Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs

doi:10.5497/wjp.v12.i4.35

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 4

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7336)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-8) series, Tables (1-7) series.

Item

Count

PDF

194

WORD

HTML

3078

Figures (1-8)

568

Tables (1-7)

561

Sum=4426

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

370

Download

1200

Sum=1570

Publishing Process of This Article

Item

Count

Browse

239

Download

859

Sum=1098

Dec 22, 2023 (publication date) through Feb 27, 2026

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Pharmacology

ISSN

2220-3192

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Pharmacol. Dec 22, 2023; 12(4): 35-52
Published online Dec 22, 2023. doi: 10.5497/wjp.v12.i4.35

Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs

Lumír Hanuš, Tuvia Naor, Tatyana Gloriozova, Valery M Dembitsky

Lumír Hanuš, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel

Tuvia Naor, Food Chemistry, Kibbutz, Yotvata 8882000, Israel

Tatyana Gloriozova, Department of Bioinformatics, Institute of Biomedical Chemistry, Moscow 119121, Russia

Valery M Dembitsky, Centre for Applied Research and Innovation, Lethbridge College, Lethbridge AB T1K 1L6, Canada

Co-corresponding authors: Lumír Hanuš and Valery M Dembitsky.

Author contributions: Hanuš L carried out the extraction and analysis of volatile components of yellow and green fruits, seeds, and jam from the scrambling shrub Capparis cartilaginea; Naor T grew the material and provided it for analysis; Gloriozova T determined the biological activity of volatile components; Dembitsky VM prepared the article for publication and also wrote and reviewed this article; and all authors read and approved the final version of the manuscript. In addition, the co-corresponding authors contributed equally to the accompanying manuscript, such as describing the methods, their application to the analysis, and writing the discussion.

Institutional review board statement: The study was conducted in silico and did not include humans or animals, so a statement from the Institutional Review Board was not necessary.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The study was conducted only in a computational environment and the data and three-dimensional structures used are available in public online databases.

Corresponding author: Lumír Hanuš, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel. lumirh@ekmd.huji.ac.il

Received: August 28, 2023
Peer-review started: August 28, 2023
First decision: September 19, 2023
Revised: October 12, 2023
Accepted: November 24, 2023
Article in press: November 24, 2023
Published online: December 22, 2023
Processing time: 110 Days and 16.7 Hours

Abstract

BACKGROUND

Using gas chromatography-mass spectrometry (GC/MS) analysis, we examined the composition of volatile components present in the yellow and green fruits, seeds, and jam of the scrambling shrub Capparis cartilaginea (C. cartilaginea). These plant samples were collected from Kibbutz Yotvata in Israel. In all the tested samples, isothiocyanates were identified. Utilizing the PASS program, we ascertained the biological activity of these isothiocyanates present in the Capparis genus. The study results highlighted that all isothiocyanates could potentially act as apoptosis agonists, making them strong candidates for antitumor drugs. This information holds significant value for the fields of medicinal chemistry, pharmacology, and practical medicine.

AIM

To investigate the volatile components present in the yellow and green fruits, seeds, and jam of the C. cartilaginea shrub using GC/MS analysis, to detect isothiocyanates in all the analyzed plant samples, and to assess the biological activity of these isothiocyanates utilizing the PASS program.

METHODS

We utilized two primary methods to analyze the volatile compounds present in the yellow and green fruits, seeds, and jams of the C. cartilaginea, native to Israel. We identified biologically active isothiocyanates in these samples. Their anticipated biological activities were determined using the PASS program, with the most dominant activities being apoptosis agonist, anticarcinogenic, and antineoplastic specifically for genitourinary cancer.

RESULTS

Fruits, seeds, and jams containing isothiocyanates, which exhibit antineoplastic and anticarcinogenic activities, could be suggested for cancer prevention and management. Specific isothiocyanates, with therapeutic potential in this realm, could be recommended as potent anticancer agents in practical medicine following clinical trials.

CONCLUSION

The discovery that isothiocyanates exhibit potent antineoplastic and anticarcinogenic activities was unexpected. Additionally, certain isothiocyanates demonstrated antifungal, antiviral (specifically against arbovirus), and antiparasitic properties.

Keywords: Capparis cartilaginea; Fruits; Seeds; Isothiocyanates; Apoptosis; Anticancer

Core Tip: Using gas chromatography-mass spectrometry analysis, we examined the composition of volatile components present in the yellow and green fruits, seeds, and jam of the scrambling shrub Capparis cartilaginea. Fruits, seeds, and jams containing isothiocyanates, which exhibit antineoplastic and anticarcinogenic activities, could be suggested for cancer prevention and management. Specific isothiocyanates, with therapeutic potential in this realm, could be recommended as potent anticancer agents in practical medicine following clinical trials.