• Helicobacter pylori
• Cohort
• Ethnicity
• Europe
• Hypertension
• Preeclampsia
• Pregnancy outcomes

• Humans
• Pregnancy
• Female
• Helicobacter pylori/immunology
• Helicobacter Infections/epidemiology
• Helicobacter Infections/complications
• Adult
• Pregnancy Complications, Infectious/epidemiology
• Pregnancy Complications, Infectious/microbiology
• Pregnancy Complications, Infectious/immunology
• Pregnancy Outcome/epidemiology
• Premature Birth/epidemiology
• Premature Birth/microbiology
• United Kingdom/epidemiology
• Spain/epidemiology
• Diabetes, Gestational/epidemiology
• Diabetes, Gestational/microbiology
• Diabetes, Gestational/immunology
• Greece/epidemiology
• Pre-Eclampsia/epidemiology
• Pre-Eclampsia/microbiology
• Hypertension, Pregnancy-Induced/epidemiology
• Birth Cohort
• Infant, Small for Gestational Age
• Risk Factors
• Cohort Studies
• Immunoglobulin G/blood
• Antibodies, Bacterial/blood
• Young Adult
• Infant, Newborn

• Helicobacter pylori
• Mendelian randomization
• preeclampsia
• pregnancy
• premature rupture of membranes

• Female
• Humans
• Infant, Newborn
• Pregnancy
• Antibodies, Bacterial
• Eclampsia
• Genome-Wide Association Study
• Helicobacter Infections/complications
• Helicobacter pylori/genetics
• Immunoglobulin G
• Longitudinal Studies
• Mendelian Randomization Analysis
• Placenta
• Pre-Eclampsia/epidemiology
• Pre-Eclampsia/genetics
• Premature Birth/epidemiology
• Meta-Analysis as Topic

• G9815508 Medical Research Council
• MC_PC_15018 Medical Research Council
• MC_PC_19009 Medical Research Council

Helicobacter pylori (H. Pylori) is a gram-negative, flagellated and spiral-shaped bacterial pathogen that impacts approximately 46% among pregnant women globally and has been associated with various maternal-fetal complications. Iron deficiency anemia, fetal growth restriction, cardiovascular diseases, and insufficient nutrient absorption can be observed in pregnant women, as well as miscarriages and pregnancy-specific hypertensive disease, such as pre-eclampsia. Thus, the evidence supports the influence of H. pylori infection on fetal implantation/placentation failure, and positive strains of the cytotoxin-associated gene A of H. Pylori were reported as the most prevalent in these conditions. However, current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum, characterized by frequent nausea and vomiting. Regarding the diagnosis of this bacterial infection, non-invasive approaches such as stool antigen test, urea breath test, and serological tests are more accepted during pregnancy, as they are easy to carry out and cost-effective. Finally, the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child, with pharmacological intervention depending on the clinical presentation.

• Helicobacter pylori
• Pregnancy
• Hyperemesis gravidarum
• Iron deficiency anemia
• Pre-eclampsia
• Fetal growth restriction
• Miscarriage

Helicobacter pylori infections are associated with many complications of pregnancy including preeclampsia. It has been suggested that H. pylori infection could contribute to the etiopathogenesis of preeclampsia by inducing a pro-inflammatory state.

To assess the magnitude of H. pylori infection and its association with preeclamptic and non-preeclamptic pregnant women attending antenatal care in Ethiopia.

Hospital-based case control study was conducted among clinically diagnosed preeclamptic and non-preeclamptic pregnant women. Stool samples were collected for H. pylori antigen test from study participants. The collected data were analyzed using statistical methods in SPSS version 23. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the study subjects. Association between clinical variables, preeclampsia and H. pylori infection was performed with multivariate logistic regression. A p-value of <0.05 at 95% confidence level was considered as statistically significant in all the analyses.

A total of 93 cases and 186 controls were included in this study. The overall prevalence of H. pylori infection in all study participants was 38.9% (16/272). The prevalence of H. pylori infection was higher in cases than controls, 54.3% (50/92) vs 31.1% (56/180), respectively. The mean age was 29.01 (SD±4.93) years in cases and 30.37 (SD± 6.2) years in control group. A positive association was found between H. pylori infection and preeclampsia (OR: 2.45; 95% CI: 2.41–4.10).

H. pylori infection has been found to be associated with preeclamptic pregnant women. In this study, the prevalence of H. pylori infection was higher in cases than in controls. Age group, educational status, occupational status and body mass index were significantly associated with preeclamptic women with H. pylori. The association of H. pylori with preeclampsia needs to be further explored.

