Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma

Figure 1 Immunoexpression of E cadherin and zinc-finger E-box-binding homeobox 1 in oral epithelial dysplasia. A: Immuno-expression of E-cadherin is intense and membranous in mild dysplasia [immunohistochemistry (IHC), 10 ×]; B: Immuno-expression of E-cadherin is intense and membranous with focal areas of cytoplasmic relocation in moderate dysplasia (IHC, 10 ×); C: Immuno-expression of E-cadherin is mild and membranous with focal areas of cytoplasmic relocation in severe dysplasia (IHC, 10 ×); D: Immuno-expression of zinc-finger E-box-binding homeobox 1 (ZEB1) is intense and nuclear in mild dysplasia (IHC, 10 ×); E: Immuno-expression of ZEB1 is intense and nuclear as well as cytoplasmic in moderate dysplasia (IHC, 10 ×); F: Immuno-expression of ZEB1 is intense and nuclear as well as cytoplasmic in severe dysplasia (IHC, 10 ×).

Figure 2 Immuno-expression of E cadherin in oral squamous cell carcinoma. A: Immuno-expression of E-cadherin is reduced with cytoplasmic relocation in oral squamous cell carcinoma (OSCC) [immunohistochemistry (IHC), 4 ×]; B: Immuno-expression of E-cadherin is reduced with cytoplasmic relocation in OSCC (IHC, 10 ×); C: Immuno-expression of E-cadherin is reduced with cytoplasmic relocation in OSCC (IHC 40 ×).

Figure 3 Immunoexpression of zinc-finger E-box-binding homeobox 1 in oral squamous cell carcinoma. A: Immuno-expression of zinc-finger E-box-binding homeobox 1 (ZEB1) is intense and shows cytoplasmic expression in oral squamous cell carcinoma (OSCC) [immunohistochemistry (IHC) 4 ×]; B: Immuno-expression of ZEB1 is intense and shows cytoplasmic expression in OSCC (IHC 10 ×); C: Immuno-expression of ZEB1 is intense and shows cytoplasmic expression in OSCC (IHC 40 ×).