Prospective Study
Copyright ©The Author(s) 2024.
World J Crit Care Med. Sep 9, 2024; 13(3): 96132
Published online Sep 9, 2024. doi: 10.5492/wjccm.v13.i3.96132
Table 1 Demographic parameters, mortality scores, mechanical ventilation and outcome
Parameters
Group
P value
Low T3
Low T3T4
Age in years64.8 ± 9.762.1 ± 15.90.483
SexMale12 (50)10 (43.5)0.765
Female12 (50)13 (56.5)
BMI25.8 ± 5.426.6 ± 5.40.712
APACHE II18.8 ± 6.920.8 ± 7.70.398
SAPS II52.5 ± 13.159.0 ± 15.50.046
SOFA10.6 ± 2.810.6 ± 4.60.857
Outcome
Discharge16 (66.6)11 (47.8)0.125
Death8 (33.3)12 (52.1)
ICU stay in days13.6 ± 25.022.0 ± 21.00.837
MV in days9.5 ± 3.115.4 ± 19.30.906
Table 2 Vasopressor requirement and complications according to the groups
Parameters
Group
P value
Low T3
Low T3T4
Vasopressors, No/Yes (%)
Norepinephrine0/24 (0.0/100.0)0/23 (0.0/100.0)Constant
Vasopressin9/15 (37.2/62.5)12/11 (54.2/45.8)0.311
Dobutamine14/10 (58.3/41.7)4/19 (17.4/82.6)0.003
Epinephrine18/6 (75.0/25.0)4/19 (17.4/82.6)0.000
Complications, No/Yes (%)
Pneumonia19/5 (79.2/20.8)16/7 (69.6/30.4)0.450
ARDS16/8 (66.7/33.3)15/8 (65.2/34.8)0.916
Renal failure20/4 (83.3/16.7)7/16 (30.4/69.6)0.000
Liver failure18/6 (75.0/25.0)20/3 (87.0/13.0)0.297
MOF19/5 (79.2/20.8)6/17 (26.1/73.9)0.000
Table 3 Blood count, thyroid hormones and albumin values according to the groups
Parameter
Time
Group
P value
Low T3
Low T3T4
95%CI
Leukocytes as × 109/L, medianT015.6611.210.15 to 0.160.200
T110.5113.340.81 to 0.830.220
T210.1513.540.61 to 0.630.082
Erythrocytes as × 109/L, medianT04.214.010.46 to 0.480.231
T13.963.810.61 to 0.630.216
T23.782.850.53 to 0.510.335
Platelets as × 109/L, medianT0227.00147.000.08 to 0.100.206
T1209.00142.000.24 to 0.260.180
T2180.00180.500.36 to 0.380.160
TSH in mIU/L, medianT01.300.880.24 to 0.250.246
T11.010.780.73 to 0.750.755
T21.181.000.40 to 0.420.417
FT3 in pmol/L, medianT03.993.520.20 to 0.220.206
T14.644.720.92 to 0.930.929
T26.354.750.34 to 0.360.354
FT4 in pmol/L), medianT017.309.200.00 to 0.000.000
T117.3510.700.02 to 0.030.035
T215.1511.400.05 to 0.060.064
Albumin in g/L, mean ± SDT027.29 ± 4.5727.74 ± 4.64-4.17 to 1.580.372
T128.46 ± 3.2927.39 ± 3.88-4.40 to 0.150.131
T229.75 ± 2.9128.17 ± 6.41-3.89 to -0.230.047
Table 4 Inflammatory parameters and blood gas analyzes
Parameter
Time
Group
P value
Low T3
Low T3T4
95%CI
Median
Neutrophils 1T0.880.860.29-0.310.300
T10.880.850.19-0.210.391
T20.860.820.03-0.040.038
Lymphocytes 1T00.050.050.45-0.470.464
T10.060.070.17-0.190.182
T20.010.090.01-0.020.013
CRP in mg/dLT089.00106.000.92-0.930.923
T1145.50153.000.54-0.560.559
T2119.0077.600.08-0.090.436
PCT in ng/mLT03.855.880.44-0.460.452
T17.554.270.29-0.310.310
T22.475.500.50-0.520.492
pHT07.357.330.44-0.460.459
T17.317.390.28-0.290.287
T27.357.460.14-0.150.149
pCO2 in kPaT05.525.060.18-0.190.198
T15.195.590.30-0.320.318
T25.825.100.85-0.860.864
pO2 in kPaT011.7312.100.44-0.460.448
T110.3913.590.82-0.840.829
T29.5912.100.92-0.930.929
HCO3 in mmol/LT021.4521.000.43-0.450.439
T120.7023.250.65-0.670.663
T222.7023.700.41-0.430.413
Lactate in mmol/LT03.702.500.40-0.410.409
T12.501.850.14-0.160.146
T22.002.550.01-0.020.013
Table 5 Vasoactive drug-dependent index, shock index and inflammatory prognostic scores
Parameter
Time
Group
P value
Low T3
Low T3T4
95%CI
VDI T00.110.130.65-0.670.655
T10.030.060.41-0.430.419
T20.000.000.93-0.940.934
SI T01.210.000.31-0.330.322
T10.750.869.14-0.150.148
T20.700.790.32-0.340.329
NLR T015.0012.000.29-0.310.298
T115.0013.000.21-0.230.218
T212.007.000.03-0.040.037
PLR T030.5521.090.26-0.280.550
T130.2620.200.17-0.180.483
T223.4020.000.50-0.520.496
PI T042.5260.780.20-0.220.206
T169.1455.710.21-0.230.225
T282.1029.980.05-0.060.129