• Helicobacter pylori
• preeclampsia
• pregnant women

• Helicobacter pylori
• bioinformatic tools
• built-in adjuvants
• epitope-based vaccines
• epitopes

• newborns
• peptic ulcer disease
• pregnancy

• Child
• Gestational hypertension
• Ghrelin
• Growth and development
• H. pylori
• Insulin-like growth factor-1
• Pregnancy

Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks’ gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Despite its prevalence, the risk factors that have been identified lack accuracy in predicting its onset and preventative therapies only moderately reduce a woman’s risk of preeclampsia. Preeclampsia is a major cause of maternal morbidity and is associated with adverse foetal outcomes including intra-uterine growth restriction, preterm birth, placental abruption, foetal distress, and foetal death in utero. At present, national guidelines for foetal surveillance in preeclamptic pregnancies are inconsistent, due to a lack of evidence detailing the most appropriate assessment modalities as well as the timing and frequency at which assessments should be conducted. Current management of the foetus in preeclampsia involves timely delivery and prevention of adverse effects of prematurity with antenatal corticosteroids and/or magnesium sulphate depending on gestation. Alongside the risks to the foetus during pregnancy, there is also growing evidence that preeclampsia has long-term adverse effects on the offspring. In particular, preeclampsia has been associated with cardiovascular sequelae in the offspring including hypertension and altered vascular function.

• developmental origins of disease
• foetal diseases
• foetus
• non-communicable disease
• preeclampsia
• pregnancy
• prevention
• treatment

• Helicobacter pylori
• extragastric diseases
• molecular mimicry

• Calcium
• Dietary Supplements
• Double-Blind Method
• Female
• Humans
• Pre-Eclampsia
• Pregnancy
• Pregnancy Complications, Cardiovascular

• Alzheimer
• Association
• Meta-analysis
• Parkinson
• Toxoplasma gondii infection

• Alzheimer Disease/etiology
• Antibodies, Protozoan/blood
• Humans
• Parkinson Disease/etiology
• Risk Factors
• Toxoplasmosis/complications

• Eclampsia
• Human Immunodeficiency Virus
• Meta-analysis
• Pre-eclampsia

• Children
• Diagnosis
• Helicobacter pylori

A novel fecal test was developed to detect H. pylori based on immunomagnetic beads (IMBs) with monoclonal antibodies sensitively recognizing and capturing the H. pylori, coupled with a polyclonal antibody-conjugating quantum dot probe.

• diabetes mellitus
• hepatic encephalopathy
• idiopathic thrombocytopenic purpura
• iron deficiency anemia
• metabolic syndrome
• molecular mimicry
• nonalcoholic fatty liver disease

• hypertension
• preeclampsia
• pregnancy
• risk factors
• sepsis
• stroke

• Adult
• Black or African American/statistics & numerical data
• Asian/statistics & numerical data
• Blood Coagulation Disorders/epidemiology
• California/epidemiology
• Case-Control Studies
• Cesarean Section/statistics & numerical data
• Delivery, Obstetric
• Ethnicity/statistics & numerical data
• Female
• Florida/epidemiology
• Hispanic or Latino/statistics & numerical data
• Hospital Mortality
• Hospitalization
• Humans
• Hypertension/epidemiology
• Hypertension, Pregnancy-Induced/epidemiology
• Logistic Models
• Multivariate Analysis
• New York/epidemiology
• Odds Ratio
• Peripartum Period
• Pregnancy
• Pregnancy Complications, Cardiovascular/epidemiology
• Pregnancy Complications, Infectious/epidemiology
• Puerperal Disorders/epidemiology
• Puerperal Infection/epidemiology
• Pulmonary Embolism/epidemiology
• Reproductive Tract Infections/epidemiology
• Risk Factors
• Sepsis/epidemiology
• Stroke/epidemiology
• Thrombophilia/epidemiology
• Urinary Tract Infections/epidemiology
• Venous Thrombosis/epidemiology
• White People/statistics & numerical data

• R03 NS101417 NINDS NIH HHS
• R21 MD012451 NIMHD NIH HHS
• U24 NS107237 NINDS NIH HHS
• U10 NS086728 NINDS NIH HHS
• K08 HD082287 NICHD NIH HHS

• Female
• Helicobacter Infections/epidemiology
• Helicobacter pylori
• Humans
• Pre-Eclampsia/epidemiology
• Pregnancy
• Risk Factors