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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Oncometabolites in pancreatic cancer: Strategies and its implications
Arunima Maiti, Susmita Mondal, Sounetra Choudhury, Arnab Bandopadhyay, Sanghamitra Mukherjee, Nilabja Sikdar
Arunima Maiti, Suraksha Diagnostics Pvt Ltd, Newtown, Rajarhat, Kolkata 700156, West Bengal, India
Susmita Mondal, Department of Zoology, Diamond Harbour Women’s University, Diamond Harbour 743368, West Bengal, India
Sounetra Choudhury, Nilabja Sikdar, Human Genetics Unit, Indian Statistical Institute, Kolkata 700108, West Bengal, India
Arnab Bandopadhyay, Department of Oncology, Command Hospital, Lucknow 226002, India
Sanghamitra Mukherjee, Department of Pathology, RG Kar Medical College and Hospital, Kolkata 700004, West Bengal, India
Nilabja Sikdar, Scientist G, Estuarine and Coastal Studies Foundation, Howrah 711101, West Bengal, India
Author contributions: Maiti A, Mondal S, and Choudhury S prepared the draft, with figures, flow charts, and tables. Bandopadhyay A, Maiti A, Mukherjee S, and Sikdar N provided valuable inputs, suggestions, comments and guidance while writing the review manuscript and also contributed to proofreading and editing; Sikdar N constructed, conceptualized, and edited the review manuscript.
Supported by the Department of Biotechnology, Government of India, Ramalingaswami Re-entry Fellowship, No. RLS/BT/Re-entry/05/2012; and Department of Higher, Education, Science & Technology and Biotechnology, Government of West Bengal, India, No. BT/P/Budget/RD-37/2016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Nilabja Sikdar, PhD, Doctor, Researcher, Human Genetics Unit, Indian Statistical Institute, 203, BT Road, Kolkata 700108, West Bengal, India.
snilabja@gmail.com
Received: April 24, 2024
Revised: August 24, 2024
Accepted: September 14, 2024
Published online: December 20, 2024
Processing time: 189 Days and 22.7 Hours
Pancreatic cancer (PanCa) is a catastrophic disease, being third lethal in both the genders around the globe. The possible reasons are extreme disease invasiveness, highly fibrotic and desmoplastic stroma, dearth of confirmatory diagnostic approaches and resistance to chemotherapeutics. This inimitable tumor microenvironment (TME) or desmoplasia with excessive extracellular matrix accumulation, create an extremely hypovascular, hypoxic and nutrient-deficient zone inside the tumor. To survive, grow and proliferate in such tough TME, pancreatic tumor and stromal cells transform their metabolism. Transformed glucose, glutamine, fat, nucleotide metabolism and inter-metabolite communication between tumor and TME in synergism, impart therapy resistance, and immunosuppression in PanCa. Thus, a finer knowledge of altered metabolism would uncover its metabolic susceptibilities. These unique metabolic targets may help to device novel diagnostic/prognostic markers and therapeutic strategies for better management of PanCa. In this review, we sum up reshaped metabolic pathways in PanCa to formulate detection and remedial strategies of this devastating disease.
Core Tip: Pancreatic cancer (PanCa) is supported by reprogrammed metabolism. Cancer specific glucose, glutamine, fat, nucleotide metabolism and inter-metabolite communication between tumor and stroma, impart continual proliferation, therapy resistance, and immunosuppression. Key enzymes and intermediates of altered metabolic pathways would help to formulate disease specific markers and therapeutic approaches. This review sums up reformed metabolic pathways in PanCa to formulate detection and remedial strategies for better disease management.
