processing support the CI children's post-implantation development of auditory and verbal communication skills. Behavioral improvement is predictable by cortical processing as well as by network organization changes, with the highest classification accuracy of 81.57%. For cortical processing, behavioral prediction is better for the left than the right hemisphere and for speech than non-speech processing. For network organization, the best prediction is obtained for resting state, with greater contribution from inter-hemisphere connections between non-homologous regions than from within-hemisphere connections. Most interestingly, systematic connectivity-to-activity models reveal that speech processing of the left language network is developmentally supported largely by global network organization, particularly asymmetric inter-hemisphere communication, rather than functional segregation of local network. These findings collectively confirm the importance of asymmetric inter-hemisphere communication in formation of the lateralized language network and its functional development with early auditory experiences.
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Affiliation(s)
- Xue Zhao
- State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijing100875China
| | - Meiyun Wu
- State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijing100875China
| | - Haotian Liu
- Department of Otolaryngology Head and Neck SurgeryWest China Hospital of Sichuan UniversityChengdu610041China
| | - Yuyang Wang
- Department of Otolaryngology Head and Neck SurgeryHunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University)Changsha410005China
| | - Zhikai Zhang
- Department of Otolaryngology Head and Neck SurgeryBeijing Chao‐Yang HospitalCapital Medical UniversityBeijing100025China
| | - Yuhe Liu
- Department of Otolaryngology Head and Neck SurgeryBeijing Friendship HospitalCapital Medical UniversityBeijing100050China
| | - Yu‐Xuan Zhang
- State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijing100875China
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Ma WJ, Yuan RC, Peng ZY, Wu Q, Al-Matary M, Yang HS, Cheng P, Zhao GJ, Lu CC, Zhang YX, Hong JK, Li WH. Mood symptoms, cognitive function, and changes of brain hemodynamics in patients with COVID-19: A functional near-infrared spectroscopy study. World J Psychiatry 2025; 15:100112. [PMID: 40109999 PMCID: PMC11886312 DOI: 10.5498/wjp.v15.i3.100112] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/08/2024] [Revised: 11/02/2024] [Accepted: 01/10/2025] [Indexed: 02/26/2025] Open
Abstract
BACKGROUND Many patients with coronavirus disease 2019 (COVID-19) may experience emotional issues and cognitive impairment. However, it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of psychopathological symptoms. It remains unclear whether anxiety and depression are caused by stressors or viral infection. AIM To use functional near-infrared spectroscopy (fNIRS) to detect cortical hemodynamic changes in patients with COVID-19 and their relationship with mental symptoms (mainly depression and anxiety), to investigate whether COVID-19 causes these changes by affecting brain function. METHODS A total of 58 subjects, comprising 29 patients with first acute COVID-19 infection and 29 healthy controls without COVID-19 infection and without anxiety or depression were recruited. Then cortical activation during the performance of the verbal fluency test (VFT) and brain connectivity during the resting state (rs) were evaluated by 53-channel fNIRS. For the COVID-19-infected group, Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) were used to assess the emotional state before fNIRS measures. RESULTS For the rs, compared to the uninfected group, the infected group exhibited lower rs functional connectivity (FC) in the dorsolateral prefrontal cortex (DLPFC), which was correlated with both the PHQ score and GAD score. During the VFT, the infected group exhibited significantly lower cortical activation than the uninfected group in both Broca-left and Broca-right. Besides, the integral value in the DLPFC-L showed a significant negative correlation with the PHQ-9 score during the VFT in the infected group. CONCLUSION There were significant differences in the bilateral Broca area and DLPFC between the COVID-19-infected and uninfected groups, which may be the reason why COVID-19 infection impairs cognitive function and language function and leads to psychiatric symptoms. In addition, the rsFC in patients with COVID-19 was positively correlated with the severity of depression and anxiety, which may be related to the fact that the mental symptoms of patients with COVID-19 are characterized by depression and anxiety, rather than depression or anxiety alone. Our study provides evidence that the psychological and emotional issues caused by COVID-19 are not only due to external social factors but also involve more direct brain neural mechanisms and abnormal neural circuits, which also provide insights into the future treatment and prognosis of individuals with COVID-19.
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Affiliation(s)
- Wen-Jin Ma
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Ruo-Chao Yuan
- Research Center of Educational Neuroscience, School of Educational Science, Huazhong University of Science and Technology, Wuhan 430074, Hubei Province, China
| | - Zi-Yu Peng
- Department of Education, Hunan Normal University, Changsha 410081, Hunan Province, China
| | - Qian Wu
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Manal Al-Matary
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Hui-Shu Yang
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Peng Cheng
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Guang-Ju Zhao
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Chao-Chao Lu
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Yue-Xin Zhang
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
| | - Jia-Kun Hong
- Guigang Medical District of No. 923 Hospital, PLA Joint Logistics Support Force, Guigang 537000, Guangxi Zhuang Autonomous Region, China
| | - Wei-Hui Li
- Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
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Zhang H, Shan AD, Huang YY, Gao MX, Wan CH, Ye SY, Gan CT, Sun HM, Cao XY, Yuan YS, Zhang KZ. Transcutaneous auricular vagus nerve stimulation improves cortical functional topological properties and intracortical facilitation in patients with Parkinson's disease. NPJ Parkinsons Dis 2025; 11:38. [PMID: 40025047 PMCID: PMC11873277 DOI: 10.1038/s41531-025-00889-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2024] [Accepted: 02/14/2025] [Indexed: 03/04/2025] Open
Abstract
Our study aimed to investigate the neural mechanisms of taVNS in the motor symptoms of PD, focusing on the topological properties of cortical functional networks and cortical excitability. Thirty-two PD patients underwent functional near-infrared spectroscopy and transcranial magnetic stimulation evaluation prior to and after two-week taVNS, which were controlled by 20 healthy controls (HCs). PD patients exhibited decreased nodal efficiency (Ne) in the right M1 and increased Ne in the left pre-motor and supplementary motor area compared with HCs. The decreased Ne in the right M1 was negatively associated with UPDRS-III scores. Interestingly, taVNS treatment improved PD motor symptoms by increasing Ne in the right M1 and enhancing intracortical facilitation (ICF, ISI 10, and 15 ms). The increased Ne and ICF (ISI 15 ms) were negatively correlated with the decreased UPDRS-III scores. taVNS could improve nodal information processing efficiency in the M1 and enhance cortical facilitation to improve PD motor disorders.
