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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 20, 2025; 15(1): 97460
Published online Mar 20, 2025. doi: 10.5493/wjem.v15.i1.97460
Published online Mar 20, 2025. doi: 10.5493/wjem.v15.i1.97460
Diagnostic utility of microRNA profiles in cavitatory and non-cavitatory pulmonary tuberculosis: Research protocol
Swathy Moorthy, Emmanuel Bhaskar, Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nādu, India
Shivakumar Singh, Department of Medicine, Railway Hospital, Perumbur, Chennai, Chennai 600023, Tamil Nādu, India
Santhi Silambanan, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nādu, India
Author contributions: Moorthy S, Bhaskar E, Singh S, and Silambanan S designed the research study; Moorthy S, Bhaskar E, and Santhi S performed the research; Moorthy S and Santhi S contributed new reagents and analytic tools; Moorthy S, Bhaskar E, Singh S, and Silambanan S analyzed the data and wrote the manuscript. All authors have read and approved the final manuscript.
Institutional review board statement: The Institutional Ethics Committee has approved the study (IEC number IEC/21/JUN/163/43).
Clinical trial registration statement: The study is registered with Indian Council of Medical Research, India, CTRI/2023/08/056740 (https://ctri.nic.in/Clinicaltrials/Login.php).
Informed consent statement: Written informed consent will be obtained from all participants.
Conflict-of-interest statement: The authors declare that there were no conflicts of interest.
Data sharing statement: All the required data are provided in the article itself.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Santhi Silambanan, DNB, MD, Professor, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116, Tamil Nādu, India. santhisilambanan@sriramachandra.edu.in
Received: May 30, 2024
Revised: October 31, 2024
Accepted: December 9, 2024
Published online: March 20, 2025
Processing time: 209 Days and 11.2 Hours
Revised: October 31, 2024
Accepted: December 9, 2024
Published online: March 20, 2025
Processing time: 209 Days and 11.2 Hours
Core Tip
Core Tip: Tuberculosis (TB) is a multisystem infectious disease. The route of entry of Mycobacterium tuberculosis is via the respiratory system, hence the commonest presentation is lung TB. It has various presentations from subtle lesions to cavitation in the lung. If not treated in time, it spreads to various organs which can increase morbidity and mortality. Current diagnostic tools lack sensitivity and are time-consuming. Identification of the microRNA profiles in TB could help in devising point-of-care testing which may be used at bed side or physician consulting rooms.