©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Feb 4, 2016; 5(1): 89-95
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.89
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.89
Corticosteroids for severe influenza pneumonia: A critical appraisal
Wagner Luis Nedel, Intensive Care Unit, Hospital Nossa Senhora da Conceição, Porto Alegre, RS 91350-200, Brazil
David Garcia Nora, Intensive Care Unit, Vila Franca de Xira Hospital, 2600-009 Vila Franca de Xira, Portugal
Jorge Ibrain Figueira Salluh, D’or Institute for Research and Education, Rio de Janeiro, RJ 22281-100, Brazil
Thiago Lisboa, Critical Care Department, Hospital de Clinicas de Porto Alegre, Post-Graduation Program (PPG) Pneumology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-903, Brazil
Pedro Póvoa, Polyvalent Intensive Care Unit, São Francisco Xavier Hospital, Centro Hospitalar de Lisboa Ocidental, 1169-056 Lisbon, Portugal
Pedro Póvoa, Nova Medical School, CEDOC, New University of Lisbon, 1169-056 Lisbon, Portugal
Author contributions: All authors reviewed, edited and approved the final manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Correspondence to: Jorge Ibrain Figueira Salluh, MD, PhD, D’or Institute for Research and Education, Rua Diniz Cordeiro, 30-3o andar, Botafogo, Rio de Janeiro 22281-100, Brazil. jorgesalluh@gmail.com
Telephone: +55-21-25383541
Received: September 28, 2015
Peer-review started: October 2, 2015
First decision: October 27, 2015
Revised: November 30, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: February 4, 2016
Processing time: 116 Days and 16.9 Hours
Peer-review started: October 2, 2015
First decision: October 27, 2015
Revised: November 30, 2015
Accepted: January 8, 2016
Article in press: January 11, 2016
Published online: February 4, 2016
Processing time: 116 Days and 16.9 Hours
Core Tip
Core tip: This review article presents a critical appraisal to the use of corticosteroids in severe influenza infections covering the most relevant clinical studies, underlying mechanisms (pathophysiologic and pharmacologic aspects) and providing a scenario to help clinicians at bedside facing this challenging situation.