Messenger RNA vaccines for tuberculosis prevention: A narrative review of current research and prospects

doi:10.5497/wjp.v14.i1.110200

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (302)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series.

Item

Count

PDF

HTML

Figures (1-2)

Sum=59

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

106

Sum=169

Publishing Process of This Article

Item

Count

Browse

Download

Sum=69

Nov 19, 2025 (publication date) through Nov 23, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Pharmacology

ISSN

2220-3192

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Pharmacol. Nov 19, 2025; 14(1): 110200
Published online Nov 19, 2025. doi: 10.5497/wjp.v14.i1.110200

Messenger RNA vaccines for tuberculosis prevention: A narrative review of current research and prospects

Tanzeela Sameen Saeed, Muhammad Ramish Saeed, Muhammad Fahad Abdullah, Muhammad Shoaib Qureshi, Armeen Saeed, Sajal Munawar, Muneeb Saifullah, Ikra Rana

Tanzeela Sameen Saeed, Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan

Muhammad Ramish Saeed, Muneeb Saifullah, Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan

Muhammad Fahad Abdullah, Armeen Saeed, Sajal Munawar, Department of Medicine, Allama Iqbal Medical College, Lahore 54000, Punjab, Pakistan

Muhammad Shoaib Qureshi, Department of Medicine, King Edward Medical University, King Edward Medical University, Lahore 54000, Punjab, Pakistan

Ikra Rana, Department of Medicine, International School of Medicine, International University of Kyrgyzstan, Bishkek 720074, Kyrgyzstan

Author contributions: Saeed TS and Saeed MR conceived the manuscript and provided critical revisions; Abdullah MF, Qureshi MS, Saeed A, and Munawar S contributed to the drafting and editing of the manuscript; Saifullah M and Rana I were involved in literature review, manuscript preparation, and final revisions; all authors reviewed and approved the final version of the manuscript.

Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ikra Rana, MD, Department of Medicine, International School of Medicine, International University of Kyrgyzstan, 6 Street, Bishkek 720074, Kyrgyzstan. ikrarana100@gmail.com

Received: June 3, 2025
Revised: August 7, 2025
Accepted: October 15, 2025
Published online: November 19, 2025
Processing time: 167 Days and 15.8 Hours

Core Tip

Core Tip: This narrative review explores the emerging role of messenger RNA (mRNA) vaccines in the prevention of tuberculosis (TB). It highlights their immunological advantages, summarizes promising preclinical and early clinical findings, and critically discusses the limitations of current models, including TB pathogenesis, immune evasion, and vaccine delivery challenges. The narrative review provides a forward-looking perspective on how mRNA platforms could overcome the shortcomings of the Bacillus Calmette-Guérin vaccine and reshape global TB prevention strategies.