Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus

doi:10.5495/wjcid.v12.i1.20

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Basic Study

World J Clin Infect Dis. Apr 26, 2022; 12(1): 20-32
Published online Apr 26, 2022. doi: 10.5495/wjcid.v12.i1.20

Mutations of the brpR and brpS genes affect biofilm formation in Staphylococcus aureus

Allison Zank, Lillian Schulte, Xavier Brandon, Lauren Carstensen, Amy Wescott, William R Schwan

Allison Zank, Lillian Schulte, Xavier Brandon, Lauren Carstensen, Amy Wescott, William R Schwan, Department of Microbiology, University of Wisconsin-La Crosse, La Crosse, WI 54601, United States

Author contributions: Zank A, Wescott A, and Schwan WR designed the research study; Zank A, Schulte L, Brandon X, Carstensen L, Wescott A, and Schwan WR performed the research; Zank A, Brandon X, and Schwan WR contributed new plasmids; Zank A, and Schwan WR analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.

Supported by National Science Foundation Graduate Research Program to Zank A, No. 0002016179620.

Institutional review board statement: No humans or samples from human were used in this study.

Institutional animal care and use committee statement: No animals were used in this study.

Conflict-of-interest statement: Schwan WR holds a composition of matter and use patent covering the SK-03-92 Lead compound.

Data sharing statement: The authors will share their data with whomever asks.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: William R Schwan, PhD, Professor, Department of Microbiology, University of Wisconsin-La Crosse, 1725 State St, La Crosse, WI 54601, United States.wschwan@uwlax.edu

Received: September 2, 2021
Peer-review started: September 2, 2021
First decision: November 22, 2021
Revised: December 3, 2021
Accepted: February 12, 2022
Article in press: February 12, 2022
Published online: April 26, 2022
Processing time: 234 Days and 19.6 Hours

Core Tip

Core Tip: Staphylococcus aureus is a primary cause of skin/soft tissue infections. In this study, we have shown that two previously uncharacterized genes, brpR and brpS, encode proteins that we believe comprise a two-component system that regulates biofilm formation in S. aureus.