Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome

Table 1 Demographic parameters, mortality scores and duration parameters

Variable		n (%)/mean ± SD	P value1	r	P value2
Age		61.5 ± 14.6	0.594	-0.186	0.071
Gender	Male/female	52/43 (54.73/40.85)	0.464	0.100	0.333
BMI		26.2 ± 5.4	0.107	0.035	0.736
Mortality scores
APACHE		21.7 ± 7.6	0.345	0.252	0.014
SAPS II		57.07 ± 15.19	0.338	0.328	0.001
SOFA		10.93 ± 3.63	0.700	-0.165	0.109
Duration indicators
ETI, yes/no		84/11 (79.80/10.45)	0.407	0.146	0.159
MV		9.21 ± 15.12	0.013	0.280	0.006
LOS		13.63 ± 16.05	0.005	-0.098	0.342

¹χ² test.

²Pearson’s correlation coefficient test.

r: Correlation coefficient; BMI: Body mass index; APACHE II: Acute Physiology and Chronic Health Evaluation II; SAPS II: Simplified Acute Physiology Score II; SOFA: Sequential Organ Failure Assessment; ETI: Endotracheal intubation; MV: Mechanical ventilation; LOS: Length of stay.

Table 2 Correlation of laboratory findings with fatal outcome

Variable	T0, day 0			T1, day 1			T2, day 3			T3, day 7
	P value1	r	P value2	P value1	r	P value2	P value1	r	P value2	P value1	r	P value2
WBC	0.399	-0.070	0.499	0.483	-0.116	0.264	0.195	-0.094	0.367	0.005	0.208	0.044
RBC	0.161	0.117	0.258	0.095	0.628	0.050	0.027	0.062	0.553	0.045	-0.249	0.015
PLT	0.216	0.106	0.309	0.152	0.107	0.301	0.444	0.147	0.155	0.409	-0.270	0.008
NEU	0.458	0.244	0.017	0.626	-0.077	0.459	0.111	0.300	0.003	0.120	0.304	0.003
LYM	0.758	0.150	0.148	0.417	0.112	0.279	0.049	0.280	0.006	0.052	0.121	0.242
pH	0.467	-0.109	0.295	0.123	0.401	0.000	0.122	-0.424	0.000	0.063	-0.451	0.000
pO2	0.575	0.096	0.353	0.380	-0.036	0.739	0.249	-0.335	0.001	0.027	-0.249	0.015
pCO2	0.265	-0.171	0.097	0.365	-0.044	0.671	0.413	-0.179	0.082	0.916	0.232	0.024
HCO3	0.069	0.158	0.127	0.090	-0.251	0.014	0.567	-0.235	0.002	0.150	0.113	0.276
BE	0.013	0.257	0.012	0.144	-0.285	0.005	0.663	0.289	0.004	0.491	0.194	0.060
Lactate	0.541	-0.198	0.055	0.796	0.261	0.011	0.058	0.219	0.033	0.217	-0195	0.059
Albumin	0.556	-0.027	0.798	0.113	0.007	0.943	0.074	-0.236	0.021	0.051	-0.337	0.001
CRP	0.600	-0.006	0.953	0.932	-0.152	0.141	0.291	-0.150	0.146	0.364	0.372	0.000
PCT	0.372	-0.044	0.671	0.400	-0.022	0.831	0.106	-0.145	0.161	0.493	-0.097	0.348
TSH	0.587	-0.069	0.508	0.248	0.111	0.165	0.079	0.095	0.359	0.026	-0.067	0.548
FT3	0.089	0.039	0.706	0.007	-0.102	0.326	0.028	-0.236	0.021	0.198	-0.249	0.015
FT4	0.000	-0.084	0.420	0.000	0.006	0.951	0.021	-0.334	0.001	0.011	-0.331	0.001

¹Mann–Whitney U test.

²Pearson’s correlation coefficient test.

r: Correlation coefficient; WBC: White blood cells; RBC: Red blood cells; PLT: Platelets; NEU: Neutrophils; LYM: Lymphocytes; pCO₂: Partial pressure of carbon dioxide; pO₂: Partial pressure of oxygen; HCO₃: Bicarbonate; BE: Base excess; CRP: C-reactive protein; PCT: Procalcitonin; TSH: Thyroid-stimulating hormone; FT3: Free triiodothyronine; FT4: Free thyroxine.

Table 3 Correlation of the effects of vasoactive agents and inflammatory prognostic scores with fatal outcome

Variable	T0, day 0			T1, day 1			T2, day 3			T3, day 7
	P value1	r	P value2	P value1	r	P value2	P value1	r	P value2	P value1	r	P value2
Effects of vasoactive agents
VDI	0.389	-0.125	0.229	0.074	-0.122	0.229	0.814	-0.128	0.217	0.842	-0.122	0.237
SI	0.206	-0.155	0.134	0.080	-0.197	0.134	0.027	-0.182	0.078	0.000	0.268	0.009
Inflammatory prognostic scores
NLR	0.712	0.264	0.010	0.689	0.259	0.010	0.236	0.281	0.006	0.176	0.337	0.001
PLR	0.351	-0.160	0.120	0.367	-0.193	0.120	0.200	0.214	0.037	0.659	-0.145	0.162
mGPS	0.496	0.060	0.566	0.030	-0.224	0.566	0.128	-0.106	0.306	0.308	-0.108	0.298
PI	0.328	0.220	0.032	0.305	0.286	0.005	0.100	0.239	0.019	0.327	0.283	0.006

¹Mann–Whitney U test and χ² test for modified Glasgow prognostic score.

²Pearson’s correlation coefficient test.

r: Correlation coefficient; VDI: Vasoactive drug-dependent index; SI: Shock index; NLR: Neutrophil-lymphocyte ratio; PLR: Platelets-lymphocyte ratio; mGPS: Modified Glasgow prognostic score; PI: Prognostic index.