Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Crit Care Med. Jun 9, 2026; 15(2): 117211
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.117211
Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.117211
High-density lipoprotein-cholesterol and triglyceride levels and their prognosis in critically ill septic patients
Wagner Nedel, Lílian R Henrique, João Alberto S Deuschle, Luiz H de Oliveira, Laura V de Lima, Giovana T Jahnke, Department of Intensive Care Unit, Conceição Hospital Group, Porto Alegre 91350200, Brazil
Luis V Portela, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035003, Brazil
Author contributions: Nedel W, Henrique LR, Portela LV, de Lima LV, Jahnke GT; manuscript conceptualization; Nedel W, Henrique LR, de Lima LV, Deuschle JAS, de Oliveira LH; manuscript writing and data analysis; Nedel W, Portela LV, Henrique LR, Lima LSV; data collection.
Institutional review board statement: This study was approved by the local Ethics Committee (Plataforma Brazil No. 66240017.0.0000.5530).
Informed consent statement: Written informed consent was obtained from the patient or their next of kin.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
STROBE statement: The authors have read the STROBE Statement—checklist of items—and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The data used in the preparation of this manuscript may be shared, subject to reasonable use, by contacting the corresponding author.
Corresponding author: Wagner Nedel, MD, PhD, Assistant Professor, Department of Intensive Care Unit, Conceição Hospital Group, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Received: December 2, 2025
Revised: January 16, 2026
Accepted: February 4, 2026
Published online: June 9, 2026
Processing time: 171 Days and 5.1 Hours
Revised: January 16, 2026
Accepted: February 4, 2026
Published online: June 9, 2026
Processing time: 171 Days and 5.1 Hours
Core Tip
Core Tip: High-density lipoprotein (HDL) and triglyceride (TG) should be considered inflammatory biomarkers in sepsis, yet they exhibit distinct characteristics in the early response to the condition. TG levels correlate with patient severity upon intensive care unit admission, while lower HDL levels at the time of sepsis diagnosis are slightly linked to higher mortality. However, an early improvement in HDL does not correlate with better outcomes. Nonetheless, both biomarkers are associated with levels of significant inflammatory markers in sepsis, such as interleukin-10 and C-reactive protein.