Retrospective Cohort Study
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World J Exp Med. Mar 20, 2025; 15(1): 99516
Published online Mar 20, 2025. doi: 10.5493/wjem.v15.i1.99516
Prevalence of RUNX1 gene alterations in de novo adult acute myeloid leukemia
Hoda M Abd El-Ghany, Mona S El Ashry, Mona S Abdellateif, Ahmed Rabea, Nada Sultan, Omnia Y Abd El Dayem
Hoda M Abd El-Ghany, Omnia Y Abd El Dayem, Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo 11976, Al Qāhirah, Egypt
Mona S El Ashry, Nada Sultan, Department of Clinical Pathology, National Cancer Institute, Cairo University, Cairo 11976, Al Qāhirah, Egypt
Mona S Abdellateif, Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11976, Al Qāhirah, Egypt
Ahmed Rabea, Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo 11976, Al Qāhirah, Egypt
Author contributions: Abd El-Ghany HM and Abd El Dayem OY supervised the work and revised the paper; Rabea A managed and performed a follow-up of the patients; Abdellateif MS shared in the molecular work and analyzed the data; Sultan N performed the cytogenetics work and collected the data; El Ashry MS supervised the cytogenetic work and wrote the manuscript.
Institutional review board statement: The study was conducted following the Helsinki Declaration of 2011 and was approved by the internal review board of the National Cancer Institute and the Faculty of Medicine Research Ethics Committee at Cairo University (Code: MS-38-2020).
Informed consent statement: Every patient gave written informed consent.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mona S Abdellateif, MD, PhD, Professor, Department of Cancer Biology, National Cancer Institute, Cairo University, 1 Fom Elkhaligue, Cairo 11976, Al Qāhirah, Egypt. mona.sayed@nci.cu.edu.eg
Received: July 24, 2024
Revised: September 17, 2024
Accepted: October 22, 2024
Published online: March 20, 2025
Processing time: 154 Days and 17.9 Hours
Core Tip

Core Tip: In the current study, we characterized the runt-related transcription factor-1 (RUNX1) gene rearrangements and copy number variations in patients with newly diagnosed adult acute myeloid leukemia with an emphasis on the impact of clinical and laboratory features on the outcome. RUNX1 abnormalities were mutually exclusive of NPM1 mutations. RUNX1 abnormalities affected neither patients’ response to treatment nor overall survival.