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Affiliation(s)
- Heng Zhang
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Ai-di Shan
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Ya-Yi Huang
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Meng-Xi Gao
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Chen-Hui Wan
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Shi-Yi Ye
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Cai-Ting Gan
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Hui-Min Sun
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Xing-Yue Cao
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Yong-Sheng Yuan
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
| | - Ke-Zhong Zhang
- Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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Ma JY, Wu JJ, Zhu Y, Zheng MX, Hua XY, Xu JG. Investigating autonomic dysfunction in post-COVID-19 syndrome from skin to brain: A case-control study using EMG-SSR and fNIRS. Brain Res Bull 2025; 220:111158. [PMID: 39675490 DOI: 10.1016/j.brainresbull.2024.111158] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/18/2024] [Revised: 11/13/2024] [Accepted: 12/02/2024] [Indexed: 12/17/2024]
Abstract
BACKGROUND Autonomic dysfunction is a well-recognized complication associated with post-COVID-19 syndrome (PCS). ANS maladaptation could underlie a potential pathogenetic mechanism of PCS, contributing to PCS symptoms. However, there remains an ongoing debate regarding whether autonomic and neuropathic symptoms observed in PCS patients are indicative of central or peripheral ANS pathology. The purpose of this study is to investigate both the central and peripheral nervous systems of ANS in patients with PCS. METHODS We evaluated the integrity of the peripheral ANS using sympathetic skin response (SSR) and examined the central ANS using functional near-infrared spectroscopy (fNIRS) covering the fronto-parietal cortex in PCS patients (n = 7) and matched healthy controls (n = 7). Functional connectivity, topological parameters of fNIRS brain network were analyzed. To compare the SSR and fNIRS parameters between patients and age-matched healthy controls, Mann-Whitney U tests were performed for each parameter separately. The AUC of each topological metric of fNIRS network was utilized as a statistical scalar for comparison. To characterize the correlation between SSR and significantly different topological metrics of fNIRS network, Spearman correlation analysis was performed. RESULTS The latencies of palmar SSR were significantly prolonged in the patients with PCS than the controls (p < 0.05). 34 functional connections showed a significant increase (p < 0.05, uncorrected). Regional nodal properties revealed that the fronto-parietal networks of PCS patients had a higher degree in primary somatosensory cortex (S1) (p < 0.001, corrected) and motor cortex, a lower node efficiency in dorsolateral prefrontal cortex (DLPFC), and a higher efficiency in S1 (p < 0.05, uncorrected). Latencies of palmar SSR were significantly positively correlated with zFC within sensorimotor cortex, and node efficiency/degree of S1 (p < 0.01). Amplitudes of palmar and plantar SSR were significantly positively correlated with node efficiency of DLPFC (p < 0.05). CONCLUSIONS Our findings suggest that there were alternations in both central and peripheral parts of ANS in PCS patients. These preliminary results indicate that PCS may lead to changes in both the peripheral and central aspects of ANS, which would help to extend the understanding of the role of the ANS in PCS, offering new perspectives on evaluation and treatment. TRIAL REGISTRATION This study has been registered with the Chinese Clinical Trial Registration Center (registration number: ChiCTR2200064342; registration date:2022/10/3).
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Affiliation(s)
- Jia-Yin Ma
- Center of Rehabilitation Medicine, Yueyang Hospital of integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
| | - Jia-Jia Wu
- Center of Rehabilitation Medicine, Yueyang Hospital of integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China
| | - Yi Zhu
- Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Hand Reconstruction, Fudan University, Shanghai, China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China; Institute of Hand Surgery, Fudan University, Shanghai, China
| | - Mou-Xiong Zheng
- Department of Traumatology and Orthopedics, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China.
| | - Xu-Yun Hua
- Department of Traumatology and Orthopedics, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China.
| | - Jian-Guang Xu
- School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China; Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China.
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Chen Z, Zhao X, Liu H, Wang Y, Zhang Z, Zhang Y, Liu Y. Individualized post-operative prediction of cochlear implantation outcomes in children with prelingual deafness using functional near-infrared spectroscopy. Laryngoscope Investig Otolaryngol 2024; 9:e70035. [PMID: 39539355 PMCID: PMC11558700 DOI: 10.1002/lio2.70035] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2024] [Revised: 10/08/2024] [Accepted: 10/29/2024] [Indexed: 11/16/2024] Open
Abstract
Objective The goal of this study was to develop an objective measure and predictor of cochlear implantation (CI) outcomes using functional near-infrared spectroscopy (fNIRS) for young children with prelingual deafness. Methods Sound-evoked hemodynamic responses were recorded from auditory and language-related cortical regions of 47 child CI recipients (35.47 ± 17.24 months of age) using fNIRS shortly after CI activation (0.26 ± 0.30 months). There were four sound conditions (natural speech, instrumental music, multi-speaker babble noise, and speech-in-noise). Post-CI auditory and verbal communication performance was evaluated using clinical questionnaires with caretakers. Both classification and individualized regression models were constructed to predict post-CI behavioral improvement from fNIRS data using support vector machine (SVM) learning algorithms. Results Auditory cortical responses shortly after CI hearing onset yielded highly accurate prediction of behavioral development in young CI children. For classification models, optimal prediction was achieved using cortical responses to two or more sound conditions, with the highest accuracy of 98.20% (precision = 98.17%, sensitivity = 98.96%, area under the curve of the receiver operating characteristic curve = 99.61%) obtained with the combination of speech, noise, and music stimuli. Similarly, for regression models, best prediction of individual development was achieved using three (highest r = 0.919) or four (r = 0.966) sound conditions. The predictability of cortical responses far outperformed (Cohen's d: 18.56) that of the collection of audiological and demographic parameters (classification accuracy: 0.62) under the same SVM algorithms and could not benefit from the inclusion of the latter. Conclusion Machine learning models using auditory cortical hemodynamic responses shortly after CI activation were able to predict individualized post-CI behavioral improvement in children with prelingual deafness. Level of Evidence Level 5.
