Beyond distance and heart rate: Reading 6-minute walk test via blood pressure variability in chronic heart failure

doi:10.5493/wjem.v16.i2.116315

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Jun 20, 2026; 16(2): 116315
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.116315

Beyond distance and heart rate: Reading 6-minute walk test via blood pressure variability in chronic heart failure

Wen-Lu Xing, Tong Liu

Wen-Lu Xing, Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China

Wen-Lu Xing, Department of Cardiology, Big Data Center for Cardiovascular Disease, Central China Fuwai Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou 450018, Henan Province, China

Author contributions: Xing WL and Liu T drafted and revised the manuscript; and all authors reviewed and approved the final version.

Supported by the Tianjin Key Medical Discipline Construction Project, No. TJYXZDXK-3-006B.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Tong Liu, Professor, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin 300211, China. liutongdoc@126.com

Received: November 10, 2025
Revised: December 15, 2025
Accepted: February 2, 2026
Published online: June 20, 2026
Processing time: 215 Days and 21 Hours

Core Tip

Core Tip: The six-minute walk test (6MWT) is a tool for the assessment of exercise capacity in chronic heart failure. During beta-blocker therapy, heart-rate readouts during 6MWT are often blunted. Blood pressure variability measured in the recovery window following 6MWT may overcome this limitation, offering a low-cost method to assess compensatory reserve and enhance cardiac interpretation.