©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Crit Care Med. Mar 9, 2026; 15(1): 115599
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.115599
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.115599
Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome
Mirza Kovacevic, Department of Anesthesiology, Resuscitation and Intensive Care, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina
Mirza Kovacevic, Faculty of Medicine, University of Zenica, Zenica 72000, Bosnia and Herze
Visnja Nesek-Adam, Department of Anesthesiology, Resuscitation and Intensive Care, Clinical Hospital Sveti Duh, Zagreb 10000, Croatia
Visnja Nesek-Adam, Faculty of Medicine, University of Osijek, Osijek 31000, Osjecko-Baranj
Visnja Nesek-Adam, Faculty of Dental Medicine and Health, University of Josip Juraj Stross
Semir Klokic, General Practitioner’s Office, Laufen 4242, Switzerland
Mehmet Yilmaz, Department of Internal Medicine, Kantonsspital Baselland, Liestal 4410, Baselland, Switzerland
Author contributions: Kovacevic M contributed to study conception and design, statistical analysis, manuscript drafting; Nesek-Adam V contributed to patient management; Klokic S contributed to data interpretation, literature review, manuscript editing. Yilmaz M contributed to study supervision, methodology; Kovacevic M and Nesek-Adam V contributed to data collection; Nesek-Adam V and Yilmaz M contributed to critical revision of the manuscript.
Institutional review board statement: The study protocol was reviewed and approved by the Institutional Review Board of the Cantonal Hospital Zenica, Bosnia and Herzegovina (approval No. 00-03-35-38-14/22) on January 31, 2022.
Clinical trial registration statement: This prospective observational study was not registered as a clinical trial.
Informed consent statement: Informed consent was not required for this study because the analysis was performed on anonymized data, which were collected after each patient had provided written consent for participation in the original study.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest relevant to this study.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Data sharing statement:
Due to patient confidentiality, the datasets supporting the conclusions of this study are not publicly available. Anonymized data may be provided by the corresponding author upon reasonable request.
Corresponding author: Mirza Kovacevic, MD, PhD, Assistant Professor, Department of Anes
Received: October 22, 2025
Revised: November 7, 2025
Accepted: January 4, 2026
Published online: March 9, 2026
Processing time: 129 Days and 19.5 Hours
Revised: November 7, 2025
Accepted: January 4, 2026
Published online: March 9, 2026
Processing time: 129 Days and 19.5 Hours
Core Tip
Core Tip: This prospective observational study identifies clinical and laboratory determinants of fatal outcome in septic shock patients with euthyroid sick syndrome. Recognizing these predictors may help clinicians improve risk stratification and optimize management strategies in critically ill patients.