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Affiliation(s)
- Zhe Chen
- Department of Otorhinolaryngology Head and NeckBeijing Friendship Hospital, Capital Medical UniversityBeijingChina
| | - Xue Zhao
- State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijingChina
| | - Haotian Liu
- Department of Otolaryngology Head and Neck SurgeryWest China Hospital of Sichuan UniversityChengduChina
| | - Yuyang Wang
- Department of Otolaryngology Head and Neck SurgeryHunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal UniversityChangshaChina
| | - Zhikai Zhang
- Department of Otorhinolaryngology Head and NeckBeijing Chao‐Yang Hospital, Capital Medical UniversityBeijingChina
| | - Yuxuan Zhang
- State Key Laboratory of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijingChina
| | - Yuhe Liu
- Department of Otorhinolaryngology Head and NeckBeijing Friendship Hospital, Capital Medical UniversityBeijingChina
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Luo Y, Du J, Yu H, Fang F, Shi P. Resting-state fNIRS reveals changes in prefrontal cortex functional connectivity during TENS in patients with chronic pain. Sci Rep 2024; 14:29187. [PMID: 39587185 PMCID: PMC11589569 DOI: 10.1038/s41598-024-79820-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/14/2024] [Accepted: 11/12/2024] [Indexed: 11/27/2024] Open
Abstract
Transcutaneous electrical nerve stimulation (TENS) has been used to treat chronic pain. However, the potential efficacy and mechanism of the effect of applying TENS for a short time in chronic pain patients remains unclear. To identify the effect of short-term TENS on chronic pain patients and to clarify the mechanism of the effect, we investigated abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) using resting-state functional near-infrared spectroscopy (rs-fNIRS). Fifteen patients (56.8 ± 17.4 years, nine females) with chronic pain participated in this rs-fNIRS study. The fNIRS scans included two parts: a 5-minute resting-state scan followed by a 5-minute scan during TENS (150 Hz) application. The pain intensity was measured using a Visual Analog Scale (VAS) and Pittsburgh Sleep Quality Index (PSQI). The spontaneous brain activity of the PFC and resting-state functional connectivity (rsFC) in the PFC were examined during TENS and compared to before TENS. The results showed that Pain intensity significantly decreased after TENS (p < 0.001). During TENS, fALFF values were significantly lower in BA46 (**p = 0.0025) and BA45 (**p = 0.0056). rsFC strength increased during TENS compared to before, with significant group-level increases in BA10, BA9, BA46, and BA44/45 (p < 0.05). Notably, the variation between BA10 and BA44/45 was highly significant (***p < 0.001). These findings suggest that FC between BA10 and BA44/45 was associated with analgesia of TENS in patients with chronic pain, indicating the potential role of FC as a novel objective parameter to predict the outcome of clinical use of TENS for pain relief in chronic pain patients.
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Affiliation(s)
- Yijing Luo
- School of Health Sciences and Engineering, University of Shanghai for Science and Technology, NO. 516, Jungong Road, Yangpu District, Shanghai, 200093, China
| | - Jiahao Du
- School of Health Sciences and Engineering, University of Shanghai for Science and Technology, NO. 516, Jungong Road, Yangpu District, Shanghai, 200093, China
| | - Hongliu Yu
- School of Health Sciences and Engineering, University of Shanghai for Science and Technology, NO. 516, Jungong Road, Yangpu District, Shanghai, 200093, China
| | - Fanfu Fang
- Department of Rehabilitation Medicine, the First Affiliated Hospital of the Naval Medical University, Shanghai, 200433, China
| | - Ping Shi
- School of Health Sciences and Engineering, University of Shanghai for Science and Technology, NO. 516, Jungong Road, Yangpu District, Shanghai, 200093, China.
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Leong C, Zhao Z, Yuan Z, Liu B. Distinct brain network organizations between club players and novices under different difficulty levels. Brain Behav 2024; 14:e3488. [PMID: 38641879 PMCID: PMC11031636 DOI: 10.1002/brb3.3488] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/02/2023] [Revised: 03/17/2024] [Accepted: 03/31/2024] [Indexed: 04/21/2024] Open
Abstract
SIGNIFICANT Chunk memory is one of the essential cognitive functions for high-expertise (HE) player to make efficient decisions. However, it remains unknown how the neural mechanisms of chunk memory processes mediate or alter chess players' performance when facing different opponents. AIM This study aimed at inspecting the significant brain networks associated with chunk memory, which would vary between club players and novices. APPROACH Functional networks and topological features of 20 club players (HE) and 20 novice players (LE) were compared at different levels of difficulty by means of functional near-infrared spectroscopy. RESULTS Behavioral performance indicated that the club player group was unaffected by differences in difficulty. Furthermore, the club player group demonstrated functional connectivity among the dorsolateral prefrontal cortex, the frontopolar cortex, the supramarginal gyrus, and the subcentral gyrus, as well as higher clustering coefficients and lower path lengths in the high-difficulty task. CONCLUSIONS The club player group illustrated significant frontal-parietal functional connectivity patterns and topological characteristics, suggesting enhanced chunking processes for improved chess performance.
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Affiliation(s)
- Chantat Leong
- Centre for Cognitive and Brain SciencesUniversity of MacauMacau SARChina
- Faculty of Health SciencesUniversity of MacauMacau SARChina
| | - Zhiying Zhao
- Centre for Cognitive and Brain SciencesUniversity of MacauMacau SARChina
| | - Zhen Yuan
- Centre for Cognitive and Brain SciencesUniversity of MacauMacau SARChina
- Faculty of Health SciencesUniversity of MacauMacau SARChina
| | - Bin Liu
- Department of EmergencyZhujiang Hospital, Southern Medical UniversityGuangzhouChina
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Deng H, Liao L, Wu J, Wan L. Intravesical Electrical Stimulation Improves Abnormal Prefrontal Brain Activity in Patients With Underactive Bladder: A Possible Central Mechanism. Int Neurourol J 2023; 27:260-270. [PMID: 38171326 PMCID: PMC10762371 DOI: 10.5213/inj.2346232.116] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/19/2023] [Accepted: 11/11/2023] [Indexed: 01/05/2024] Open
Abstract
PURPOSE The aim of this study was to explore the mechanisms of central brain action in patients with neurogenic underactive bladder (UAB) treated with intravesical electrical stimulation (IVES). METHODS We prospectively recruited patients with neurogenic UAB who chose to receive IVES treatment and healthy subjects (HS). At baseline, the following data were obtained: a 72-hour voiding diary; measurements of postvoid residual urine (PVR), voiding efficiency (VE) and first sensation of bladder filling (FS); American Urological Association Symptom Index Quality of Life (AUA-SI-QOL) scores, and functional near-infrared spectroscopy scans of the prefrontal cortex in the voiding stage. All UAB patients were re-evaluated for these indices after completing 4 weeks of IVES. A >50% improvement in PVR was defined as successful IVES treatment. Prefrontal activity was analyzed using the NIRS_KIT software, corrected with the false discovery rate (P<0.05). Statistical analysis was performed using IBM SPSS Statistics ver. 22.0, and P<0.05 was considered statistically significant. RESULTS Eighteen UAB patients and 16 HS were included. IVES treatment was successful in 11 UAB patients and failed in 7. The PVR, VE, 24-hour clean intermittent catheterization, FS volume, and AUA-SI-QOL scores of the UAB group significantly improved after successful IVES treatment. BA9 (right dorsolateral prefrontal cortex [DLPFC]) and BA10 (right frontal pole) were significantly activated after successful IVES, and no significant difference was found between the successful group and HS group after IVES. Before IVES, BA10 (right frontal pole) was significantly deactivated in the failed group compared with the successful group. CONCLUSION The possible central mechanism of IVES treatment for neurogenic UAB is that IVES reactivates the right DLPFC and right frontal pole.
