High-density lipoprotein-cholesterol and triglyceride levels and their prognosis in critically ill septic patients

Table 1 Association between clinical and laboratory variables and 28-day mortality

Variables	Non-survivors (n = 31), mean (SD) or median (IQR) or proportion	Survivors (n = 44), mean (SD) or median (IQR) or proportion	P value
Age	67 (14.3)	67 (15.8)	0.47
SAPS III score	77.2 (13.6)	72.7 (12.6)	0.15
SOFA score at sepsis diagnosis	9 (7-11)	7 (5-9)	< 0.01
SOFA improvement at day 3	14/31	37/44	< 0.01
Sepsis foci			0.22
Abdominal	14/31	14/44
Pulmonary	13/31	24/44
Primary bloodstream infection	3/31	1/44
Urinary	0/31	2/44
Comorbidities
Neoplasy	5/31	8/44	0.82
Cirrhosis	4/31	2/44	0.19
COPD	4/31	7/44	0.72
Diabetes	6/31	15/44	0.16
Hypertension	11/31	17/44	0.78
Inflammatory variables at sepsis diagnosis
IL-1 (pg/mL)	116 (34.2-658)	24.4 (16-374)	0.03
IL-10 (pg/mL)	200 (192-389)	177 (127-239)	0.05
IL-6 (pg/mL)	123 (27.9-213)	57.8 (30.6-191)	0.62
IL-1 ratio (pg/mL)	1.05 (0.68-1.62)	0.82 (0.42-1.27)	0.24
IL-10 ratio (pg/mL)	1 (0.91-1.72)	0.99 (0.76-1.4)	0.38
IL-6 ratio (pg/mL)	0.59 (0.26-2.38)	0.96 (0.34-1.71)	0.74
CRP	186 (112-272)	162 (82-215)	0.14
CRP ratio1	0.61 (0.42-0.82)	0.59 (0.39-0.82)	0.87
New-onset HD	16/31	6/44	0.01
Mechanical ventilation	29/31	33/44	0.04
Reinfection during hospital stay	15/31	21/44	0.96

¹CRP ratio: Ratio of C-reactive protein (CRP) levels on day 3 to CRP levels on day 1.

COPD: Chronic obstructive pulmonary disease; CRP: C-reactive protein; HD: Hemodialysis; IL: Interleukin; SAPS: Simplified acute physiology score; SOFA: Sequential organ failure assessment.