©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia
Shaun Hopper, Madhara Udawela, Elizabeth Scarr, Brian Dean, the Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Melbourne, Victoria 3052, Australia
Elizabeth Scarr, Brian Dean, Department of Psychiatry, the University of Melbourne, Melbourne, Victoria 3052, Australia
Author contributions: Hopper S, Udawela M, Scarr E and Dean B contributed to this paper.
Conflict-of-interest statement: There are no competing financial interests in relation to the work described in this paper. The authors report no competing interests.
Correspondence to: Shaun Hopper, MSc, the Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Gate 11 Royal Parade, Melbourne, Victoria 3052, Australia. shaun.hopper@florey.edu.au
Telephone: +61-90-356475
Received: September 19, 2015
Peer-review started: September 22, 2015
First decision: October 30, 2015
Revised: November 26, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 9, 2016
Processing time: 166 Days and 23.3 Hours
Peer-review started: September 22, 2015
First decision: October 30, 2015
Revised: November 26, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 9, 2016
Processing time: 166 Days and 23.3 Hours
Core Tip
Core tip: Schizophrenia is a psychiatric disorder affecting approximately 1% of the world population. Current treatments inadequately redress the cognitive impairments associated with the disease. In light of that we discuss the role of the cholinergic system, in particular the muscarinic M1 receptor, in schizophrenia and cognition and how allosteric compounds are being developed to address this undertreated aspect of the disease. We also discuss and compile mutagenesis studies of the muscarinic M1 receptor and how they relate to allosteric binding and function.