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World J Exp Med. Dec 20, 2024; 14(4): 99239
Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.99239
Melanocortin 4 receptor mutation in obesity
Gumpeny R Sridhar, Lakshmi Gumpeny
Gumpeny R Sridhar, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, Visakhapatnam 530002, Andhra Pradesh, India
Lakshmi Gumpeny, Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, Andhra Pradesh, India
Author contributions: Both authors contributed to this manuscript. Sridhar GR designed the concept and outline; Lakshmi G contributed to the writing and editing of the manuscript.
Conflict-of-interest statement: Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gumpeny R Sridhar, FRCP (Hon), Adjunct Professor, Department of Endocrinology and Diabetes, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, Andhra Pradesh, India. sridharvizag@gmail.com
Received: July 18, 2024
Revised: August 22, 2024
Accepted: August 27, 2024
Published online: December 20, 2024
Processing time: 104 Days and 16.9 Hours
Core Tip

Core Tip: The leptin-melanocortin pathway regulates energy balance and body weight. Melanocortin-4 receptor (MC4R) plays a key role in this pathway by reducing hunger, inducing satiety and increasing energy expenditure. Mutations of MC4R result in obesity and hyperphagia in childhood. Setmelanotide is an MC4R agonist approved for use in obesity caused by leptin-melanocortin pathway dysfunction.