Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Exp Med. Jun 20, 2026; 16(2): 118228
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.118228
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.118228
Letter to the Editor: Circadian and microbial misalignment in metabolic dysfunction-associated steatotic liver disease - mechanistic insights and chronotherapeutic potential
Christos Savvidis, Ioannis Ilias, Department of Endocrinology, Hippocration General Hospital, Athens 11527, Greece
Author contributions: Savvidis C and Ilias I read the literature and drafted this work; Savvidis C and Ilias I revised this work according to reviews; Savvidis C and Ilias I agree to its submission.
Conflict-of-interest statement: Both authors declare that they have no conflict of interest to report.
Corresponding author: Ioannis Ilias, MD, PhD, Director, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens 11527, Greece.
Received: December 31, 2025
Revised: January 22, 2026
Accepted: February 4, 2026
Published online: June 20, 2026
Processing time: 168 Days and 12 Hours
Revised: January 22, 2026
Accepted: February 4, 2026
Published online: June 20, 2026
Processing time: 168 Days and 12 Hours
Core Tip
Core Tip: The gut-liver axis is a rhythmic system regulated by a bidirectional interaction between host clocks and the gut microbiota. Social jetlag disrupts the timing of metabolites and compromises the intestinal barrier, exacerbating metabolic injury in metabolic dysfunction-associated steatotic liver disease. Restoration of these rhythms through chronotherapeutic approaches provides an effective method to restore alignment and improve clinical outcomes.