Freire de Melo F, Martins Oliveira Diniz L, Nélio Januário J, Fernando Gonçalves Ferreira J, Dórea RSDM, de Brito BB, Marques HS, Lemos FFB, Silva Luz M, Rocha Pinheiro SL, de Magalhães Queiroz DM. Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil. World J Exp Med 2022; 12(5): 100-103 [PMID: 36196438 DOI: 10.5493/wjem.v12.i5.100]
Corresponding Author of This Article
Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58-Candeias, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Exp Med. Sep 20, 2022; 12(5): 100-103 Published online Sep 20, 2022. doi: 10.5493/wjem.v12.i5.100
Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil
Fabrício Freire de Melo, Lilian Martins Oliveira Diniz, José Nélio Januário, João Fernando Gonçalves Ferreira, Rafael Santos Dantas Miranda Dórea, Breno Bittencourt de Brito, Hanna Santos Marques, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Dulciene Maria de Magalhães Queiroz
Fabrício Freire de Melo, Breno Bittencourt de Brito, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Samuel Luca Rocha Pinheiro, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Lilian Martins Oliveira Diniz, Departamento de Pediatria, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
José Nélio Januário, Núcleo de Ações e Pesquisa em Apoio Diagnóstico, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
João Fernando Gonçalves Ferreira, Laboratory of Research in Bacteriology, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
Rafael Santos Dantas Miranda Dórea, Dulciene Maria de Magalhães Queiroz, Laboratory of Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
Hanna Santos Marques, Campus Vitória da Conquista, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista 45029-094, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, manuscript drafting, critical revision, and editing, and approval of the final version.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58-Candeias, Vitória da Conquista 45029-094, Bahia, Brazil. freiremeloufba@gmail.com
Received: April 5, 2022 Peer-review started: April 5, 2022 First decision: June 16, 2022 Revised: June 27, 2022 Accepted: August 12, 2022 Article in press: August 12, 2022 Published online: September 20, 2022 Processing time: 162 Days and 7.3 Hours
Abstract
Qualitative antibody tests are an easy, point-of-care diagnostic method that is useful in diagnosing coronavirus disease 2019, especially in situations where reverse transcription-polymerase chain reaction is negative. However, some factors are able to affect its sensitivity and accuracy, which may contribute to these tests not being used as a first-line diagnostic tool.
Core Tip: In this study we compared a quantitative enzyme-linked immunosorbent assay test that detects antibodies against the severe acute respiratory syndrome coronavirus 2 S1 epitope with the qualitative test. Our results demonstrate that the quantitative tests have significantly higher sensitivity rates, evidencing limitations in the use of the qualitative antibody detection test as a first-line diagnostic tool.