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Affiliation(s)
- Han Deng
- Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, Beijing, China
| | - Limin Liao
- Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, Beijing, China
- China Rehabilitation Science Institute, Beijing, China
- University of Health and Rehabilitation Sciences, Qingdao, China
- Cheeloo College of Medicine, Shandong University, Jinan, China
- Wenzhou Medical University, Wenzhou, China
| | - Juan Wu
- Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, Beijing, China
| | - Li Wan
- Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, Beijing, China
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Zeng X, Tang W, Yang J, Lin X, Du M, Chen X, Yuan Z, Zhang Z, Chen Z. Diagnosis of Chronic Musculoskeletal Pain by Using Functional Near-Infrared Spectroscopy and Machine Learning. Bioengineering (Basel) 2023; 10:669. [PMID: 37370599 DOI: 10.3390/bioengineering10060669] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/12/2023] [Revised: 05/10/2023] [Accepted: 05/15/2023] [Indexed: 06/29/2023] Open
Abstract
Chronic pain (CP) has been found to cause significant alternations of the brain's structure and function due to changes in pain processing and disrupted cognitive functions, including with respect to the prefrontal cortex (PFC). However, until now, no studies have used a wearable, low-cost neuroimaging tool capable of performing functional near-infrared spectroscopy (fNIRS) to explore the functional alternations of the PFC and thus automatically achieve a clinical diagnosis of CP. In this case-control study, the pain characteristics of 19 chronic pain patients and 32 healthy controls were measured using fNIRS. Functional connectivity (FC), FC in the PFC, and spontaneous brain activity of the PFC were examined in the CP patients and compared to those of healthy controls (HCs). Then, leave-one-out cross-validation and machine learning algorithms were used to automatically achieve a diagnosis corresponding to a CP patient or an HC. The current study found significantly weaker FC, notably higher small-worldness properties of FC, and increased spontaneous brain activity during resting state within the PFC. Additionally, the resting-state fNIRS measurements exhibited excellent performance in identifying the chronic pain patients via supervised machine learning, achieving F1 score of 0.8229 using only seven features. It is expected that potential FC features can be identified, which can thus serve as a neural marker for the detection of CP using machine learning algorithms. Therefore, the present study will open a new avenue for the diagnosis of chronic musculoskeletal pain by using fNIRS and machine learning techniques.
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Affiliation(s)
- Xinglin Zeng
- Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang 421000, China
- Faculty of Health Sciences, University of Macau, Macau SAR, China
- Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, China
| | - Wen Tang
- Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China
| | - Jiajia Yang
- Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China
| | - Xiange Lin
- Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China
| | - Meng Du
- Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang 421000, China
| | - Xueli Chen
- School of Life Science and Technology, Xidian University, 266 Xinglong Section of Xifeng Road, Xi'an 710126, China
| | - Zhen Yuan
- Faculty of Health Sciences, University of Macau, Macau SAR, China
- Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, China
| | - Zhou Zhang
- Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China
| | - Zhiyi Chen
- Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang 421000, China
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11
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Li X, Fang R, Liao L, Li X. Real-time changes in brain activity during tibial nerve stimulation for overactive bladder: Evidence from functional near-infrared spectroscopy hype scanning. Front Neurosci 2023; 17:1115433. [PMID: 37090808 PMCID: PMC10113489 DOI: 10.3389/fnins.2023.1115433] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2022] [Accepted: 03/17/2023] [Indexed: 04/07/2023] Open
Abstract
Purpose To use functional near-infrared spectroscopy (fNIRS) to identify changes in brain activity during tibial nerve stimulation (TNS) in patients with overactive bladder (OAB) responsive to therapy. Methods Eighteen patients with refractory idiopathic OAB patients were recruited consecutively for this pilot study. At baseline, all patients completed 3 days voiding diary, Quality-of-Life score, Perception-of-Bladder-Condition, and Overactive-Bladder-Symptom score. Then 4 region-of-interest (ROI) fNIRS scans with 3 blocks were conducted for each patient. The block design was used: 60 s each for the task and rest periods and 3 to 5 repetitions of each period. A total of 360 s of data were collected. During the task period, patients used transcutaneous tibial nerve stimulation (TTNS) of 20-Hz frequency and a 0.2-millisecond pulse width and 30-milliamp stimulatory current to complete the experiment. The initial scan was obtained with a sham stimulation with an empty bladder, and a second was obtained with a verum stimulation with an empty bladder. Patients were given water till strong desire to void, and the third fNIRS scan with a verum stimulation was performed. The patients then needed to urinate since they could not tolerate the SDV condition for a long time. After a period of rest, the patients then were given water until they exhibited SDV state. The fourth scan with sham fNIRS scan in the SDV state was performed. NIRS_KIT software was used to analyze prefrontal activity, corrected by false discovery rate (FDR, p < 0.05). Statistical analyses were performed using GraphPad Prism software; p < 0.05 was considered significant. Results TTNS treatment was successful in 16 OAB patients and unsuccessful in 2. The 3 days voiding diary, Quality-of-Life score, Perception-of-Bladder-Condition, and Overactive-Bladder-Symptom score were significantly improved after TNS in the successfully treated group but not in the unsuccessfully treated group. The dorsolateral prefrontal cortex (DLPFC) (BA 9, Chapters 25 and 26) and the frontopolar area (FA) (BA 10, Chapters 35, 45, and 46) were significantly activated during TNS treatment with an empty bladder rather than with an SDV. Compared with the successfully treated group, the unsuccessfully treated group did not achieve statistical significance with an empty bladder and an SDV state. Conclusion fNIRS confirms that TNS influences brain activity in patients with OAB who respond to therapy. That may be the central mechanism of action of TNS.
