©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Feb 4, 2016; 5(1): 74-82
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.74
Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.74
Preemptive mechanical ventilation can block progressive acute lung injury
Benjamin Sadowitz, the Southeastern Center for Digestive Disorders and Pancreatic Cancer, Advanced Minimally Invasive and Robotic Surgery, Florida Hospital Tampa, Tampa, FL 33613, United States
Sumeet Jain, Michaela Kollisch-Singule, Joshua Satalin, Gary Nieman, Department of Surgery, Upstate Medical University, Syracuse, NY 13210, United States
Penny Andrews, Nader Habashi, Critical Care Medicine, Surgical Critical Care, Trauma Critical Care Medicine, The R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, United States
Louis A Gatto, Biological Sciences Department, SUNY Cortland, Cortland, NY 13045, United States
Author contributions: Sadowitz B contributed to acquisition of data, data interpretation and analysis, drafting the manuscript; Jain S, Kollisch-Singule M, Satalin J, Andrews P, Habashi N, Gatto LA and Nieman G contributed to data interpretation and analysis, critical revision of the manuscript.
Conflict-of-interest statement: We have no conflict of interests to disclose.
Correspondence to: Joshua Satalin, Lab Manager (Cardiopulmonary Critical Care Lab), Department of Surgery, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, United States. satalinj@upstate.edu
Telephone: +1-315-4641696
Received: June 10, 2015
Peer-review started: June 11, 2015
First decision: August 16, 2015
Revised: October 15, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: February 4, 2016
Processing time: 226 Days and 20 Hours
Peer-review started: June 11, 2015
First decision: August 16, 2015
Revised: October 15, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: February 4, 2016
Processing time: 226 Days and 20 Hours
Core Tip
Core tip: Mortality from acute respiratory distress syndrome (ARDS) remains unacceptably high. Treating fulminant ARDS, however, is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventive measures. Indeed, since ARDS is a progressive disease, treating this disease in its subclinical phases may prevent the disease from ever occurring. In this regard, early protective mechanical ventilation with airway pressure release ventilation appears to offer substantial benefit and may be the prophylactic treatment of choice for preventing ARDS.