Melanocortin 4 receptor mutation in obesity

Table 1 Melanocortin receptors

Name	Tissue expression	Principal actions
MC1R	Skin, hair follicles	Regulates pigmentation
MC2R	Adrenal cortex	Regulates adrenal steroidogenesis
MC3R	Central nervous system	Regulates energy homeostasis
MC4R	Central nervous system	Regulates energy homeostasis
MC5R	Exocrine glands; wide expression	Regulates exocrine gland secretion

MCR: Melanocortin receptors.

Table 2 Drugs for use in genetic forms of obesity

Drug	Analogue
Setmelanotide	Analogue of α-melanocyte melanocyte-stimulating hormone
Metreleptin	Human leptin analogue
Liraglutide	Glucagon-like peptide-1 analogue
Semaglutide	Long-acting glucagon-like peptide-1 analogue
Others