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Affiliation(s)
- Xunhua Li
- Department of Urology, China Rehabilitation Research Center, School of Rehabilitation, Capital Medical University, Beijing, China
- University of Health and Rehabilitation Sciences, Qingdao, China
| | - Rui Fang
- Department of Occupational Therapy, China Rehabilitation Research Center, Beijing, China
| | - Limin Liao
- Department of Urology, China Rehabilitation Research Center, School of Rehabilitation, Capital Medical University, Beijing, China
- University of Health and Rehabilitation Sciences, Qingdao, China
- China Rehabilitation Science Institute, Beijing, China
| | - Xing Li
- Department of Urology, China Rehabilitation Research Center, School of Rehabilitation, Capital Medical University, Beijing, China
- University of Health and Rehabilitation Sciences, Qingdao, China
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12
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Niu B, Li Y, Ding X, Shi C, Zhou B, Gong J. Neural correlates of bribe-taking decision dilemma: An fNIRS study. Brain Cogn 2023; 166:105951. [PMID: 36680856 DOI: 10.1016/j.bandc.2023.105951] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2022] [Revised: 01/04/2023] [Accepted: 01/05/2023] [Indexed: 01/21/2023]
Abstract
Bribe-taking decision is a social dilemma for individuals: the pursuit of economic self-interest vs. compliance with social norms. Despite the well-known existence of the conflict in deciding whether to accept bribes, little is known about its neural responses. Using functional near-infrared imaging (fNIRS) technology and the bribe-taking decision game (economic gambling game as a control condition), the current study dissociated the neural correlates of the different motivations in the bribery dilemma, as well as the inhibitory effect of social norms on bribery and its underlying brain mechanisms in supra-cortical regions. Findings revealed that if individuals are more motivated by economic interest, rejecting money (vs. accepting money) accompanies higher activity in the dorsolateral prefrontal cortex (DLPFC) and frontopolar cortex (FPC), which reflects impulse inhibition and decision evaluation; whereas, if individuals are more consider social norms, their DLPFC is more active when they accept bribes (vs. reject bribes), which reflects their fear of punishment. Additionally, the key brain region where social norms inhibit bribery involves the left DLPFC. The current findings contribute to the literature on the neural manifestations of corrupt decisions and provide some insights into the anti-corruption movement.
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Affiliation(s)
- Bingyu Niu
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China
| | - Ye Li
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
| | - Xianfeng Ding
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
| | - Congrong Shi
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China
| | - Bingping Zhou
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China
| | - Jian Gong
- School of Psychology, Central China Normal University, No. 152 Luoyu Street, Hongshan District, Wuhan 430079, Hubei, China; Key Laboratory of Adolescent Cyber Psychology and Behavior (CCNU), Ministry of Education, Wuhan, China
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13
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Chen H, Miao G, Wang S, Zheng J, Zhang X, Lin J, Hao C, Huang H, Jiang T, Gong Y, Liao W. Disturbed functional connectivity and topological properties of the frontal lobe in minimally conscious state based on resting-state fNIRS. Front Neurosci 2023; 17:1118395. [PMID: 36845431 PMCID: PMC9950516 DOI: 10.3389/fnins.2023.1118395] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2022] [Accepted: 01/30/2023] [Indexed: 02/12/2023] Open
Abstract
Background Patients in minimally conscious state (MCS) exist measurable evidence of consciousness. The frontal lobe is a crucial part of the brain that encodes abstract information and is closely related to the conscious state. We hypothesized that the disturbance of the frontal functional network exists in MCS patients. Methods We collected the resting-state functional near-infrared spectroscopy (fNIRS) data of fifteen MCS patients and sixteen age- and gender-matched healthy controls (HC). The Coma Recovery Scale-Revised (CRS-R) scale of MCS patients was also composed. The topology of the frontal functional network was analyzed in two groups. Results Compared with HC, the MCS patients showed widely disrupted functional connectivity in the frontal lobe, especially in the frontopolar area and right dorsolateral prefrontal cortex. Moreover, the MCS patients displayed lower clustering coefficient, global efficiency, local efficiency, and higher characteristic path length. In addition, the nodal clustering coefficient and nodal local efficiency in the left frontopolar area and right dorsolateral prefrontal cortex were significantly reduced in MCS patients. Furthermore, the nodal clustering coefficient and nodal local efficiency in the right dorsolateral prefrontal cortex were positively correlated to auditory subscale scores. Conclusion This study reveals that MCS patients' frontal functional network is synergistically dysfunctional. And the balance between information separation and integration in the frontal lobe is broken, especially the local information transmission in the prefrontal cortex. These findings help us to understand the pathological mechanism of MCS patients better.
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Affiliation(s)
| | | | - Sirui Wang
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Jun Zheng
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Xin Zhang
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Junbin Lin
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Chizi Hao
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Hailong Huang
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
| | - Ting Jiang
- Department of Rehabilitation Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
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How the brain encodes morphological constraints during Chinese word reading: An EEG-fNIRS study. Cortex 2022; 154:184-196. [DOI: 10.1016/j.cortex.2022.05.016] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2021] [Revised: 07/13/2021] [Accepted: 05/25/2022] [Indexed: 11/19/2022]
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15
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Tian F, Li H, Tian S, Tian C, Shao J. Is There a Difference in Brain Functional Connectivity between Chinese Coal Mine Workers Who Have Engaged in Unsafe Behavior and Those Who Have Not? INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19010509. [PMID: 35010769 PMCID: PMC8744879 DOI: 10.3390/ijerph19010509] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/21/2021] [Revised: 12/27/2021] [Accepted: 12/27/2021] [Indexed: 12/31/2022]
Abstract
(1) Background: As a world-recognized high-risk occupation, coal mine workers need various cognitive functions to process the surrounding information to cope with a large number of perceived hazards or risks. Therefore, it is necessary to explore the connection between coal mine workers’ neural activity and unsafe behavior from the perspective of cognitive neuroscience. This study explored the functional brain connectivity of coal mine workers who have engaged in unsafe behaviors (EUB) and those who have not (NUB). (2) Methods: Based on functional near-infrared spectroscopy (fNIRS), a total of 106 workers from the Hongliulin coal mine of Shaanxi North Mining Group, one of the largest modern coal mines in China, completed the test. Pearson’s Correlation Coefficient (COR) analysis, brain network analysis, and two-sample t-test were used to investigate the difference in brain functional connectivity between the two groups. (3) Results: The results showed that there were significant differences in functional brain connectivity between EUB and NUB among the frontopolar area (p = 0.002325), orbitofrontal area (p = 0.02102), and pars triangularis Broca’s area (p = 0.02888). Small-world properties existed in the brain networks of both groups, and the dorsolateral prefrontal cortex had significant differences in clustering coefficient (p = 0.0004), nodal efficiency (p = 0.0384), and nodal local efficiency (p = 0.0004). (4) Conclusions: This study is the first application of fNIRS to the field of coal mine safety. The fNIRS brain functional connectivity analysis is a feasible method to investigate the neuropsychological mechanism of unsafe behavior in coal mine workers in the view of brain science.
