Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 20, 2024; 14(1): 89319
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.89319
Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis
Marina A Senchukova, Evgeniy A Kalinin, Nadezhda N Volchenko
Marina A Senchukova, Department of Oncology, Orenburg State Medical University, Orenburg 460000, Russia
Evgeniy A Kalinin, Department of Thoracic Surgery, Orenburg Regional Cancer Clinic, Orenburg 460021, Russia
Nadezhda N Volchenko, Department of Pathology, P. A. Hertzen Moscow Oncology Research Centre, National Medical Research Centre of Radiology, Moscow 125284, Russia
Author contributions: Senchukova MA designed and performed the research, and wrote the paper; Kalinin EA acquired and analyzed the data and contributed substantially to the conception and design of the study; Volchenko NN participated in the discussion of related data, and revised and approved the final version; all the authors wrote and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by Ethics Committee of Orenburg State Medical University (Russia, Orenburg).
Informed consent statement: Patients were not required to give informed consent to the study because the study was retrospective and analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
Data sharing statement: Data from patients included in the study in Statistica10 table or Excel table format can be provided upon request to the corresponding author at masenchukova@yandex.com.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marina A Senchukova, MD, PhD, Professor, Department of Oncology, Orenburg State Medical University, Sovetskaya Street, 6, Orenburg 460000, Russia. masenchukova@yandex.com
Received: October 27, 2023
Peer-review started: October 27, 2023
First decision: December 7, 2023
Revised: December 20, 2023
Accepted: January 10, 2024
Article in press: January 10, 2024
Published online: March 20, 2024
Processing time: 143 Days and 23.6 Hours
Core Tip

Core Tip: This study identified the following independent predictors of a high risk of disease recurrence in patients with stage IIb-IIIa lung squamous cell carcinoma treated by radical resection and adjuvant chemotherapy: a low degree of tumor differentiation, metastases in regional lymph nodes, the presence of loose, fine-fiber connective tissue in the tumor stroma and fragmentation of the tumor solid component. The area under the curve of the predictive model was 0.846. The sensitivity, accuracy and specificity of the methods were 91.8%, 86.9% and 75.0%, respectively. The developed method allows us to identify a group of patients at high risk of disease relapse and to adjust the treatment.