Continuous renal replacement therapy in acute liver failure

doi:10.5492/wjccm.v15.i1.110552

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Mar 9, 2026 (publication date) through Mar 6, 2026

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Crit Care Med. Mar 9, 2026; 15(1): 110552
Published online Mar 9, 2026. doi: 10.5492/wjccm.v15.i1.110552

Table 1 Causes of acute liver failure

Aetiology	Examples
Metabolic	Wilsons disease, fatty liver disease of pregnancy
Viral	HAV, HBV, HDV, HEV, HSV, EBV, CMV
Drugs	Paracetamol, aspirin, niacin, MDMA
Toxins	Amanita mushroom, yellow phosphorous
Vascular	Budd-Chiari syndrome

HAV: Hepatitis A virus; HBV: Hepatitis B virus; HDV: Hepatitis D virus; HEV: Hepatitis E virus; HSV: Herpes simplex virus; EBV: Epstein-Barr virus; CMV: Cytomegalovirus; MDMA: 3,4-methylenedioxymethamphetamine.

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Table 2 Beneficial effects of continuous renal replacement therapy

Metabolic	Toxin	Fluid
Correction of electrolyte imbalance	Ammonia removal	Maintenance of euvolemia
Maintenance of normothermia	Potential removal of additional inflammatory mediators	-
Control of acid-base balance	-	-
Prevention of hyponatremia	-	-

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Citation: Fisher C, Warrillow S. Continuous renal replacement therapy in acute liver failure. World J Crit Care Med 2026; 15(1): 110552
URL: https://www.wjgnet.com/2220-3141/full/v15/i1/110552.htm
DOI: https://dx.doi.org/10.5492/wjccm.v15.i1.110552