Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis

Table 1 Baseline patient clinical, pathological and treatment information

Clinical and pathological data	Patients
	n	%
Age (yr)
< 60	23	33.3
60-69	36	52.2
≥ 70	10	14.5
Gender
Male	67	97.1
Female	2	2.9
Tumor location
Upper lobe	45	65.2
Middle lobe	1	1.5
Lower lobe	21	30.4
Main bronchus	2	2.9
Lateral origin
Left	31	44.9
Right	38	55.1
Tumor localization
Central	57	82.6
Peripheral	12	17.4
Histology
KSCC	18	26.1
NKSCC	51	74.9
Grade
G1	11	15.9
G2	41	59.4
G3	17	24.7
T stage
T1b	7	10.1
T2a	30	43.5
T2b	6	8.7
T3a	26	37.7
N stage
N0	10	14.5
N1	38	55.1
N2	31	30.4
Stage
IIb	37	53.6
IIIa	32	46.4
Type of surgery
Lobectomy	29	42.0
Pneumonectomy	40	58.0

KSCC: Keratinizing squamous cell carcinoma; NKSCC: Nonkeratinizing squamous cell carcinoma.

Table 2 Characteristics of patients with and without recurrence of lung squamous cell carcinoma

	Patients with recurrence of LSCC		Patients without recurrence of LSCC		P value
	n	%	n	%
Age (yr)
< 60	15	30.6	8	40.0	0.72
60-69	27	55.1	9	45.0
≥ 70	7	14.3	3	15.0
Gender
Male	47	95.9	20	100.0	0.359
Female	2	4.1	0	0.0
Tumor location
Upper lobe	35	71.5	10	50.0	0.193
Middle lobe	0	0.0	1	5.0
Lower lobe	13	26.5	8	40.0
Main bronchus	1	2.0	1	5.0
Lateral origin
Left	25	51.1	6	30.0	0.111
Right	24	48.9	14	70.0
Tumor localization
Central	43	87.8	14	70.0	0.08
Peripheral	6	12.2	6	30.0
Histology
KSCC	10	20.4	8	40.0	0.193
NKSCC	39	79.6	12	60.0
Grade
G1	8	16.3	3	15.0	0.040
G2	25	51.0	16	80.0
G3	16	32.7	1	5.0
T stage
T1b	5	10.2	2	10.0	0.559
T2a	24	48.9	6	30.0
T2b	4	8.2	2	10.0
T3a	16	32.7	10	50.0
N stage
N0	4	8.2	6	30.0	0.05
N1	30	61.2	8	40.0
N2	15	30.6	6	30.0
Stage
IIb	25	51.0	12	60.0	0.497
IIIa	24	49.0	8	40.0
Type of surgery
Lobectomy	19	38.8	10	50.0	0.618
Pneumonectomy	30	61.2	10	50.0

KSCC: Keratinizing squamous cell carcinoma; NKSCC: Nonkeratinizing squamous cell carcinoma.

Table 3 Univariate and multifactorial logistic regression analysis

Characteristic	Univariate analysis OR (95%CI)	P value	Multivariate analysis OR (95%CI)	P value
Age (yr)
< 60	1	-
60-69	1.60 (0.51-5.02)	0.420
≥ 70	1.24 (0.25-6.17)	0.789
Tumor localization
Peripheral	1	-
Central	3.07 (0.85-11.07)	0.089
Histology
KSCC	1	-
NKSCC	2.60 (0.84-8.07)	0.101
Grade
G1	1	-	1	-
G2	0.59 (0.13-2.54)	0.590	0.91 (0.44-4.56)	0.345
G3	6.00 (1.01-67.28)	0.0211	7.94 (1.08-135.81)	0.0481
T stage
T1b	1	-
T2a	1.62 (0.25-10.36)	0.622
T2b	0.80 (0.08-8.47)	0.853
T3	0.63 (0.10-3.95)	0.631
N stage
N0	1	-	1	-
N1	5.63 (1.27-24.86)	0.0231	5.67 (1.09-36.54)	0.0481
N2	3.75 (0.77-18.21)	0.101	6.30 (0.78-50.78)	0.08
Stage
IIb	1	-
IIIa	1.44 (0.50-4.14)	0.498
DCs of “contact type”
Presence	1	-
Absence	1.61 (0.53-4.91)	0.404
The capillaries in the tumor solid component
Absence	1	-
Presence	2.24 (0.74-6.79)	0.154
LFFCT in the tumor stroma
Absence	1	-	1	-
Presence	15.33 (3.56-66.04)	0.00021	21.70 (4.27-110.38)	0.00021
Fragmentation in the tumor solid component
Absence	1	-	1	-
Presence	3.42 (1.06-11.03)	0.0401	2.53 (1.01-12.23)	0.0491
Peritumoral retraction clefting
Absence	1	-
Presence	0.41 (0.13-1.30)	0.13
Tumor spread in the AAS
Absence	1	-
Presence	1.08 (0.38-3.07)	0.883

¹The differences between groups are statistically significant, P < 0.05.

AAS: Alveolar air spaces; DCs: Dilated capillaries; KSCC: Keratinizing squamous cell carcinoma; LFFCT: Loose, fine-fiber connective tissue in the tumor stroma; NKSCC: Nonkeratinizing squamous cell carcinoma.