©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Nov 30, 2018; 7(6): 73-83
Published online Nov 30, 2018. doi: 10.5492/wjccm.v7.i6.73
Published online Nov 30, 2018. doi: 10.5492/wjccm.v7.i6.73
Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases
Sumit Kapoor, Department of Critical Care Medicine, Montefiore Medical Center, Bronx, NY 10467, United States
Christopher K Morgan, Muhammad Asim Siddique, Kalpalatha K Guntupalli, Department of Pulmonary, Critical Care and Sleep, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Kapoor S, Morgan CK designed the study, collected data and participated in writing and revising the manuscript; Siddique MA collected data, did data analysis and reviewed the manuscript; Guntupalli KK reviewed and revised the manuscript.
Institutional review board statement: This study was approved by the Institutional review board of Baylor College of Medicine with IRB No. H-41092.
Informed consent statement: Requirement for written, informed consent was waived off as it is a retrospective chart review based study.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Corresponding author to: Sumit Kapoor, MD, FCCP, Assistant Professor, Department of Critical Care Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, United States. drkapoorsumit@gmail.com
Telephone: +1-714-3303466
Received: August 6, 2018
Peer-review started: August 7, 2018
First decision: October 8, 2018
Revised: October 21, 2018
Accepted: November 7, 2018
Article in press: November 7, 2018
Published online: November 30, 2018
Processing time: 130 Days and 13.2 Hours
Peer-review started: August 7, 2018
First decision: October 8, 2018
Revised: October 21, 2018
Accepted: November 7, 2018
Article in press: November 7, 2018
Published online: November 30, 2018
Processing time: 130 Days and 13.2 Hours
Core Tip
Core tip: Hemophagocytic lymphohistiocytosis is a serious disorder in intensive care unit (ICU) with high morbidity and mortality. Septic shock, acute kidney injury and respiratory failure are the most common manifestations in ICU. We observed high incidence of bleeding complications and bloodstream infections. High index of suspicion is necessary for ICU patients with severe septic shock and multi organ failure who do not respond to standard treatment.