Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury

doi:10.5493/wjem.118828

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 2

This Article

(3)

(4)

(0)

(2)

(1)

(41)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Experimental Medicine

ISSN

2220-315x

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Jun 20, 2026; 16(2): 118828
Published online Jun 20, 2026. doi: 10.5493/wjem.118828

Open in New Tab Full Size Figure Download Figure

Figure 1 Histopathological findings in liver tissue. A: Normal liver tissue, control group, hematoxylin and eosin staining (HE) × 100; B: Ischemia-reperfusion group, HE × 100; C: Ischemia-reperfusion rectal ozone group, HE × 100; D: Ischemia-reperfusion intrathecal ozone group, HE × 100; E: Ischemia-reperfusion intraperitoneal ozone group, HE × 100, scale bar 50 μm. Green arrow: Vena centralis; orange arrow: Degeneration; black arrow: Inflammation; yellow arrow: Hepatocytes.

Open in New Tab Full Size Figure Download Figure

Figure 2 Histopathological findings in lung tissue. A: Normal lung tissue, control group, hematoxylin and eosin staining (HE) × 100; B: Ischemia-reperfusion group, HE × 100; C: Ischemia-reperfusion rectal ozone group, HE × 100; D: Ischemia-reperfusion intrathecal ozone group, HE × 100; E: Ischemia-reperfusion intraperitoneal ozone group, HE × 100, scale bar 50 μm. Green arrow: Terminal bronchiole; orange arrow: Congestion/fibrosis; black arrow: Inflammation; yellow arrow: Alveoli.

Open in New Tab Full Size Figure Download Figure

Figure 3 Histopathological findings in brain tissue. A: Normal brain tissue, control group, hematoxylin and eosin staining (HE) × 100; B: Ischemia-reperfusion group, HE × 100; C: Ischemia-reperfusion rectal ozone group, HE × 100; D: Ischemia-reperfusion intrathecal ozone group, HE × 100; E: Ischemia-reperfusion intraperitoneal ozone group, HE × 100, scale bar 50 μm. Yellow arrow: Granular cells; orange arrow: Degeneration; black arrow: Inflamation; green arrow: Pyramidal cells.

Open in New Tab Full Size Figure Download Figure

Figure 4 Rat oxidant status parameters. A: Rat liver tissue; B: Rat lung tissue; C: Rat brain tissue. ^aP < 0.05: Compared to the control group. ^bP < 0.05: Compared to the ischemia-reperfusion group. ^cP < 0.05: Compared to the ischemia-reperfusion rectal ozone group. C group: Control group; IR group: Ischemia-reperfusion group; IRRO group: Ischemia-reperfusion rectal ozone group; IRITO group: Ischemia-reperfusion intrathecal ozone group; IRIPO group: Ischemia-reperfusion intraperitoneal ozone group; MDA: Malondialdehyde; CAT: Catalase.

Citation: Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; 16(2): 118828
URL: https://www.wjgnet.com/2220-315x/full/v16/i2/118828.htm
DOI: https://dx.doi.org/10.5493/wjem.118828

Şengel N, Köksal Z, Küçük A, Sezen ŞC, Güneş I, Atlı M, Kip G, Gökgöz Acar S, Özer A, Kavutçu M, Arslan M. Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury. World J Exp Med 2026; 16(2): 118828 [DOI: 10.5493/wjem.118828]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.