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Affiliation(s)
- Fangyuan Tian
- Institute of Safety Management & Risk Control, Institute of Safety & Emergency Management, School of Safety Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China; (F.T.); (S.T.); (C.T.)
| | - Hongxia Li
- Institute of Safety Management & Risk Control, Institute of Safety & Emergency Management, School of Safety Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China; (F.T.); (S.T.); (C.T.)
- School of Management, Xi’an University of Science and Technology, Xi’an 710054, China
- Correspondence: ; Tel.: +86-152-9159-9962
| | - Shuicheng Tian
- Institute of Safety Management & Risk Control, Institute of Safety & Emergency Management, School of Safety Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China; (F.T.); (S.T.); (C.T.)
| | - Chenning Tian
- Institute of Safety Management & Risk Control, Institute of Safety & Emergency Management, School of Safety Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China; (F.T.); (S.T.); (C.T.)
| | - Jiang Shao
- School of Architecture & Design, China University of Mining and Technology, Xuzhou 221116, China;
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16
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Qiu S, Mei G. Spontaneous recovery of adaptation aftereffects of natural facial categories. Vision Res 2021; 188:202-210. [PMID: 34365177 DOI: 10.1016/j.visres.2021.07.015] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2021] [Revised: 07/07/2021] [Accepted: 07/23/2021] [Indexed: 10/20/2022]
Abstract
Adaptation to a natural face attribute such as a happy face can bias the perception of a subsequent face in this dimension such as a neutral face. Such face adaptation aftereffects have been widely found in many natural facial categories. However, how temporally tuned mechanisms could control the temporal dynamics of natural face adaptation aftereffects remains unknown. To address the question, we used a deadaptation paradigm to examine whether the spontaneous recovery of natural facial aftereffects would emerge in four natural facial categories including variable categories (emotional expressions in Experiment 1 and eye gaze in Experiment 2) and invariable categories (facial gender in Experiment 3 and facial identity in Experiment 4). In the deadaptation paradigm, participants adapted to a face with an extreme attribute (such as a 100% angry face in Experiment 1) for a relatively long duration, and then deadapted to a face with an opposite extreme attribute (such as a 100% happy face in Experiment 1) for a relatively short duration. The time courses of face adaptation aftereffects were measured using a top-up manner. Deadaptation only masked the effects of initial longer-lasting adaptation, and the spontaneous recovery of adaptation aftereffects was observed at the post-test stage for all four natural facial categories. These results likely indicate that the temporal dynamics of adaptation aftereffects of natural facial categories may be controlled by multiple temporally tuned mechanisms.
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Affiliation(s)
- Shiming Qiu
- School of Psychology, Guizhou Normal University, Guiyang, PR China
| | - Gaoxing Mei
- School of Psychology, Guizhou Normal University, Guiyang, PR China.
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17
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Pang D, Liao L. Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis/bladder pain syndrome (IC/BPS): A pilot study using resting state functional near-infrared spectroscopy (rs-fNIRS). Neurourol Urodyn 2021; 40:1634-1642. [PMID: 34130350 DOI: 10.1002/nau.24729] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2021] [Revised: 05/16/2021] [Accepted: 05/25/2021] [Indexed: 12/30/2022]
Abstract
PURPOSE To investigate the abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) based on resting state functional near-infrared spectroscopy (rs-fNIRS) data using FC matrix analysis. MATERIALS AND METHODS Ten patients with IC/BPS (females, 9; mean age, 56.9 ± 12.432 years) and 15 age- and gender-matched healthy controls (HC) (females, 12; mean age, 55.067 ± 7.46 years) participated in this rs-fNIRS study. Two rs-fNIRS scans were performed (when the bladder was empty and when the desire to void was strong). The Pearson's correlation coefficient between the time series of the 22 channels was calculated to obtain a 22 × 22 FC matrix for each subject. A two-sample t-test (p < .05) was performed to compare group differences in the FC matrix between patients with IC/BPS and HC. RESULTS FC was significantly decreased within the PFC in the IC/BPS group based on a two-sample t-test (p < .05) compared with HC. FC decreased in a wider range of brain regions during the strong desire to void state (4 brain regions and 28 edges) when compared with the empty bladder state (3 brain regions and 18 edges). CONCLUSION FC abnormalities in IC/BPS patients may lead to frontal lobe disorders involved in processing sensory integration, motivation drive, emotional control, and decision-making whether to urinate, leading to urinary control dysfunction manifested as typical clinical IC/BPS symptoms. Our results may provide new insight into the pathogenesis of IC/BPS and new brain biomarkers for diagnosis.
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Affiliation(s)
- Dongqing Pang
- School of Rehabilitation, Capital Medical University, Beijing, China.,Department of Urology, China Rehabilitation Research Centre, Beijing, China.,Department of Urology, Capital Medical University, Beijing, China
| | - Limin Liao
- School of Rehabilitation, Capital Medical University, Beijing, China.,Department of Urology, China Rehabilitation Research Centre, Beijing, China.,Department of Urology, Capital Medical University, Beijing, China
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18
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Lin XA, Wang C, Zhou J, Sai L, Fu G. Neural correlates of spontaneous deception in a non-competitive interpersonal scenario: A functional near-infrared spectroscopy (fNIRS) study. Brain Cogn 2021; 150:105704. [PMID: 33640738 DOI: 10.1016/j.bandc.2021.105704] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2020] [Revised: 11/07/2020] [Accepted: 02/05/2021] [Indexed: 01/10/2023]
Abstract
This study aims to examine neural correlates of spontaneous deception in a non-competitive interpersonal situation, and the difference in neural correlates between spontaneous deception and instructed deception using functional near-infrared spectroscopy (fNIRS). We used a modified poker game in which participants freely decided whether sending a piece of truthful/deceptive information to other participants. In the instructed session, participants sent truthful/deceptive information per the instructions. In this non-competitive interpersonal situation in the orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC), deception produced higher neural activities than truth-telling. In addition, spontaneous deception exhibited higher neural activities than instructed deception in the frontopolar area, DLPFC, and frontal eye fields. Spontaneous truth-telling produced higher neural activities than instructed truth-telling in frontal eye fields and frontopolar area. This study provides evidence about neural correlates of spontaneous deception during non-competitive interpersonal scenarios and the difference between spontaneous deception and instructed deception.
