Can hydroxychloroquine be used for COVID-19-induced arthritis? A debatable hypothesis

doi:10.5493/wjem.v12.i6.108

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World Journal of Experimental Medicine

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Letter to the Editor

World J Exp Med. Dec 9, 2022; 12(6): 108-110
Published online Dec 9, 2022. doi: 10.5493/wjem.v12.i6.108

Can hydroxychloroquine be used for COVID-19-induced arthritis? A debatable hypothesis

Raktim Swarnakar, Sankha Subhra Roy, Shiv Lal Yadav

Raktim Swarnakar, Sankha Subhra Roy, Shiv Lal Yadav, Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India

Author contributions: Swarnakar R and Roy SS contributed to conception and design; Swarnakar R, Roy SS and Yadav SL contributed to literature search and writing.

Conflict-of-interest statement: All authors declare that they have no conflicts of interest.

Corresponding author: Raktim Swarnakar, MBBS, MD, Doctor, Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India. raktimswarnakar@hotmail.com

Received: October 10, 2022
Peer-review started: October 10, 2022
First decision: November 11, 2022
Revised: November 18, 2022
Accepted: December 7, 2022
Article in press: December 7, 2022
Published online: December 9, 2022
Processing time: 59 Days and 9.8 Hours

Abstract

Hydroxychloroquine (HCQ) is a known disease-modifying antirheumatic drug for rheumatoid arthritis. It is also being used in viral arthritis on many occasions. HCQ is also being used to treat coronavirus disease 2019, but the results are not satisfactory. HCQ has been shown to have antiviral effects. In this context, we have a hypothesis that HCQ may be used as a treatment option in post-coronavirus disease 2019 arthritis.

Keywords: COVID-19; Arthritis; Hydroxychloroquine; DMARDS; SARS-CoV-2; Post-COVID-19 arthritis

Core Tip: Hydroxychloroquine is a known disease-modifying antirheumatic drug and has antiviral properties. It had previously been used to treat viral arthritis. In this letter, using future research questions in the context of the evidence in the literature we debate whether hydroxychloroquine can be used in post-coronavirus disease 2019 arthritis.