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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Dec 20, 2025; 15(4): 110904
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.110904
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.110904
Short-term blood pressure variability as an indicator of the adaptive capacity of patients with chronic heart failure
Natalia S Akimova, Larisa E Konshina, Yury G Shvarts, Department of Faculty Therapy, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast’, Russia
Anastasiya E Runnova, Maksim O Zhuravlev, Laboratory of Open Biosystems and Artificial Intelligence, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast’, Russia
Anastasiya E Runnova, Maksim O Zhuravlev, Anton R Kiselev, Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Moskva, Russia
Tatyana M Bogdanova, Department of Propaedeutics of Internal Medicine, V.I. Razumovsky Saratov State Medical University, Saratov 410012, Saratovskaya Oblast’, Russia
Co-corresponding authors: Larisa E Konshina and Anton R Kiselev.
Author contributions: Akimova NS, Konshina LE, Runnova AE contributed to concept and design of research, collection and processing of material, text writing; Akimova NS, Konshina LE, Zhuravlev MO, Bogdanova TM contributed to collection and processing of material; Akimova NS, Konshina LE contributed to text writing; Shvarts YG, Kiselev AR contributed to statistical processing of the material; Akimova NS, Shvarts YG, Kiselev AR contributed to scientific editing; all authors have read and approve the final manuscript.
Supported by Ministry of Health of the Russian Federation titled Development of a Hardware-Software Complex for the Non-Invasive Monitoring and Prediction of Circulatory Decompensation in Patients with Chronic Heart Failure, No. 125030703255-7.
Institutional review board statement: The study was reviewed and approved by the local Ethics Committee at the Federal State Budgetary Educational Institution of Higher Education "Saratov State Medical University named after V. I. Razumovsky" of the Ministry of Health of the Russian Federation, Protocol No. 12 dated April 01, 2025, and complied with the requirements of the Helsinki Declaration of 1964 and its revised version of 2024.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anton R Kiselev, Head, Professor, Coordinating Center for Fundamental Research, National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per., 10, str. 3, Moscow 101990, Moskva, Russia. antonkis@list.ru
Received: June 18, 2025
Revised: July 15, 2025
Accepted: October 22, 2025
Published online: December 20, 2025
Processing time: 184 Days and 11.8 Hours
Revised: July 15, 2025
Accepted: October 22, 2025
Published online: December 20, 2025
Processing time: 184 Days and 11.8 Hours
Core Tip
Core Tip: Analysis of hemodynamics was conducted during six-minute walk test (6MWT) of patients with chronic heart failure (CHF). In patients who were taking beta-blockers, assessment of the compensatory reserve using routine methods was not significantly correlated with the severity of CHF. It was found that the assessment of short-term systolic blood pressure variability (BPV), measured immediately after 6MWT and 20 minutes after its completion, can characterize the compensatory reserve in CHF, regardless of whether they are taking beta blockers. Monitoring BPV during routine 6MWT might help doctors personalize recommendations for patients with CHF who are taking beta blockers.