Platelet indices in neonatal sepsis: A review

Core Tip

Core tip: Sepsis in neonates often results in thrombocytopenia and changes in platelet indices. The important platelet indices such as mean platelet volume (MPV), platelet distribution width and plateletcrit are related to morphology and proliferation kinetics of platelets. All these indices are readily available with no additional cost while performing routine blood counts using autoanalyzers. Studies in adult patients reported the potential role of platelet indices in the diagnosis of severe sepsis and prognosis of adverse clinical outcomes including mortality. Abnormal MPV can aid diagnosing the cause of thrombocytopenia. Low MPV associated with thrombocytopenia has been found to result in clinical bleeding. The current review gives an overview of potential utility of important platelet indices in neonatal sepsis.