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Affiliation(s)
- Xiaohong Allison Lin
- Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China.
| | - Chongxiang Wang
- Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China
| | - Jie Zhou
- Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China
| | - Liyang Sai
- Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China
| | - Genyue Fu
- Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, China; Department of Psychology, Zhejiang Normal University, Jinhua, China.
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19
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Li C, Ding K, Zhang M, Zhang L, Zhou J, Yu D. Effect of Picture-Book Reading With Additive Audio on Bilingual Preschoolers' Prefrontal Activation: A Naturalistic Functional Near-Infrared Spectroscopy Study. Front Psychol 2020; 11:1939. [PMID: 32849138 PMCID: PMC7419625 DOI: 10.3389/fpsyg.2020.01939] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2020] [Accepted: 07/13/2020] [Indexed: 12/21/2022] Open
Abstract
Acquiring a second language (L2) has the power to shape cognition and even the function and structure of the brain. Picture-book reading with additive audio (PRA) is a popular and convenient means of providing L2 exposure for non-balanced bilingual children; however, its contribution to bilingual children’s brain activity is unclear. This study conducted a rigorous bilingual word comprehension experiment and a naturalistic PRA task to explore the effect of L2 processing on brain activation among English as a foreign language (EFL) preschoolers, using functional near-infrared spectroscopy (fNIRS). We found that the two contexts of comprehending English words and bilingual switching (BS), which impose more cognitive control demands, activated the prefrontal cortex (PFC) more than did the condition of comprehending Chinese words. Furthermore, the effect of PFC activity in the condition of picture-book reading with additive English audio (English PRA) was also found to be greater than in the condition of picture-book reading with additive Chinese audio (Chinese PRA); moreover, the effect was modulated by story difficulty. Finally, a positive correlation was shown between EFL children’s English competence and PFC activation through English PRA. This study indicates that the experiences of hearing L2 auditory stories in a picture-book reading activity yielded significant changes to early bilinguals’ PFC functional for cognitive control and language processing.
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Affiliation(s)
- Chuanjiang Li
- Key Laboratory of Child Development and Learning Science of Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, China
| | - Keya Ding
- Key Laboratory of Child Development and Learning Science of Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, China
| | - Mingming Zhang
- School of Psychology, Shanghai Normal University, Shanghai, China
| | - Li Zhang
- Faculty of Education, East China Normal University, Shanghai, China
| | - Jing Zhou
- Faculty of Education, East China Normal University, Shanghai, China
| | - Dongchuan Yu
- Key Laboratory of Child Development and Learning Science of Ministry of Education, Research Center for Learning Science, Southeast University, Nanjing, China
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Xu SY, Lu FM, Wang MY, Hu ZS, Zhang J, Chen ZY, Armada-da-Silva PAS, Yuan Z. Altered Functional Connectivity in the Motor and Prefrontal Cortex for Children With Down's Syndrome: An fNIRS Study. Front Hum Neurosci 2020; 14:6. [PMID: 32116599 PMCID: PMC7034312 DOI: 10.3389/fnhum.2020.00006] [Citation(s) in RCA: 33] [Impact Index Per Article: 6.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2019] [Accepted: 01/09/2020] [Indexed: 11/14/2022] Open
Abstract
Children with Down's syndrome (DS) might exhibit disrupted brain functional connectivity in the motor and prefrontal cortex. To inspect the alterations in brain activation and functional connectivity for children with DS, the functional near-infrared spectroscopy (fNIRS) method was applied to examine the brain activation difference in the motor and prefrontal cortex between the DS and typically developing (TD) groups during a fine motor task. In addition, small-world analysis based on graph theory was also carried out to characterize the topological organization of functional brain networks. Interestingly, behavior data demonstrated that the DS group showed significantly long reaction time and low accuracy as compared to the TD group (p < 0.05). More importantly, significantly reduced brain activations in the frontopolar area, the pre-motor, and the supplementary motor cortex (p < 0.05) were identified in the DS group compared with the TD group. Meanwhile, significantly high global efficiency (E g ) and short average path length (L p ) were also detected for the DS group. This pilot study illustrated that the disrupted connectivity of frontopolar area, pre-motor, and supplementary motor cortex might be one of the core mechanisms associated with motor and cognitive impairments for children with DS. Therefore, the combination of the fNIRS technique with functional network analysis may pave a new avenue for improving our understanding of the neural mechanisms of DS.
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Affiliation(s)
- Shi-Yang Xu
- Faculty of Health Sciences, University of Macau, Macau, China
- Centre for Cognitive and Brain Sciences, University of Macau, Macau, China
| | - Feng-Mei Lu
- Faculty of Health Sciences, University of Macau, Macau, China
- MOE Key Laboratory for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China
| | - Meng-Yun Wang
- Faculty of Health Sciences, University of Macau, Macau, China
| | - Zhi-Shan Hu
- Faculty of Health Sciences, University of Macau, Macau, China
| | - Juan Zhang
- Faculty of Education, University of Macau, Macau, China
| | - Zhi-Yi Chen
- Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
| | - Paulo A. S. Armada-da-Silva
- Faculty of Human Kinetics, University of Lisbon, Cruz Quebrada, Portugal
- Neuromechanics of Human Movement, Faculty of Human Kinetics, CIPER, University of Lisbon, Lisbon, Portugal
| | - Zhen Yuan
- Faculty of Health Sciences, University of Macau, Macau, China
- Centre for Cognitive and Brain Sciences, University of Macau, Macau, China
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Hu Z, Zhang J, Couto TA, Xu S, Luan P, Yuan Z. Optical Mapping of Brain Activation and Connectivity in Occipitotemporal Cortex During Chinese Character Recognition. Brain Topogr 2018; 31:1014-1028. [PMID: 29934729 DOI: 10.1007/s10548-018-0650-y] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2017] [Accepted: 05/17/2018] [Indexed: 12/14/2022]
Abstract
In this study, functional near-infrared spectroscopy (fNIRS) was used to examine the brain activation and connectivity in occipitotemporal cortex during Chinese character recognition (CCR). Eighteen healthy participants were recruited to perform a well-designed task with three categories of stimuli (real characters, pseudo characters, and checkerboards). By inspecting the brain activation difference and its relationship with behavioral data, the left laterality during CCR was clearly identified in the Brodmann area (BA) 18 and 19. In addition, our novel findings also demonstrated that the bilateral superior temporal gyrus (STG), bilateral BA 19, and left fusiform gyrus were also involved in high-level lexical information processing such as semantic and phonological ones. Meanwhile, by examining functional brain networks, we discovered that the right BA 19 exhibited enhanced brain connectivity. In particular, the connectivity in the right fusiform gyrus, right BA 19, and left STG showed significant correlation with the performance of CCR. Consequently, the combination of fNIRS technique with functional network analysis paves a new avenue for improved understanding of the cognitive mechanism underlying CCR.
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Affiliation(s)
- Zhishan Hu
- Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau, SAR, China
| | - Juan Zhang
- Faculty of Education, University of Macau, Macau, SAR, China.
| | | | - Shiyang Xu
- Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau, SAR, China
| | - Ping Luan
- Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China
| | - Zhen Yuan
- Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau, SAR, China.
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Huang J, He X, Ma X, Ren Y, Zhao T, Zeng X, Li H, Chen Y. Sequential biases on subjective judgments: Evidence from face attractiveness and ringtone agreeableness judgment. PLoS One 2018; 13:e0198723. [PMID: 29889850 PMCID: PMC5995378 DOI: 10.1371/journal.pone.0198723] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/08/2017] [Accepted: 05/24/2018] [Indexed: 11/19/2022] Open
Abstract
When people make decisions about sequentially presented items in psychophysical experiments, their decisions are always biased by their preceding decisions and the preceding items, either by assimilation (shift towards the decision or item) or contrast (shift away from the decision or item). Such sequential biases also occur in naturalistic and real-world judgments such as facial attractiveness judgments. In this article, we aimed to cast light on the causes of these sequential biases. We first found significant assimilative and contrastive effects in a visual face attractiveness judgment task and an auditory ringtone agreeableness judgment task, indicating that sequential effects are not limited to the visual modality. We then found that the provision of trial-by-trial feedback of the preceding stimulus value eliminated the contrastive effect, but only weakened the assimilative effect. When participants orally reported their judgments rather than indicated them via a keyboard button press, we found a significant diminished assimilative effect, suggesting that motor response repetition strengthened the assimilation bias. Finally, we found that when visual and auditory stimuli were alternated, there was no longer a contrastive effect from the immediately previous trial, but there was an assimilative effect both from the previous trial (cross-modal) and the 2-back trial (same stimulus modality). These findings suggested that the contrastive effect results from perceptual processing, while the assimilative effect results from anchoring of the previous judgment and is strengthened by response repetition and numerical priming.
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Affiliation(s)
- Jianrui Huang
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Xianyou He
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
- * E-mail:
| | - Xiaojin Ma
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Yian Ren
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Tingting Zhao
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Xin Zeng
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Han Li
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
| | - Yiheng Chen
- Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, School of Psychology, South China Normal University, Guangzhou, China
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Sander TH, Zhou B. Linking neuroimaging signals to behavioral responses in single cases: Challenges and opportunities. Psych J 2016; 5:161-9. [DOI: 10.1002/pchj.143] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2016] [Revised: 08/09/2016] [Accepted: 08/09/2016] [Indexed: 11/08/2022]
Affiliation(s)
| | - Bin Zhou
- Key Laboratory of Behavioral Sciences, Institute of Psychology; Chinese Academy of Sciences; Beijing China
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Short LA, Proietti V, Mondloch CJ. Representing young and older adult faces: Shared or age-specific prototypes? VISUAL COGNITION 2015. [DOI: 10.1080/13506285.2015.1115794] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022]
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Yücel MA, Selb J, Aasted CM, Petkov MP, Becerra L, Borsook D, Boas DA. Short separation regression improves statistical significance and better localizes the hemodynamic response obtained by near-infrared spectroscopy for tasks with differing autonomic responses. NEUROPHOTONICS 2015; 2:035005. [PMID: 26835480 PMCID: PMC4717232 DOI: 10.1117/1.nph.2.3.035005] [Citation(s) in RCA: 92] [Impact Index Per Article: 9.2] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/06/2015] [Accepted: 08/10/2015] [Indexed: 05/07/2023]
Abstract
Autonomic nervous system response is known to be highly task-dependent. The sensitivity of near-infrared spectroscopy (NIRS) measurements to superficial layers, particularly to the scalp, makes it highly susceptible to systemic physiological changes. Thus, one critical step in NIRS data processing is to remove the contribution of superficial layers to the NIRS signal and to obtain the actual brain response. This can be achieved using short separation channels that are sensitive only to the hemodynamics in the scalp. We investigated the contribution of hemodynamic fluctuations due to autonomous nervous system activation during various tasks. Our results provide clear demonstrations of the critical role of using short separation channels in NIRS measurements to disentangle differing autonomic responses from the brain activation signal of interest.
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Affiliation(s)
- Meryem A. Yücel
- Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States
- Address all correspondence to: Meryem A. Yücel, E-mail:
| | - Juliette Selb
- Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States
| | - Christopher M. Aasted
- Boston Children’s Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
| | - Mike P. Petkov
- Boston Children’s Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
| | - Lino Becerra
- Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States
- Boston Children’s Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
- Harvard Medical School, Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
| | - David Borsook
- Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States
- Boston Children’s Hospital, Center for Pain and the Brain, Departments of Anaesthesia and Radiology, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
- Harvard Medical School, Department of Anesthesiology, Perioperative, and Pain Medicine, 300 Longwood Avenue, Boston, Massachusetts 02115, United States
| | - David A. Boas
- Massachusetts General Hospital, Harvard Medical School, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 149 13th Street, Charlestown, Massachusetts 02129, United States
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Boas DA, Elwell CE, Ferrari M, Taga G. Twenty years of functional near-infrared spectroscopy: introduction for the special issue. Neuroimage 2014; 85 Pt 1:1-5. [PMID: 24321364 DOI: 10.1016/j.neuroimage.2013.11.033] [Citation(s) in RCA: 332] [Impact Index Per Article: 30.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/22/2013] [Accepted: 06/03/2013] [Indexed: 10/25/2022] Open
Abstract
Papers from four different groups were published in 1993 demonstrating the ability of functional near infrared spectroscopy (fNIRS) to non-invasively measure hemoglobin concentration responses to brain function in humans. This special issue commemorates the first 20years of fNIRS research. The 9 reviews and 49 contributed papers provide a comprehensive survey of the exciting advances driving the field forward and of the myriad of applications that will benefit from fNIRS.
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Affiliation(s)
- David A Boas
- Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, USA
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